ID G3QPT0_GORGO Unreviewed; 338 AA.
AC G3QPT0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Mitochondrial glutathione transporter SLC25A40 {ECO:0000256|RuleBase:RU369018};
DE AltName: Full=Solute carrier family 25 member 40 {ECO:0000256|RuleBase:RU369018};
GN Name=SLC25A40 {ECO:0000313|Ensembl:ENSGGOP00000004581.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004581.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004581.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004581.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004581.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mitochondrial transporter required for glutathione import
CC into mitochondria. Glutathione, which plays key roles in oxidative
CC metabolism, is produced exclusively in the cytosol and is imported in
CC many organelles. Mitochondrial glutathione is required for the activity
CC and stability of proteins containing iron-sulfur clusters, as well as
CC erythropoiesis. {ECO:0000256|RuleBase:RU369018}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU369018}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU369018}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369018}.
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DR EMBL; CABD030053708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004045741.1; XM_004045693.2.
DR AlphaFoldDB; G3QPT0; -.
DR STRING; 9593.ENSGGOP00000004581; -.
DR Ensembl; ENSGGOT00000004700.3; ENSGGOP00000004581.2; ENSGGOG00000004674.3.
DR GeneID; 101142403; -.
DR KEGG; ggo:101142403; -.
DR CTD; 55972; -.
DR eggNOG; KOG0761; Eukaryota.
DR GeneTree; ENSGT00940000160249; -.
DR HOGENOM; CLU_015166_0_0_1; -.
DR InParanoid; G3QPT0; -.
DR OMA; YWWGYES; -.
DR OrthoDB; 3490716at2759; -.
DR TreeFam; TF314720; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000004674; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0048821; P:erythrocyte development; IEA:Ensembl.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IEA:InterPro.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 2.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR045315; Mtm1-like.
DR PANTHER; PTHR45760; FI19922P1-RELATED; 1.
DR PANTHER; PTHR45760:SF5; MITOCHONDRIAL GLUTATHIONE TRANSPORTER SLC25A40-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|RuleBase:RU369018};
KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU369018};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU369018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|RuleBase:RU369018};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 103..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT TRANSMEM 142..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369018"
FT REPEAT 13..131
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 139..223
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 233..327
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 338 AA; 38159 MW; 8510F84322204D1B CRC64;
MDAETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL PKGKCFVYSN
GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI KSLWSGLPPT LVMAVPATVI
YFTCYDQLSA LLRSKLGENE TYIPIVAGIV ARFGAVTVIS PLELIRTKMQ SKKFSYVELH
RFVSKKVSED GWISLWRGWA PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT
SGALSGSFAA VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF
SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY
//
