ID   G3Q2F0_GASAC            Unreviewed;      1328 AA.
AC   G3Q2F0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Regulatory associated protein of MTOR, complex 1 {ECO:0000313|Ensembl:ENSGACP00000024049.1};
GN   Name=RPTOR {ECO:0000313|Ensembl:ENSGACP00000024049.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000024049.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000024049.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000024049.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC       {ECO:0000256|ARBA:ARBA00009257}.
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DR   STRING; 69293.ENSGACP00000024049; -.
DR   Ensembl; ENSGACT00000024096.1; ENSGACP00000024049.1; ENSGACG00000018193.1.
DR   eggNOG; KOG1517; Eukaryota.
DR   GeneTree; ENSGT00640000091541; -.
DR   InParanoid; G3Q2F0; -.
DR   OMA; HHHPLWK; -.
DR   TreeFam; TF105729; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000018193; Expressed in head kidney and 13 other cell types or tissues.
DR   GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR004083; Raptor.
DR   InterPro; IPR029347; Raptor_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR   PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR   Pfam; PF02985; HEAT; 2.
DR   Pfam; PF14538; Raptor_N; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PRINTS; PR01547; YEAST176DUF.
DR   SMART; SM01302; Raptor_N; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          49..202
FT                   /note="Raptor N-terminal CASPase-like"
FT                   /evidence="ECO:0000259|SMART:SM01302"
FT   REGION          746..766
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          849..920
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        750..766
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        849..888
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1328 AA;  148673 MW;  0444C13C1EF66758 CRC64;
     IHSPAVGLAE EEEADMNDWK LPLAFMKKRH CEKIEGSKAL AQSWRMKDRM KTVSVALVLC
     LNVGVDPPDV VKTSPCARLE CWIDPLSMSP QKALETIGAN LQKQYENWQP RARYKQSLDP
     TVDEVKKLCT SLRRNAKEER VLFHYNGHGV PRPTVNGEIW VFNKNYTQYI PLSIYDLQTW
     MGSPSIFVYD CSNAGIIVKS FKQFALQREQ ELEVAAINPG HPLAQMPLPP SMKNCIQLAA
     CEASELLPMN PDLPADLFTS CLTTPIKIAL RWFCMQKSAR LVPGVTLDLI EKIPGRLNDR
     RTPLGELNWI FTAITDTIAW NVLPRDLFQK LFRQDLLVAS LFRNFLLAER IMRSYNCTPV
     SSPRLPPTYM HAMWQAWDLA VDICLSQLPT IIEEGTAFRH SPFFADQLTA FEVWLTMGVE
     NRNPPEQLPI VLQVLLSQVH RLRALQLLGR FLDLGPWAVS LALSVGIFPY VLKLLQSSAR
     ELRPMLVFIW AKILAVDSSC QADLVKDNGH KYFLSVLADS YMPAEHRTMA VFILAVIVNS
     YNTGQEACLQ GNLIAICLEQ LSDPHPLLRQ WVAICLGRIW QNFDPARWCG VRDSAHEKLY
     TLLSDPIPEV RCAAVFALGT FVGNSAERTD HSTTIDHNVA MMLAQLINDG SPVVRKELVV
     ALSHLVVQYE SNFCTVALQF IEEEKNYTVP SPANTTESGN LTPVRDSPAI PRLRSVNSYT
     NIRAATTARN LNKSLQNLNL NEEGGPAAFS PGNLSTSSSA SSTLGSPDND EYILSFETID
     KMRRVSSYSS LNSLIGVSFN SVYTQIWRVL LHLAADPFPE VSDLAMKVLN SIAYKATMNA
     RPQRILDSGS LTQSAPASPT SKGTHIHQAS GSPPMPSTSS SSLTNEVPKP PTREPPATRP
     PYTPTSGGQA PHSHQFPRTR KMFDKGPEQA AEDGDEPGGH RNYICAALQT GLCDWSAKYF
     AQPVMKIPEE HDVESQVRMD RQWRFLRNTR VRKQSRGITQ KGVSRLDDQI FINRNPGVPS
     VVKFHPFNTC IAVADKDSIC FWDWEKGERL DYFYNGNPRY TRITAMEYLN GHDCSLLLTA
     TADDGALRIW KNFADQKNPE MVTAWQGLSD MLPTTRSAGM VVDWEQETGL LMTSGDVRVI
     RIWDTDREMK VQDIPTGADS CVTSLSCDSQ RSLIVAGLGD GSVRVFDRRM GPNECRVMTY
     REHGAWVVKA HLQKETEGHI ISVSVNGDVR FFEPRSPDSI NVLQTVKGLT ALDIHPQANL
     FACGSMNQFI AVYNSNGDVI SNIKYYDGFM GQRIGAISCL AFHPHWPHLA VGSNDYYMSI
     YSAEKRLR
//