ID G3Q4M0_GASAC Unreviewed; 1577 AA.
AC G3Q4M0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Collagen IV NC1 domain-containing protein {ECO:0000259|PROSITE:PS51403};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000024824.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000024824.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000024824.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR STRING; 69293.ENSGACP00000024824; -.
DR Ensembl; ENSGACT00000024873.1; ENSGACP00000024824.1; ENSGACG00000018779.1.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00940000153991; -.
DR InParanoid; G3Q4M0; -.
DR OMA; GDQGQTF; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018779; Expressed in zone of skin and 6 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN ALPHA-1(X) CHAIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 7.
DR SMART; SM00111; C4; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1577
FT /note="Collagen IV NC1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450552"
FT DOMAIN 1439..1577
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 43..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..429
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..832
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1577 AA; 154263 MW; 16517DE4EEB89A4C CRC64;
AFYQRCPHLL FCVCFSPPLQ GTLDEPCAGR NCGQGCRCNP EKGSRGRPGS LGELGQSGPA
GPKGEKGHLG LKGPSGPKGD KGPMGVPGFQ GTDGVPGHPG QDGGRGPAGL DGCNGTRGEP
GRPGYGNGEP GSPGFAGPSG PKGQKGEPQY IPGDLTNLPG VQGRDGPPGI RGPSGRPGSP
GVRGPEGFSG RPGPPGPPGL MGSQSNGYEG EKGDKSDTCR AAGLSTWPAG QRNSFLHLSS
KESDSKGASP RALPAGEHDS CVRRLRTCAA SGLRQSELEP PSHMDQGTSS SPLPLVPTSS
CLSGAQSTPG FSGSPGYNGV KGDQGDPGAP GPPAYVTDRG TSIQGQTGDP GLNGAPGFPG
DRGFPGFKGQ PGVPGVGGVG SGRPGPPGYP GTSGPKGETG DPSPTAYGPE GRPGIPGAPG
APGPRGPPGP STARRHEIKH LKRCDRAPRC GFLALTAVCG GCGGKCGGEE AVPPPPGCFS
PLWPQGCALL FTGFTMASMH GKERGSAKRG LAQTSGLTDS LNQLKPGQEL APPSSTLAAC
LPHEGPGSSQ QFHVVAGDPR PDFPGEPGPP GSRGAPGERG YNGFRGTLTH TQGAGGGGGA
TMGLTGGSSA XGDPGRDGLP GPPGSPGLKG QVLPCIIDGE AAEPGPPGEP GRPGAKGEPG
FPGNAGRPGF DGSKGERGDP GFGGQPGQQG FPGQRGDPGI PGSPGQSVDG GRGNNGVPGR
PGSKGQPGEV LGATPGGPGQ DGLPGIPGDK GQPGTPGGPG IPGGHPFLGV GSFVIGCQGE
TLSPRFPGRK GERGDPGFPG PAGMKGTLGQ PGFSGSPGPR GPPGPPGPGT RDGFPGSPGR
KGRPQRPLLL TVGLPAPPRC DAPRADCVSL SAGETGAAGL TGFPGLQGRP GGPGFPGAKG
EAAGPGRDGL PGAPGFPGQK AGDRGYPGPP GPPSPFYPQE LVTGEPGTPG RSGLPGFPGP
RGDKGQSGLP GRQGLPGLPG YAELSKGQPG QPGFPGRPGE PGRPGPKGES GIMGFPGMSG
PRGDDGSPGF PGNPGEFGRP GGKGAPGESY GYPGSPGAKG QPGDPGFPGG RGSDGAPGDS
GFPGGPGFPG TKGGPGEGGR PGITGSPGFP GPKGQSGYPG ESGVNGSPGL PGGPGGPGSK
GLPGPPGLDG LNGLAGPKGL PGTRGVNVGG RPGEPGAPGF KGERGITYPG NPGFPGPKGE
RGDSGVPGRP GLVGFPGLPG PSGVTVGSNI PGPSGDPGLP GLDGEYGLMG PPGPPGPPGP
GTAQGDRGDP GLPGFPGSPG RKGDAAIPGG PGLPGSPGFK GGRGDSGYGG NPGVKGYAGD
PGYYGNKGAR GLPGRQGRKG DAGVFIPPID PPSELYGDTG FPGAVGGPGA AGPPGQSGQP
GRAGPKGRPG PVGKLGRTGS PGFPGPIGDA GPPGFLGPTG EQGQQFSLPV CPCQSSSIGY
TLVKHSQSSQ VPMCPQGMAQ LWDGYSLLFV EGQEKAHNQD LGQPGSCLPR FSTIPFLYCS
PNEICYYASR NDKSYWLSTT APIPMMPVAE QQIQPYISRC SVCEAPSLPV AVHSQDMTIP
TCPPGWRSLW IGYSFLM
//
