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Database: UniProt
Entry: G3QBR1_GASAC
LinkDB: G3QBR1_GASAC
Original site: G3QBR1_GASAC 
ID   G3QBR1_GASAC            Unreviewed;      5031 AA.
AC   G3QBR1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 43.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSGACP00000027327};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000027327, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000027327}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000027327}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGACP00000027327}.
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DR   STRING; 69293.ENSGACP00000027327; -.
DR   Ensembl; ENSGACT00000027379; ENSGACP00000027327; ENSGACG00000020663.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3QBR1; -.
DR   OMA; DIPARRN; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4320   4343       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4547   4567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4636   4657       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4774   4795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4833   4853       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4912   4935       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1350   1560       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   5031 AA;  570894 MW;  AEE56A7BD35C18A7 CRC64;
     MAEGADGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNIPP
     DLAICCFILE QSLSVRALQE MLSNSSVDEA VDLDKWSSQG GGHRTLLYGH AILLKHTHSS
     MYLCCLTTSR SLTDKLAFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYA SGDLMVDASF MQTLWTMTPV MSGCELVEGF LTGGYVLRLF HGHMDECLAI
     PGADQGDDQR RVAHYEGGAV CSHARSLWRL EPLRIAWSGG HIKWGQSFRI RHITTGRYLC
     LDEEKGLLLV DPEKANSKMS AFCFRISKEK IEVIQKRDVE GMGTPEIKYG ESMCFVQHVS
     TGLWLTYAAV DAKSARLGPL KRKAILHKEG HMDDALTVAR SQTEESQASR MIFSTSGLFN
     QFIKGLDALG GKNKSAGSTS LPMDTVVLSL QDLIFYFRPP EEELEHEDKQ FKLRSLKNRQ
     NLFQEEGMIT HVLDCVDRLN VYNTAAHFSE YAGEEAAESW KEIVNLLYDL LASLIRGNRA
     NCALFCDNLD WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR
     NHKVLDVLCS LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIINYVTSMR PNIFLGTCEG
     STQYKKWYFE VMVDEVEPFL TAQPYHLRVG WALTEGYSPY PGGGEGWGGN GVGDDLYSYG
     FDGLHLWSGR VSRHVATPNH HVLAAEDVVS CCLDLSVPSI SFRINGHPVQ GMFENFNLDS
     LFFPVVSFSA GVKLRFLLGG RHGDFKFLPP PGYAPCYEAV LPRDRLRIEP IKEYKHDFEA
     VRNLLGPTQS LSHTAFTPGP VDTIQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTFGP
     FRDDNKKLHP CLVDFQSLPE PEKNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKKTKL
     PKTYMQSSGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDIMN
     KRNPRLVPYN LLDEKTKKTN RDTVFAAVRT LIGYGYNIEP PDQESSGLGP ESGDKIRVFR
     AEKSYAVTQG KWYFEFEAVT VGEMRVGWAR PSVRADTDLG ADEFAYVFNG FKAQRWHVGN
     EPFGRQWLSG DVVGCMIDLT EMNIMFTLNG EMLISDSGSE MAFKDIEIGE GFIPVCSLGL
     SQIGRINLGQ NVSSLRFFTI CGLQEGFEPF AINMKRDITM WFSKSLPQFI NAMDHPHVEV
     SRVDGTVESA PCLKVTHKTF GSQNANTDLL FFRLSMPVEF HETFKVPAGT TLLTRALTIP
     EDEVLEVDPD SDFEILKKSA TRKEQEEEKK EPSVPKEIPA IKNGENEKDA STEKSKKKGF
     LFKAKKAALI NPPPVVPAMP RLVEDVVPDD RDDVDIILNT TTYYYSVRVF AGQEPSGVWV
     GWITPDYHQY DPHFDISKVR NVTVTVGDDK GNIHDSIKRS NCYMVSGGEF GSSQQTRVSQ
     EDFVIGCLID LEAGLMTFTA NGKEINTFYQ VEPNTKLFPA VFVLPSSQNM IQFELGKLKN
     IMPISAAMFR SERKNPVPQC PPRLDVQMLT PVIWSRMPNH FLAPDTGRVS ERLGWVVHCR
     EPLTMMALHI PEESRCIDIL ELSEHMDLLK FHYHTLKLYG LVCALGNNRV AHALCSHVDE
     SQLFYAIEDT YLPGPMRSGF YDLLISMHLE SAKRNRLGTN KEFIVPMTDE TRSITLYSDK
     SHALPGVGLT TCLRPKLHFS SIGFVGTDQD IYTLSPVIPL QVLKTKALNM LTEAVQDGVQ
     AMRDPVGGSV EFHFVPILKL ISTLLIMGVF DDEDVTHILK MLEPTVFSGK QAEEPTEENV
     NVKEQKEQKT TPKEGVMQED QQESIFEDDG LGEDGEEEME GDEKLQTDSI VPHEGKVDET
     DQVNGEKGAE ETEKEIKEEN KEEHLEQGLF QMKLPESVKL QMCTLLQYFC DCELRHRVEA
     ITSFSDQFVS HIQCNQRHRY NELMLAFTMS AAETARKTRE FRSPPQEQVN MLMNFKNCSE
     DDECPVPDEV RDALMTFHNA LLGHCGVHIE EEEQEEEVDN SVRGRLVRLL EKVKRIREKK
     VEVEPEPQED KKPSTLQELI SHTMIHWAQE SFIQNPELVR MMFSLLHRQY DGLGELMRAL
     PKAYTINAVS IHDTMDLLEC LGQIRSLLIV QMGPEEERLM IQSIGNIMSN KVFYQHPNLM
     RALGMHETVM EVMVNVLGGG DSKEIRFPRV VTNCCRFLCY FCRISRQNQR SMFDHLSYLL
     QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEMV VKYLAGCGLQ SCPMLLSKGY
     PDIGWNPCGG EKYLDFLRFA VFVNGESVEE NANVVVRLLI RRPECFGPAL RGEGGNGLLA
     AIEEAIKISE DPARDGPSVK KDRRFPMFGG EEQQEENRVH LGNAIMSFYS ALIDLLGRCA
     PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLSVQIP SFGKDNSIIE PKMSASFVPD
     HKAPMVLFLD RVYGIDNQDF LLHVLEVGFL PDMRAAASLD TVAFGTTEMA LALNRYLCSA
     VLPLITKCAP LFAGSDHRAI MIDSMLHTIY RLSRGRAFTK AQRDIIEECL MALCKHLRPS
     MLQHLLRRLV FDVPILNEYA KMPLKLLTNH YERCWKYYCL PNGWANFGVS SEEELHLTRK
     LFWGIFESLA HKKFDAEIFK ISMPCICAIA GAIPPDYVDA SYSSKTEKKA SVDAEGNFDP
     KPVETTNTII PERLDSFINK YAEYTHDRWA FEKIQNNWSY GEALDENAKT HPMLRPYKTF
     SEKDKEIYRW PIKESVKAMI AWEWNLDKAR EEDESDKKKA VSRKISQTAQ ATYDPSHGYS
     PQPIDISHMA LSRDLQSMAE QLAENYHNTW GRKKKLELQS KGGGTHPLLV PYDTLTAKEK
     ARDREKAHEL LKFLQLNGYA CTRGLKDMES DISSIEKRFA YGFLQKLLKW MEIAQEFIAH
     LEAVVSSGRV EKSPHEQEIK FFAKILMPLI NQYFKNHCLY FLSTPAKVLG SGGLSSNKEK
     EMIASIFCKM SALVRHRVSL FGTDASAIVN CLHILARSLD ARTVMKSGPE IVKAGLRSFF
     ESAADDIEKM VENLKLGKVS KGNQQVKGVS QNINYTTIAL LPVLTSLFDH IAQHQFGDDV
     MLDDLQMSCY RIMCSIYSLG TVKNPHVERQ RPALGECLAH LAAAMPVAYL EPHQNEYNAF
     SVYTTKTPRE RAILGLPNEV QELCPDIPEL DALLKEIGDL AESGARYTEM PHVIEITLPM
     LCNYLPRWWE RGLENFPEME GQICTDVTSE HLNQLLGSIM KIVVNNLGID EASWMKRLAV
     FSQPIVSRAK PEMLKSHFIP TMEKLKKRTS KVVAEEDHLR MEGKSEGDEE DGTIRDEFAV
     LCRDLYALYP LLIRYVDNNR ARWLTCPDPD AEELFRMVGE VFIFWSKSHN FKREEQNFVV
     MNEINNMSFL TADSKSKMSK GGDSEGGGSD TERTKKKRRG DRYSVQTSLI VAALKKMLPI
     GLNMCSPADQ ELINLAKIRY SLRDTDEEVR EFLQHNLHLQ GKVDNPSMRW QMALYKEMAG
     KAEDADAPMK VVKRVQEVSA VLYHLEVTEH PFKSKKMVWH KLLSKQRRRA VVACFRMTPL
     YNIPRHRASN MFLEGYKRNW LHSEGYSFED RMIDDLSKAM EQEEGDEEEE RETKPDPLHQ
     LILHFSRTAL TEKSKLDTDH LYMAYAEIMA KSCHIGEEEE GGEEMVENAE DEMSFEDKEM
     EKQRLLYQQS RLHNRGAAEM VLQMISACKG ETGPMVTTTL KLGISILNGG NNVVQRKMLE
     YLRDKKDVGF FLSVQALMQT CSVLDLNAFE RQNKAEGLGM VSEEGSNEKV MSDDEFTCDL
     FRFLQLLCEG HNNADFQNYL RTQTGSTTTI NIIICTVDYL LRLQESISDF YWYYSGKDII
     DEPGKKNFSK AMTVAKQIFN SLTEYIQGPC TGNQQSLAHS RLWDAIVGFL HVFAHMMMKL
     AQGKKDSSQI GLLKELLDLQ KDMVVMLLSL LEGNVVNGTI ARQMVDMLVE SSSNVEMILK
     FFDMFLKLKD IVASDAFRDY VTDPRGLISK KDFQKAMDSQ KQYSHSEIQF LLSCSEADEN
     DMIHYEEFAN RFQEPAKDIG FNIAVLLTNL SEHVPHDVRL QNFLEQADSV LNYFRPFLGR
     IEIMGASRKI ERIYFEITEV NRKQWEMPQV RESKRQFIFD VVNEGGESEK MEMFVNFCED
     TIFEMNIASQ ICDEDSNGEE GQPESSSAFA DFVNSVLCFF SIFTFRNLRR QYRRVRKMSF
     KEIVVALSTF FWTILMSILH FIYNVCKGFF MIIWQTLFGG GLVEGAKNIT VTEILASMPD
     PTQDDVHGDG PGEPRTEEQD TGGVTDTGET GSGEEEEEDS QEKEGGRVAG VDAPGGLGDM
     GVESTVEPPT PEGTPITKRK VPPEETEASQ KPPEPVEEPP PKPEKADVSV ENAEKESQSK
     EEEKPEERKK SPKKKEKKPK REGGFQIWNE LENQRNKFMN YLSRNFYNLR FLALFLAFAL
     NFILLFYKVS DSPPEGEEME GSGLSEGSGL FEGSGFFEGS GEEAEGSGMN EGDEDEEEVA
     IYFYLEESTG YMQPTLTFVA ALHTVISFIC IIGYNCLKIP LVIFKREKEL ARKLEFDGLF
     ITEQPEDDDI KGQWDRLVLN TPSFPNNYWD KFVKRKVLDK YGDIYGRERI AELLGVDLAS
     LDVSQQHEKK QEEPDTSVFS WTTTIDIKYQ IWKFGVVFTD GTFLYLCWYT IMSLLGHYNN
     FFFACHLLDI AMGVKTLRTI LSSVTHNGKQ LMMTLGLLAV VVYLYTVVAF IFFRKFYNKG
     EEEDEPDMKC DDMMTCYLFH MYVGVRAGGG IGDEIEDPAG DEYELYRVVF DITFFFFVIV
     ILLAIIQGLI IDAFGELRDQ QEQVKEDMET KCFICGIGSD YFDTTPHGFE THTLDEHNLA
     NYMFFLMYLI NKDETEHTGQ ESYVWKMYQE RCWDFYPAGD CFRKQYEDQL S
//
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