ID G3QVB2_GORGO Unreviewed; 1186 AA.
AC G3QVB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=SEC24 homolog B, COPII coat complex component {ECO:0000313|Ensembl:ENSGGOP00000006676.3};
GN Name=SEC24B {ECO:0000313|Ensembl:ENSGGOP00000006676.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000006676.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; CABD030032643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030032647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QVB2; -.
DR Ensembl; ENSGGOT00000006849.3; ENSGGOP00000006676.3; ENSGGOG00000006806.3.
DR GeneTree; ENSGT00950000182924; -.
DR HOGENOM; CLU_004589_2_0_1; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000006806; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803:SF42; PROTEIN TRANSPORT PROTEIN SEC24B; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 1020..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 548..584
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 621..860
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 865..949
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 960..1033
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 1059..1132
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 199..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..397
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1186 AA; 129029 MW; B5EFB7B794704708 CRC64;
MSAPAGSSHP AAIISLQIPV NTCFSFSGPA QNQMQVPSGY GLHHQNYIAP SGHYSQGPGK
MTSLPLDTQC GDYYSALYTV PTQNVTPNTV NQQPGAQQLY SRGPPAPHIV GSTLGSFQGA
ASSASHLHTS ASQPYSSFVN HYNSPAMYSA SSSVASQGFP STCGHYAVST VSNAAYPSVS
YPSLPAGDTY GQMFTSQNAP TVRPVKDNSF SGQNTAISHP SPLPPPPSQQ HHQQQSLSGY
NTLTWSSPGL PSTPDNLIRN HTGSLAVANN NPTITDSLSC PVMQNVQPPK SSPVVSTVLS
GSSGSSSTRT PPTANHPVEP VTSVTQPSEL LQQKGVDSSS TTSSVSPMPN SYDALEGGSY
PDMLSSSASS PAPDPAPEPD PASAPAPASA PAPVVPQPSK MAKPFGYGYP TLQPGYQNAT
APLISGVQPS NPVYSGFQQY PQQYPGVNQL SSSIGGLSLQ SSPQPESLRP VNLTQERNIL
PMTPVWAPVP NLNADLKKLN CSPDSFRCTL TNIPQTQALL NKAKLPLGLL LHPFRDLTQL
PVITSNTIVR CRSCRTYINP FVSFIDQRRW KCNLCYRVND VPEEFMYNPL TRSYGEPHKR
PEVQNSTVEF IASSDYMLRP PQPAVYLFVL DVSHNAVEAG YLTILCQSLL ENLDKLPGDS
RTRIGFMTFD STIHFYNLQE GLSQPQMLIV SDIDDVFLPT PDSLLVNLYE SKELIKDLLN
ALPNMFTNTR ETHSALGPAL QAAFKLMSPT GGRVSVFQTQ LPSLGAGLLQ SREDPNQRSS
TKVVQHLGPA TDFYKKLALD CSGQQTAVDL FLLSSQYSDL ASLACMSKYS AGCIYYYPSF
HYTHNPSQAE KLQKDLKRYL TRKIGFEAVM RIRCTKGLSM HTFHGNFFVR STDLLSLANI
NPDAGFAVQL SIEESLTDTS LVCFQTALLY TSSKGERRIR VHTLCLPVVS SLADVYAGVD
VQAAICLLAN MAVDRSISSS LSDARDALVN AVVDSLSAYG STVSNLQHSA LMAPSSLKLF
PLYVLALLKQ VAFYTLLYLI LFFKILRYGA VHVNDRVVPQ PPLQKLSAEK LTREGAFLMD
CGSVFYIWVG KGCDNNFIED VLGYTNFASI PQKMTHLPEL DTLSSERARS FITWLRDSRP
LSPILHIVKD ESPAKAEFFQ HLIEDRTEAA FSYYEFLLHV QQQICK
//