UniProt: G3QHP7

Database: UniProt
Entry: G3QHP7_GORGO

LinkDB:  G3QHP7_GORGO 
Original site:  G3QHP7_GORGO

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Ontology (14)   
   GO (14)   
Gene (4)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (10)   
   RefSeq(pep) (10)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (19)   
   InterPro (11)   
   Pfam (3)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (49)   

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ID   G3QHP7_GORGO            Unreviewed;       736 AA.
AC   G3QHP7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=KRIT1 ankyrin repeat containing {ECO:0000313|Ensembl:ENSGGOP00000001880.2};
GN   Name=KRIT1 {ECO:0000313|Ensembl:ENSGGOP00000001880.2};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000001880.2, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000001880.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000001880.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000001880.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; CABD030053577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018886742.1; XM_019031197.1.
DR   RefSeq; XP_018886743.1; XM_019031198.1.
DR   RefSeq; XP_018886744.1; XM_019031199.1.
DR   RefSeq; XP_018886745.1; XM_019031200.1.
DR   RefSeq; XP_018886747.1; XM_019031202.1.
DR   RefSeq; XP_018886748.1; XM_019031203.1.
DR   RefSeq; XP_018886749.1; XM_019031204.1.
DR   RefSeq; XP_018886750.1; XM_019031205.1.
DR   RefSeq; XP_018886751.1; XM_019031206.1.
DR   RefSeq; XP_018886752.1; XM_019031207.1.
DR   AlphaFoldDB; G3QHP7; -.
DR   STRING; 9593.ENSGGOP00000001880; -.
DR   Ensembl; ENSGGOT00000001921.3; ENSGGOP00000001880.2; ENSGGOG00000001906.3.
DR   GeneID; 101127996; -.
DR   CTD; 889; -.
DR   eggNOG; KOG4335; Eukaryota.
DR   GeneTree; ENSGT00530000063721; -.
DR   HOGENOM; CLU_022188_0_0_1; -.
DR   InParanoid; G3QHP7; -.
DR   OMA; MKMLEHC; -.
DR   OrthoDB; 2876335at2759; -.
DR   TreeFam; TF317921; -.
DR   Proteomes; UP000001519; Chromosome 7.
DR   Bgee; ENSGGOG00000001906; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR   GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR   GO; GO:0033622; P:integrin activation; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IBA:GO_Central.
DR   GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR   GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:2000114; P:regulation of establishment of cell polarity; IBA:GO_Central.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13197; FERM_C_CCM1; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.30.70.2240; KRIT, N-terminal Nudix domain, NPxY motif-rich region; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR041791; KRIT1_FERM_C.
DR   InterPro; IPR032022; NUDIX.
DR   InterPro; IPR043058; NUDIX_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR13283; KREV INTERACTION TRAPPED 1-RELATED; 1.
DR   PANTHER; PTHR13283:SF11; KREV INTERACTION TRAPPED PROTEIN 1; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF16705; NUDIX_5; 1.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00295; B41; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   REPEAT          354..377
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          420..734
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
SQ   SEQUENCE   736 AA;  84406 MW;  0AEE2A5F53911157 CRC64;
     MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLEMKLQG
     NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN
     TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP
     SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY
     TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD
     SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH
     FAAGGGHAEI VQILLNHPEI DRHITDQQGR SPLNICEENK QNNWEESAKL LKEAINKPYE
     KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP
     LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL
     KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR
     ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV
     GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK
     LLMKLNGQLM PTERNS
//

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