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Database: UniProt
Entry: G3QVB2_GORGO
LinkDB: G3QVB2_GORGO
Original site: G3QVB2_GORGO 
ID   G3QVB2_GORGO            Unreviewed;      1186 AA.
AC   G3QVB2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=SEC24 homolog B, COPII coat complex component {ECO:0000313|Ensembl:ENSGGOP00000006676.3};
GN   Name=SEC24B {ECO:0000313|Ensembl:ENSGGOP00000006676.3};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000006676.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000006676.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC       vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC       protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC       {ECO:0000256|ARBA:ARBA00008334}.
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DR   EMBL; CABD030032643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030032644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030032645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030032646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030032647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G3QVB2; -.
DR   Ensembl; ENSGGOT00000006849.3; ENSGGOP00000006676.3; ENSGGOG00000006806.3.
DR   GeneTree; ENSGT00950000182924; -.
DR   HOGENOM; CLU_004589_2_0_1; -.
DR   Proteomes; UP000001519; Chromosome 4.
DR   Bgee; ENSGGOG00000006806; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd01479; Sec24-like; 1.
DR   Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR   Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR006900; Sec23/24_helical_dom.
DR   InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR   InterPro; IPR006896; Sec23/24_trunk_dom.
DR   InterPro; IPR012990; Sec23_24_beta_S.
DR   InterPro; IPR041742; Sec24-like_trunk_dom.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR006895; Znf_Sec23_Sec24.
DR   InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR   PANTHER; PTHR13803:SF42; PROTEIN TRANSPORT PROTEIN SEC24B; 1.
DR   PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF08033; Sec23_BS; 1.
DR   Pfam; PF04815; Sec23_helical; 1.
DR   Pfam; PF04811; Sec23_trunk; 1.
DR   Pfam; PF04810; zf-Sec23_Sec24; 1.
DR   SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR   SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        1020..1043
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          548..584
FT                   /note="Zinc finger Sec23/Sec24-type"
FT                   /evidence="ECO:0000259|Pfam:PF04810"
FT   DOMAIN          621..860
FT                   /note="Sec23/Sec24 trunk"
FT                   /evidence="ECO:0000259|Pfam:PF04811"
FT   DOMAIN          865..949
FT                   /note="Sec23/Sec24 beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF08033"
FT   DOMAIN          960..1033
FT                   /note="Sec23/Sec24 helical"
FT                   /evidence="ECO:0000259|Pfam:PF04815"
FT   DOMAIN          1059..1132
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
FT   REGION          199..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..350
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..397
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1186 AA;  129029 MW;  B5EFB7B794704708 CRC64;
     MSAPAGSSHP AAIISLQIPV NTCFSFSGPA QNQMQVPSGY GLHHQNYIAP SGHYSQGPGK
     MTSLPLDTQC GDYYSALYTV PTQNVTPNTV NQQPGAQQLY SRGPPAPHIV GSTLGSFQGA
     ASSASHLHTS ASQPYSSFVN HYNSPAMYSA SSSVASQGFP STCGHYAVST VSNAAYPSVS
     YPSLPAGDTY GQMFTSQNAP TVRPVKDNSF SGQNTAISHP SPLPPPPSQQ HHQQQSLSGY
     NTLTWSSPGL PSTPDNLIRN HTGSLAVANN NPTITDSLSC PVMQNVQPPK SSPVVSTVLS
     GSSGSSSTRT PPTANHPVEP VTSVTQPSEL LQQKGVDSSS TTSSVSPMPN SYDALEGGSY
     PDMLSSSASS PAPDPAPEPD PASAPAPASA PAPVVPQPSK MAKPFGYGYP TLQPGYQNAT
     APLISGVQPS NPVYSGFQQY PQQYPGVNQL SSSIGGLSLQ SSPQPESLRP VNLTQERNIL
     PMTPVWAPVP NLNADLKKLN CSPDSFRCTL TNIPQTQALL NKAKLPLGLL LHPFRDLTQL
     PVITSNTIVR CRSCRTYINP FVSFIDQRRW KCNLCYRVND VPEEFMYNPL TRSYGEPHKR
     PEVQNSTVEF IASSDYMLRP PQPAVYLFVL DVSHNAVEAG YLTILCQSLL ENLDKLPGDS
     RTRIGFMTFD STIHFYNLQE GLSQPQMLIV SDIDDVFLPT PDSLLVNLYE SKELIKDLLN
     ALPNMFTNTR ETHSALGPAL QAAFKLMSPT GGRVSVFQTQ LPSLGAGLLQ SREDPNQRSS
     TKVVQHLGPA TDFYKKLALD CSGQQTAVDL FLLSSQYSDL ASLACMSKYS AGCIYYYPSF
     HYTHNPSQAE KLQKDLKRYL TRKIGFEAVM RIRCTKGLSM HTFHGNFFVR STDLLSLANI
     NPDAGFAVQL SIEESLTDTS LVCFQTALLY TSSKGERRIR VHTLCLPVVS SLADVYAGVD
     VQAAICLLAN MAVDRSISSS LSDARDALVN AVVDSLSAYG STVSNLQHSA LMAPSSLKLF
     PLYVLALLKQ VAFYTLLYLI LFFKILRYGA VHVNDRVVPQ PPLQKLSAEK LTREGAFLMD
     CGSVFYIWVG KGCDNNFIED VLGYTNFASI PQKMTHLPEL DTLSSERARS FITWLRDSRP
     LSPILHIVKD ESPAKAEFFQ HLIEDRTEAA FSYYEFLLHV QQQICK
//
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