ID G3QMM9_GORGO Unreviewed; 552 AA.
AC G3QMM9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
GN Name=INTS14 {ECO:0000313|Ensembl:ENSGGOP00000003771.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000003771.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030096786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030096787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030096788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QMM9; -.
DR STRING; 9593.ENSGGOP00000003771; -.
DR Ensembl; ENSGGOT00000003861.3; ENSGGOP00000003771.3; ENSGGOG00000003838.3.
DR GeneTree; ENSGT00390000009486; -.
DR HOGENOM; CLU_041485_0_0_1; -.
DR InParanoid; G3QMM9; -.
DR OMA; QSSVVWI; -.
DR Proteomes; UP000001519; Chromosome 15.
DR Bgee; ENSGGOG00000003838; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..151
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 243..390
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 438..545
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
SQ SEQUENCE 552 AA; 61033 MW; 51F08592C4B85733 CRC64;
IGLRSAKKDI QSIPQPGITL SVCILIGNTG IIFIMPTVVV MDVSLSMTRP VSIEGSEEYQ
RKHLAAHGLT MLFEHMATNY KLEFTALVVF SSLWELMVPF TRDYNTLQEA LSNMDDYDKT
CLESALVGVC NIVQQEWGGA IPCQVVLVTD GCLGIGRGSL RHSLATQNQR SESNRFPLPF
PFPSKLYIMC MANLEELQST DSLECLERLI DLNNGEGQIF TIDGPLCLKN VQSMFGKLID
LAYTPFHAVL KCGHLTADVQ VFPRPEPFVV DEEIDPIPKV INTDLEIVGF IDIADISSPP
VLSRHLVLPI ALNKEGDEVG TGITDDNEDE NSANQIAGKI PNFCVLLHGS LKVEGMVAIV
QLGPEWHGML YSQADSKKKS NLMMSLFEPG PEPLPWLGKM AQLGPISDAK ENPYGEDDNK
SPFPLQPKNK RSYAQNVTVW IKPSGLQTDV QKILRNARKL PEKTQTFYKE LNRLRKAALA
FGFLDLLKGV ADMLERECTL LPETAHPDAA FQLTHAAQQL KLASTGTSEY AAYDQNITPL
HTDFSGSSTE RI
//