ID G3QQ69_GORGO Unreviewed; 2100 AA.
AC G3QQ69;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN Name=CACNA1B {ECO:0000313|Ensembl:ENSGGOP00000004729.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000004729.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000004729.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000004729.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000004729.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. This alpha-1B subunit gives rise to N-type
CC calcium currents. N-type calcium channels belong to the 'high-voltage
CC activated' (HVA) group. They are involved in pain signaling. Calcium
CC channels containing alpha-1B subunit may play a role in directed
CC migration of immature neurons. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1B subfamily. {ECO:0000256|ARBA:ARBA00005685}.
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DR EMBL; CABD030067536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067538; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030067545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000004851.3; ENSGGOP00000004729.3; ENSGGOG00000004807.3.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000155275; -.
DR HOGENOM; CLU_000540_1_0_1; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000004807; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005447; VDCC_N_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF6; VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01631; NVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 985..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1046..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1158..1183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1239..1257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1269..1292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1304..1328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1349..1378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1447..1470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1486..1521
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 655..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1678..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1743..1967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1678..1707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1776..1806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1825
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 219
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 569
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1129
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2100 AA; 236077 MW; 278EB3BE1692003D CRC64;
PFEYMILATI IANCIVLALE QHLPDGDKTP MSERLDDTEP YFIGIFCFEA GIKIIALGFV
FHKGSYLRNG WNVMDFVVVL TGILATAGTD FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS
IMKAMVPLLQ IGLLLFFAIL MFAIIGLEFY MGKFHKACFP NSTDAEPVGD FPCGKEAPAR
LCEGDTECRE YWPGPNFGIT NFDNILFAIL TVFQCITMEG WTDILYNTND AAGNTWNWLY
FIPLIIIGSF FMLNLVLGVL SGEFAKERER VENRRAFLKL RRQQQIEREL NGYLEWIFKA
EEVMLAEEDR NAEEKSPLDA VLKRAATKKS RNDLIHAEEG EDRFADLCAV GSPFARASLK
SGKTESSSYF RRKEKMFRFF IRRMVKAQSF YWVVLCVVAL NTLCVAMVHY NQPRRLTTAL
YFAEFVFLGL FLTEMSLKMY GLGPRSYFRS SFNCFDFGVI VGSVFEVVWA AIKPGSSFGI
SVLRALRLLR IFKVTKYWSS LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ
FNFQDETPTT NFDTFPAAIL TVFQILTGED WNAVMYHGIE SQGGVSKGMF SSFYFIVLTL
FGNYTLLNVF LAIAVDNLAN AQELTKDEEE MEEAANQKLA LQKAKEVAEV SPMSAANISI
AAPPEARSER GRGPGPEGGR RHHRRGSPEE AAEREPRRHR AHRHQDPSKE CAGAKGERRA
RHRGGPRAGP REAESGEEPA RRHRARHKAQ PAHEAVEKEA TEKEATEKEA EIVEADKEKE
LRNHQPREPH CDLETSGTVT VGPMHTLPST CLQKVEEQPE DADNQRNVTR MGSQTPDPNT
IVHIPVMLTG PPGEATVVPS GNVDLESQAE GKKEVEADDV MRSGPRPIVP YSSMFCLSPT
NLLRRFCHYI VTMRYFEMVI LVVIALSSIA LAAEDPVHTD SPRNNALKYL DYIFTGVFTF
EMVIKMIDLG LLLHPGAYFR DLWNILDFIV VSGALVAFAF SGSKGKDINT IKSLRVLRVL
RPLKTIKRLP KLKAVFDCVV NSLKNVLNIL IVYMLFMFIF AVIAVQLFKG KFFYCTDESK
ELERDCRGQY LDYEKEEVEA QPRQWKKYDF HYDNVLWALL TLFTVSTGEG WPMVLKHSVD
ATYEEQGPSP GYRMELSIFY VVYFVVFPFF FVNIFVALII ITFQEQGDKV MSECSLEKNE
RACIDFAISA KPLTRYMPQN RQSFQYKTWT FVVSPPFEYF IMAMIALNTV VLMMKFYDAP
YEYELMLKCL NIVFTSMFSM ECVLKIIAFG VLNYFRDAWN VFDFVTVLGS ITDILVTEIA
NNFINLSFLR LFRAARLIKL LRQGYTIRIL LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM
QVFGNIALDD DTSINRHNNF RTFLQALMLL FRSATGEAWH EIMLSCLSNQ ACDEQANATE
CGSDFAYFYF VSFIFLCSFL MLNLFVAVIM DNFEYLTRDS SILGPHHLDE FIRVWAEYDP
AACGRISYND MFEMLKHMSP PLGLGKKCPA RVAYKRLVRM NMPISNEDMT VHFTSTLMAL
IRTALEIKLA PAGTKQHQCD AELRKEISVV WANLPQKTLD LLVPPHKPDE MTVGKVYAAL
MIFDFYKQNK TTRDQMQQAP GGLSQMGPVS LFHPLKATLE QTQPAVLRGA RVFLRQKSST
SLSNGGAIQN QESGIKESVS WGTQRTQDAP HEARPPLERG HSTEIPVGRS GALAVDVQMQ
SITRRGPDGE PQPGLESQGR AASMPRLAAE TQPVTDASPM KRSISTLAQR PRGTHLCSTT
PDRPPPSQAS HHHHHRCHRR RDRKQRSLEK GPSLSADMDG APSSAAGPGL APGEGPTGCR
RERERRQERG RSQERRQPSS SSSEKQRFYS CDRFGGREPP KPKPSLSSHP TSPTAGQEPG
PHPQGSGSVN GSPLLSTSGA STPGRGGRRQ LPQTPLTPRP SITYKTANSS PIHFAGAQTS
LPAFSPGRLS RGLSEHNALL QRDPLSQPLA PGSRIGSDPY LGQRLDSEAS VHALPEDTLT
FEEAVATNSG RSSRTSYVSS LTSQSHPLRR VPNGYHCTLG LSSGGRARHS YHHPDQDHWC
//