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Database: UniProt
Entry: G3QMM9_GORGO
LinkDB: G3QMM9_GORGO
Original site: G3QMM9_GORGO 
ID   G3QMM9_GORGO            Unreviewed;       552 AA.
AC   G3QMM9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE   AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
GN   Name=INTS14 {ECO:0000313|Ensembl:ENSGGOP00000003771.3};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000003771.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000003771.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC       involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC       in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the INTS14 family.
CC       {ECO:0000256|ARBA:ARBA00007451}.
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DR   EMBL; CABD030096786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030096787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030096788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G3QMM9; -.
DR   STRING; 9593.ENSGGOP00000003771; -.
DR   Ensembl; ENSGGOT00000003861.3; ENSGGOP00000003771.3; ENSGGOG00000003838.3.
DR   GeneTree; ENSGT00390000009486; -.
DR   HOGENOM; CLU_041485_0_0_1; -.
DR   InParanoid; G3QMM9; -.
DR   OMA; QSSVVWI; -.
DR   Proteomes; UP000001519; Chromosome 15.
DR   Bgee; ENSGGOG00000003838; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0034472; P:snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR039841; INTS14.
DR   InterPro; IPR045814; IntS14_b-barrel.
DR   InterPro; IPR046471; IntS14_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR   PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR   Pfam; PF19435; IntS14_b-barrel; 1.
DR   Pfam; PF20504; IntS14_C; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..151
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|Pfam:PF13519"
FT   DOMAIN          243..390
FT                   /note="Integrator complex subunit 14 beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF19435"
FT   DOMAIN          438..545
FT                   /note="Integrator complex subunit 14 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF20504"
SQ   SEQUENCE   552 AA;  61033 MW;  51F08592C4B85733 CRC64;
     IGLRSAKKDI QSIPQPGITL SVCILIGNTG IIFIMPTVVV MDVSLSMTRP VSIEGSEEYQ
     RKHLAAHGLT MLFEHMATNY KLEFTALVVF SSLWELMVPF TRDYNTLQEA LSNMDDYDKT
     CLESALVGVC NIVQQEWGGA IPCQVVLVTD GCLGIGRGSL RHSLATQNQR SESNRFPLPF
     PFPSKLYIMC MANLEELQST DSLECLERLI DLNNGEGQIF TIDGPLCLKN VQSMFGKLID
     LAYTPFHAVL KCGHLTADVQ VFPRPEPFVV DEEIDPIPKV INTDLEIVGF IDIADISSPP
     VLSRHLVLPI ALNKEGDEVG TGITDDNEDE NSANQIAGKI PNFCVLLHGS LKVEGMVAIV
     QLGPEWHGML YSQADSKKKS NLMMSLFEPG PEPLPWLGKM AQLGPISDAK ENPYGEDDNK
     SPFPLQPKNK RSYAQNVTVW IKPSGLQTDV QKILRNARKL PEKTQTFYKE LNRLRKAALA
     FGFLDLLKGV ADMLERECTL LPETAHPDAA FQLTHAAQQL KLASTGTSEY AAYDQNITPL
     HTDFSGSSTE RI
//
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