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Database: UniProt
Entry: G3QVG7_GORGO
LinkDB: G3QVG7_GORGO
Original site: G3QVG7_GORGO 
ID   G3QVG7_GORGO            Unreviewed;       612 AA.
AC   G3QVG7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 {ECO:0000313|Ensembl:ENSGGOP00000006736};
GN   Name=HCN2 {ECO:0000313|Ensembl:ENSGGOP00000006736};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006736, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000006736, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000006736}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000006736}.
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DR   STRING; 9593.ENSGGOP00000006736; -.
DR   Ensembl; ENSGGOT00000006913; ENSGGOP00000006736; ENSGGOG00000006884.
DR   GeneTree; ENSGT00900000140801; -.
DR   InParanoid; G3QVG7; -.
DR   OMA; CPQVARP; -.
DR   OrthoDB; EOG091G0JQU; -.
DR   TreeFam; TF318250; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   Bgee; ENSGGOG00000006884; -.
DR   GO; GO:0098855; C:HCN channel complex; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005222; F:intracellular cAMP activated cation channel activity; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071321; P:cellular response to cGMP; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:Ensembl.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM     21     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     49     68       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    242    265       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      343    449       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   612 AA;  69415 MW;  41EEA05054E89F0F CRC64;
     FSLRMFGSQK AVEREQERVK SAGAWIIHPY SDFIIIPVGI TFFKDETTAL WIVFNVVSDT
     FFLMDLVLNF RTGIVIEDNT EIILDPEKIK KKYLRTWFVV DFVSSIPVDY IFLIVEKGID
     SEVYKTARAL RIVRFTKILS LLRLLRLSRL IRYIHQWEEA SAVMRICNLI SMMLLLCHWD
     GCLQFLVPML QDFPRNCWVS INGMVNHSWS ELYSFALFKA MSHMLCIGYG RQAPESMTDI
     WLTMLSMIVG ATCYAMFIGH ATALIQSLDS SRRQYQEKYK QVEQYMSFHK LPADFRQKIH
     DYYEHRYQGK MFDEDSILGE LNGPLREEIV NFNCRKLVAS MPLFANADPN FVTAMLTKLK
     FEVFQPGDYI IREGTIGKKM YFIQHGVVSV LTKGNKEMKL SDGSYFGEIC LLTRGRRTAS
     VRADTYCRLY SLSVDNFNEV LEEYPMMRRA FETVAIDRLD RIGKKNSILL HKVQHDLNSG
     VFNNQENAII QEIVKYDREM VQQAELGQRV GLFPPPPPPQ VTSAIATLQQ AVAMSFCPQV
     ARPLVGPLAL GSPRLVRRPP PGPAPAAASP GPPPPASPPG APASPRAPRT SPYGSLPAAP
     LAGTALPARR LS
//
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