ID G3QPZ9_GORGO Unreviewed; 856 AA.
AC G3QPZ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Paladin {ECO:0000256|ARBA:ARBA00040012};
GN Name=PALD1 {ECO:0000313|Ensembl:ENSGGOP00000004656.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004656.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004656.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004656.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004656.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the paladin family.
CC {ECO:0000256|ARBA:ARBA00037958}.
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DR EMBL; CABD030070125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030070126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030070127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018890977.1; XM_019035432.1.
DR AlphaFoldDB; G3QPZ9; -.
DR STRING; 9593.ENSGGOP00000004656; -.
DR Ensembl; ENSGGOT00000004775.3; ENSGGOP00000004656.3; ENSGGOG00000004747.3.
DR KEGG; ggo:101141561; -.
DR eggNOG; ENOG502QQ90; Eukaryota.
DR GeneTree; ENSGT00390000005448; -.
DR HOGENOM; CLU_008167_0_0_1; -.
DR InParanoid; G3QPZ9; -.
DR OMA; WLCTHPE; -.
DR TreeFam; TF332292; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000004747; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR CDD; cd17659; PTP_paladin_1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR23339:SF96; PALADIN; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF14566; PTPlike_phytase; 2.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01301; PTPlike_phytase; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 262..384
FT /note="Protein-tyrosine phosphatase catalytic"
FT /evidence="ECO:0000259|SMART:SM00404"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 96661 MW; 3836A5CA4FF38D44 CRC64;
MGTTASTAQQ TVSAGTPFEG LQGSGTMDNR HSVSVHSFQT TSLHNSKAKS IIPNKVAPVV
ITYNCKEEFQ IHDELLKAHY TLGRLSDTTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA
PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY
TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLRGEPHAVA
IRGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLET QLDAFVSVLR ETPSLLQLRD
AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS
FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRLESPAQG SGSQHSIWQR
ALRSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA
RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR
KVVWVSLREE AVLECDGHTH SLRWPGPPVA PNQLETLEAQ LKAHLSEPPP GKEGPPTYRF
QTCLTMQEIF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS
CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH
RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRSLQLR SLQYLERYVC
LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW
QEQSCSLEPS APEDLL
//
