ID   G3PVZ3_GASAC            Unreviewed;       518 AA.
AC   G3PVZ3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=PA domain-containing protein {ECO:0000259|Pfam:PF02225};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021782.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000021782.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000021782.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004366}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004366}; Lumenal side
CC       {ECO:0000256|ARBA:ARBA00004366}.
CC   -!- SIMILARITY: Belongs to the peptidase A22B family.
CC       {ECO:0000256|ARBA:ARBA00006859}.
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DR   AlphaFoldDB; G3PVZ3; -.
DR   MEROPS; A22.007; -.
DR   Ensembl; ENSGACT00000021823.1; ENSGACP00000021782.1; ENSGACG00000016494.1.
DR   eggNOG; KOG2442; Eukaryota.
DR   GeneTree; ENSGT00940000157722; -.
DR   InParanoid; G3PVZ3; -.
DR   OMA; QWGPCHF; -.
DR   TreeFam; TF319186; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000016494; Expressed in spleen and 13 other cell types or tissues.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR   GO; GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:InterPro.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR006639; Preselin/SPP.
DR   PANTHER; PTHR12174; SIGNAL PEPTIDE PEPTIDASE; 1.
DR   PANTHER; PTHR12174:SF34; SIGNAL PEPTIDE PEPTIDASE-LIKE 2A; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04258; Peptidase_A22B; 1.
DR   SMART; SM00730; PSN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..518
FT                   /note="PA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003450102"
FT   TRANSMEM        168..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        240..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..324
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        415..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        477..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          57..140
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
SQ   SEQUENCE   518 AA;  56839 MW;  0E63419ACE176FD7 CRC64;
     MERAVRFIIL SVVFFVSQIN CQEAILHISN ENTNKEYCIV YNQSWTPLSQ TLDDALQYPV
     VNMTSTVLCN PSGVTPDVVK GKALVVMRGD CDFSKKALVA QGLGATALLI ASKIPLITPS
     ANATEYAKIN IPLALMRYKD FIEAQQVFGE GMQVKLYAPP NPKIDASIVV MLLIAIITVS
     LGGFWSGACE RERMNGDGGG GESKADPKEL FLYSPLKVVI FVAMMCGMLV LMYFFYNVMV
     YAIIAIFCLA SASALFSCID AVMEKLSCPT GSFTIKNCTF SVRSLILAAV CISVAVVWGV
     YRNEDRWIWI LQDFLGVAFC LNFLKTVSLS NFKICVILLS LLLVYDVFFV FITPFFTKNG
     VSIMVQVALG PDASGEKTHG NMVEVPAEPQ APSEKLPVVM RVPRFSAWAQ NLCGMQFSIL
     GYGDIIIPGL MVAYCSRFDV WVNSSKKIYF ISCCIAYLLG MIVTFAVMLL SGMGQPALLY
     LVPFTLTASA VVAACRGEMR QFWAGTTYML EVLGKPNS
//