ID G3Q5E2_GASAC Unreviewed; 661 AA.
AC G3Q5E2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Regulatory factor X, 1b (influences HLA class II expression) {ECO:0000313|Ensembl:ENSGACP00000025098.1};
GN Name=RFX1 {ECO:0000313|Ensembl:ENSGACP00000025098.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000025098.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000025098.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000025098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3Q5E2; -.
DR STRING; 69293.ENSGACP00000025098; -.
DR Ensembl; ENSGACT00000025147.1; ENSGACP00000025098.1; ENSGACG00000018987.1.
DR eggNOG; KOG3712; Eukaryota.
DR GeneTree; ENSGT01050000244879; -.
DR InParanoid; G3Q5E2; -.
DR OMA; LYYHYIL; -.
DR TreeFam; TF321340; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018987; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF23; MHC CLASS II REGULATORY FACTOR RFX1; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 188..263
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 72907 MW; E021CF4CAE9E43C2 CRC64;
LPLASLEGSV HSNDSVSDSS PSAPGVPSQV VQPVQSTQQV CSLLQAEHAY SGQVQYVDGG
GDVTFTTSSI RSSDYPFSDS PIYSQTPPTS SSYYETTPST EADITGSVTS QSVSVATGGA
NCGGGGAGAG GYVIQGGYML GGGAACGGGQ TFSSPNSRAP PATVSTEVPS EQCAVNSQSN
RSTVRLPQVQ WLCDNYEGAE GVSLPRCTLY YHYLLHCQEQ KLEPVNAASF GKLIRSVFMG
LRTRRLGTRG NSKYHYYGLR IKSGSPLLRL MDEQQHMAMR QQPFSQKNRI KPLHKAQGIT
NGSGGLGQQA AALCDISAQV QQYQQFLEPS RPLPDFVDID QQHGTLPDGV LLEHLHSFQA
LYREHCEAIL DVMVNLQFTL VETLWKSFWR FSQSSDTESI NLHNESEKRL PKSCLVVLCK
YEPVLRWTKE CDNLLYQTLV EILISDVLRP IPSALTQAIR NFAKSLENWL TGAMMNIPEE
MVRIKVVCVG SFSQTLRRYT SLNHLAQAAR AVLQNTAQIN QMLSDLNRVD FTNVQEQASW
VCQCEDRVVQ QLEQDFKTTL QQQNSLEQWA TWLDGVVSEA LKPYEHNSAA LPKAAKVFLL
NWSFYSSMVI RDLTLRSAAS FGSFHLIRLL YDEYMYYLIE HRVAQAKGVT PIAVMGEGGD
L
//
