ID G3Q034_GASAC Unreviewed; 727 AA.
AC G3Q034;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Phosphofructokinase, platelet b {ECO:0000313|Ensembl:ENSGACP00000023224.1};
GN Name=PFKP {ECO:0000313|Ensembl:ENSGACP00000023224.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000023224.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000023224.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000023224.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC ChEBI:CHEBI:456216; EC=2.7.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000432};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004679}.
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DR AlphaFoldDB; G3Q034; -.
DR Ensembl; ENSGACT00000023269.1; ENSGACP00000023224.1; ENSGACG00000017568.1.
DR GeneTree; ENSGT00940000155002; -.
DR UniPathway; UPA00109; UER00182.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017568; Expressed in diencephalon and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.450; -; 2.
DR Gene3D; 3.40.50.460; Phosphofructokinase domain; 2.
DR InterPro; IPR009161; 6-Pfructokinase_euk.
DR InterPro; IPR022953; ATP_PFK.
DR InterPro; IPR015912; Phosphofructokinase_CS.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR InterPro; IPR035966; PKF_sf.
DR NCBIfam; TIGR02478; 6PF1K_euk; 1.
DR PANTHER; PTHR13697:SF53; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE; 1.
DR PANTHER; PTHR13697; PHOSPHOFRUCTOKINASE; 1.
DR Pfam; PF00365; PFK; 2.
DR PIRSF; PIRSF000533; ATP_PFK_euk; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Phosphofructokinase; 2.
DR PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..271
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT DOMAIN 355..640
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
SQ SEQUENCE 727 AA; 79732 MW; 494D4AC76C99EF7A CRC64;
QGYQGMVDGG DNIKEATWES VSSMLQVGGT VIGSARCKEF RVREGRLRAA RNLVQRGINN
LCVIGGDGSL TGANLFREEW SGLLDELLGQ GLIDEEAARS NSELHIVGMV GSIDNDFCGT
DMTIGTDSAL HRIIEVVDAI MTTAQSHQRT FVLEVMGRHC GYLAMVSALA CGADWVFIPE
MPPGDGWEDV MCQKLSENRA DKKRLNIIIV AEGAIDSHNK AITPDYIKEL VVRCLGFDTR
VTILGHVQRG GTPSAFDRIL ASRMGVEAVL ALLEASATTP ACVVSLVGNQ AVRLPLMECV
QTQEVQKAMD EKKFEEAVRL RGSSFENNLT TYRLLSYRKA DSELPNVSAT RSSFNVAVLN
VGAPAAGMNA AVRAAVRVGI TEGHKMFAVS DGFEGFYKGQ IKEIKWGDVG GWTGQGGSLL
GTKRTLPGKH LEEIAEQIRI HNINALMVIG GFEAYVGLLE LAAARDRYDE LCVPMVMVPA
TVSNNIPGSD LSIGSDTALN AITDTCDRIK QSASGTKRRV FIIETMGGYC GYLATVGGLA
AGADTVYIYE EPFDIRDLQA NVEHLTQKMK TSIQRGLVLR NENSNENFTT DFIYQLYTEE
GRGVFDCRKN ILGHMQQGGA PSPFDRNFGT KVAAKAIQWV TKTLKESYKG GRVFTNSEDT
ACLLGMRRRA LVFQPVSKLR DETDFVHRIP KEQWWLKLRP LMKILAKYKT SYDVSDSGQL
EHVTRVR
//
