ID   G3Q9R4_GASAC            Unreviewed;       757 AA.
AC   G3Q9R4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   RecName: Full=SIM bHLH transcription factor 2 {ECO:0008006|Google:ProtNLM};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000026630.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000026630.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000026630.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3Q9R4; -.
DR   STRING; 69293.ENSGACP00000026630; -.
DR   Ensembl; ENSGACT00000026682.1; ENSGACP00000026630.1; ENSGACG00000020158.1.
DR   eggNOG; KOG3559; Eukaryota.
DR   GeneTree; ENSGT00940000159985; -.
DR   InParanoid; G3Q9R4; -.
DR   OMA; ETPYSHI; -.
DR   TreeFam; TF317772; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR010578; SIM_C.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF36; SIM BHLH TRANSCRIPTION FACTOR 1B-RELATED; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   Pfam; PF06621; SIM_C; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..53
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          78..141
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          234..289
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          712..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        721..737
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  84353 MW;  B6926B4B5A6055B9 CRC64;
     MKEKCKNAAK TRREKENGEF YELAKMLPLP AAITSQLDKA SIIRLTSSYL KMRTVFPDVG
     LGDGWGRSTR LSPLDSMAKE LGSHLLQTLD GFVFVVASDG KIMYISETAS VHLGLSQVEL
     TGNSIFEYIH PSDHDEMTAV LGLCQPPHHH FSLEYEIERS FFLRMKCVLA KRNAGLTCGG
     YKVIHCSGYL KVRQYMMDMA LYESSYQTVG LVAVGHSLPP SGITEIKLHS NMFMFRASLD
     LKLIFLDTRV AELTGYEPQD LIEKTLYHHV HTCDVFHLRY AHHLLLVKGQ VTTKYYRMLS
     KHGGWVWVQS YATIVHNSRS SRPHCIVSVN YVLTDVECKE LQLSDDQSRA TKPGLSLASV
     QDHRKQLKTK AVKMKTKLRA VHYPETVVPN LKDRLNCSPQ RGLWKERSEY PLTSCSERSS
     SLSPETSRLS CSPTYNLTLH YPYNHRHLDA QNHLPGSGLS PQPAPQIIGS LHSRGSVGWN
     ISCPAAPNKY TGVQFAPPAA HPLSRQSPEL AADRRHPDEI YNDCSSPTNP HSTGSLKEEP
     YEHYTFFHGE LPEVCPHPRP QSAKDIKRLG QQVRHNTRGE GPQGDRGLAC PLIRDLVPGK
     AEQGGSLHGA TGQPLPVQMA LEQRRRLCMM EAPYSHPASA YPQPANSLQQ HGATAELQPR
     CAEQDRRMLI GMGVGVGLPT QNPYVSLKFH KVLGKHGSIK APAFTTLSHV TDGHSYHGKE
     KASYSCNSQS PSSDSSAESH REIPHYIGTS VIITNER
//