ID G3QMI4_GORGO Unreviewed; 1005 AA.
AC G3QMI4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Tumor protein p53 binding protein 2 {ECO:0000313|Ensembl:ENSGGOP00000003725.3};
GN Name=TP53BP2 {ECO:0000313|Ensembl:ENSGGOP00000003725.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003725.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003725.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003725.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000003725.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030009136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030009137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QMI4; -.
DR Ensembl; ENSGGOT00000003812.3; ENSGGOP00000003725.3; ENSGGOG00000003787.3.
DR eggNOG; KOG0515; Eukaryota.
DR GeneTree; ENSGT00940000153463; -.
DR TreeFam; TF105545; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000003787; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd11953; SH3_ASPP2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047163; ASPP1/2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24131; APOPTOSIS-STIMULATING OF P53 PROTEIN; 1.
DR PANTHER; PTHR24131:SF8; APOPTOSIS-STIMULATING OF P53 PROTEIN 2; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 835..867
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 868..900
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 934..996
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 199..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 111376 MW; 54C528566AB871D4 CRC64;
MDLTLAELQE MASRQQQQIE AQQQLLATKE QRLKFLKQQD QRQQQQVAEQ EKLKRLKEIA
ENQEAKLKKV RALKGHVEQK RLSNGKLVEE IEQMNNLFQQ KQRELVLAVS KVEELTRQLE
MLKNGRIDGH HDNQSAVAEL DRLYKELQLR NKLNQEQNAK LQQQRECLNK RNSEVAVMDK
RVNELRDRLW KKKAALQQKE NLPVSSDGNL PQQAASAPSR VAAVGPYIQS STMPRMPSRP
ELLVKPALPD GSLVMQASEG PMKIQTLPNM RSGAASQTKG SKIHPVGPDW SPSNADLFPS
QGSASAPQST GNALDQVDDG EVPLREKEKK VRPFSMFDAV DQSTAPPSFG TLRKNQSSED
ILRDAQVANK NVAKVPPPVP TKPKQINLPY FGQTNQPPSD IKPDGSSQQL STVVPSMGTK
PKPAGQQPRV LLSPSIPSVG QDQTLSPGSK QESPPAAAVR PFTPQPSKDT LLPPFRKPQT
VAASSIYSMY TQQQAPGKNF QQAVQSALTK THTRGPHFSS VYGKPVIAAA QNQQQHPENI
YSNSQGKPGS PEPETEPVSS VQENHENERI PRPLSPTKLL PFLSNPYRNQ SDADLEALRK
KLSNAPRPLK KRSSITEPEG PNGPNIQKLL YQRTTIAAME TISVPSYPSK SASVTASPES
PVEIQNPYLH VEPEKEVVSL VPESLSPEDV GSASTENSDM PAPSPGLDYE PEGVPDNSPN
LQNNPEEPDP EAPHLLDVYL EEYPPYPPPP YPSGEPEGPG EDSVSMRPPE ITGQVSLPPG
KRTNLRKTGS ERIAHGMRVK FNPLALLLDS SLEGEFDLVQ RIIYEVDDPS LPNDEGITAL
HNAVCAGHTE IVKFLVQFGV NVNAADSDGW TPLHCAASCN NVQVCKFLVE SGAAVFAMTY
SDMQTAADKC EEMEEGYTQC SQFLYGVQEK MGIMNKGVIY ALWDYEPQND DELPMKEGDC
MTIIHREDED EIEWWWARLN DKEGYVPRNL LGLYPRIKPR QRSLA
//