ID G3QY71_GORGO Unreviewed; 5546 AA.
AC G3QY71;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000007801.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000007801.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000007801.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000007801.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CABD030084042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000007801; -.
DR Ensembl; ENSGGOT00000008011.3; ENSGGOP00000007801.3; ENSGGOG00000007949.3.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000156707; -.
DR InParanoid; G3QY71; -.
DR OMA; EFHYVDT; -.
DR TreeFam; TF354317; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000007949; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0044666; C:MLL3/4 complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR CDD; cd15695; ePHD1_KMT2D; 1.
DR CDD; cd15698; ePHD2_KMT2D; 1.
DR CDD; cd22027; HMG-box_KMT2D; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15597; PHD3_KMT2D; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15601; PHD5_KMT2D; 1.
DR CDD; cd19209; SET_KMT2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041961; KMT2D_ePHD1.
DR InterPro; IPR041964; KMT2D_ePHD2.
DR InterPro; IPR047000; KMT2D_PHD3.
DR InterPro; IPR046999; KMT2D_PHD5.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037890; SET_KMT2D.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE 2D; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 7.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00184; RING; 6.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 104..218
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 226..276
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 229..274
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 273..323
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1368..1421
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1418..1468
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1495..1550
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 5038..5146
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 5406..5522
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 5530..5546
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..1322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1784..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1895..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2156..2674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2688..2968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3068..3126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3138..3200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3254..3330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3453..3490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3587..3665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3751..3795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3995..4199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4245..4412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4515..4556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4615..4736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4831..4866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4914..4989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3708..3743
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3890..3988
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..477
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..713
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..883
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..908
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..935
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..1012
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1043
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1624..1680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1735..1758
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1799..1833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2198
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2337..2389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2400..2419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2433..2467
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2536..2555
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2561..2598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2648..2668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2720..2741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2797..2820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3154..3173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3255..3280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3289..3308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3453..3478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3587..3621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3774..3789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4032..4061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4103..4146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4153..4177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4245..4269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4315..4333
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4334..4348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4349..4365
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4397..4412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4526..4556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4629..4643
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4656..4679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4836..4850
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4918..4965
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4971..4989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5546 AA; 594369 MW; DA6CDA7E31BCDCE6 CRC64;
MDSQKLAGED KDSEPAADGP AASEDPSATE SDLPNPHVGE VSVLSSGSPR LQETPQDCSG
GPVRRCALCN CGEPSLHGQR ELRRFELPFD WPRCPVVSPG GSPGPNEAVL PSEDLSQIGF
PEGLTPAHLG EPGGSCWAHH WCAAWSAGVW GQEGPELCGV DKAIFSGISQ RCSHCTRLGA
SIPCRSPGCP RLYHFPCATA SGSFLSMKTL QLLCPEHSEG AAHLEEARCA VCEGPGELCD
LFFCTSCGHH YHGACLDTAL TARKRAGWQC PECKVCQACR KPGNDSKMLV CETCDKGYHT
FCLKPPMEEL PAHSWKCKAC RVCRACGVGS AELNPNSEWF ENYSLCHRCH KAQGGQPIRS
VAEQHTPVCS RFSPPEPGDT PTDEPDALYV ACQGQPKGGH VTSMQPKEPG PLQCEAKPLG
RAGVQLEPQL EAPLNEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP PEESPASPLP
EALHLSRPPE ESPLSPPPEE SPLSPPPESS PFSPLEESPF SPPEESPPSP ALETPLSPPP
EASPLSPPFE ESPLSPPPEE LPTSPPPEAS RLSPPPEESP MSPPPEESPM SPPPEASRLF
PPFEESPLSP PPEESPLSPP PEASRLSPPP EDSPMSPPPE ESSMSPPPEV SRLSPLPVVS
RLSPPPEESP LSPPPEESPT SPPPEASRLS PPPEDSPTSP PPEDSPASPP PEDSLMSLPL
EESPLSPLPE EPQLCPMSEG PHLSPRPEEP HLSPRPEEPH LSPQAEEPCL CAVPEEPHLS
PQAEGPHLSP QPEELHLSPQ TEELHLSPVP EEPCLSPQPE ESHLSPQSEE PCLSPRPEES
HLSPQLEQPP LSPRPEEPPE EPGQCPAPEE LPLFPPPGEP SLSPLLGEPA LSEPGEPPLS
PLPEELPLSP SGEPSLSPQL MPPDPLPPPL SPIITAAAPP ALSPLGELEY PFGAKGDSDP
ESPLAAPILE TPISPPPEAN CTDPEPVPPM ILPPSPGSPV GPASPILMEP LPPQCSPLLQ
HSLVPQNSPP SQCSPPALPL SVPSPLSPIG KVVGVSDEAE LHEMETEKVS EPECPALEPS
ATSPLPSPMG DLSCPAPSPA PALDDFSGLG EDTAPLDGID AQGSQPEPGQ TPGSLASELK
GSPVLLDPEE LAPVTPMEVY PECKQTAGQG SPCEEQEEPR APVAPTPPTL IKSDIVNEIS
NLSQGDASAS FPGSEPLLGS PDPEGGGSLS MELGVSTDVS PARDEGSLRL CTDSLPETDD
SLLCDAGTAI SGGKAEGEKG RRRSSPARSR IKQGRSSSFP GRRRPRGGAH GGRGRGRARL
KSTASSIETL VVADIDSSPS KEEEEEDDDT MQNTVVLFSN TDKFVLMQDM CVVCGSFGRG
AEGHLLACSQ CSQCYHPYCV NSKITKVMLL KGWRCVECIV CEVCGQASDP SRLLLCDDCD
ISYHTYCLDP PLLTVPKGGW KCKWCVSCMQ CGAASPGFHC EWQNSYTHCG PCASLVTCPI
CHAPYVEEDL LIQCRHCERW MHAGCESLFT EDDVEQAADE GFDCVSCQPY VVKPVAPVAP
PELVPMKVKE PEPQYFRFEG VWLTETGMAL LRNLTMSPLH KRRQRRGRLG LPGEAGLEGS
EPSDALGPDD KKDGDLDTDE LLKGEGGVEH MECEIKLEGP VSPDVEPGKE ETEESKKRKR
KPYRPGIGGF MVRQRKSHTR TKKGPAAQAE VLSGDGQPDE VIPADLPAEG AVEQSLAEGD
EKKKQQRRGR KKSKLEDMFP AYLQEAFFGK ELLDLSRKAL FAVGVGRPSF GLGTPKAKGD
GGSERKELPT SQKGDDGPDI ADEESRGLEG KADTPGPEDG GVKASPVPSD PEKPGTPGEG
MLSSDLDRIS TEELPKMESK DLQQLFKDVL GSEREQHLGC GTPGLEGSRT PLQRPFLQGG
LPLGNLPSSS PMDSYPGLCQ SPFLDSRERG GFFSPEPGEP DSPWTGSGGT TPSTPTTPTT
EGEGDGLSYN QRSLQRWEKD EELGQLSTIS PVLYANINFP NLKQDYPDWS SRCKQIMKLW
RKVPAADKAP YLQKAKDNRA AHRINKVQKQ AESQINKQTK VGDIARKTDR PALHLRIPPQ
PGALGSPPPA AAPTIFIGSP TTPAGLSTSA DGFLKPPAGS VPGPDSPGEL FLKLPPQVPA
QVPSQDPFGL APAYPLEPRF PTAPPTYPPY PSPTGAPAQP PMLGASSRSG AGQPGEFHTT
PPGTPRHQPS TPDPFLKPRC PSLDNLAVPE SPGVGGGKAS EPLLSPPPFG ESRKALEVKK
EELGASSPSY GPPNLGFVDS PSSGPHLGGL ELKTPDVFKA PLTPRASQVE PQSPGLGLRP
QEPPPAQALA PSPPSHPDIF RPGSYPDPYA QPPLTPRPQP PPPESCCALP PRSLPSDPFS
RVPASPQSQS SSQSPLTPRP LSAEAFCPSP VTPRFQSPDP YSRPPSRPQS RDPFAPLHKP
PRPQPPEVAF KAGSLAHTSL GAGGFPAALP SGPAGELHAK VPSGQPPNFV RSPGTGAFVG
TPSPMRFTFP QAVGEPSLKP PVPQPGLPPP HGINSHFGPG PTLGKPQSTN YTVATGNFHP
SGSPLGPSSG STGESYGLSP LRPPSVLPPP APDGSLPYLS HGASQRSGIT SPVEKREDPG
TGMGSSLATA ELPGTQDPGM SGLSQTELEK QRQRQRLREL LIRQQIQRNT LRQEKETAAA
AAGAVGPPGS WGAEPSSPAF EQLSRGQTPF AGTQDKSSLV GLPPSKLSGP ILGPGSFPSD
DRLSRPPPPA TPSSMDVNSR QLVGGSQAFY QRAPYPGSLP LQQQQQQLWQ QQQATAATSM
RFAMSARFPS TPGPELGRQA LGSPLAGIST RLPGPGEPVP GPAGPAQFIE LRHNVQKGLG
PGGTPFPGQG PPQRPRFYPV SEDPHRLAPE GLRGLAVSGL PPQKPSAPPA PELNNSLHPT
PHTKGPTLPT GLELVNRPPS STELGRPTPL ALEAGKLPCE DPELDDDFDA HKALEDDEEL
AHLGLGVDVA KGDDELGTLE NLETNDPHLD DLLNGDEFDL LAYTDPELDT GDKKDIFNEH
LRLVESANEK AEREALLRGV EPGPLGPEER PPAAADASEP RLASVLPEVK PKVEEGGRHP
SPCQFTIATP KVEPAPAANS LGLGLKPGQS MMGSRDTRMG TGPFSSSGHT AEKASFGATG
GPPAHLLTPS PLSGPGGSSL LEKFELESGA LTLPGGPAAS GDELDKMESS LVASELPLLI
EDLLEHEKKE LQKKQQLSAQ LQPAQQQQQQ QQQHSLLSAP GPAQAMSLPH EGSSPSLAGS
QQQLSLGLAG ARQPGLPQPL MPTQPPAHAL QQRLAPSMAM VSNQGHMLSG QHGGQVGLVP
QQSSQPVLSQ KPMGTMPPSM CMKPQQLAMQ QQLANSFFPD TDLDRFAAED IIDPIAKAKM
VALKGIKKVM AQGSIGVAPG MNRQQVSLLA QRLSGGPGSD LQNHVAAGSS QERSAGDPSQ
PRPNPPTFAQ GVINEADQRQ YEEWLFHTQQ LLQMQLKVLE EQIGVHRKSR KALCAKQRTA
KKAGREFPEA DAEKLKLVTE QQSKIQKQLD QVRKQQKEHT NLMAEYRNKQ QQQQQQQQQQ
QQQQHSAVLA LSPSQSPRLL TKLPGQLLPG HGLQPPQGPP GGQAGGLRLP PGGMALPGQP
GGPFLNTALA QQQQQQHSGG AGSLAGPSGG FFPGNLALRS LGPDSRLLQE RQLQLQQQRM
QLAQKLQQQQ QQQQQQQQHL LGQVAVQQQQ QQGPGVQTNQ ALGPKPQGLL PPSSHQGLLV
QQLSPQPPQG PQGMLGPAQV AVLQQQHPGA LGPQGPHRQV LMTQSRVLSS PQLAQQGQGL
MGHRLVTAQQ QQQQQQHQQQ GSMAGLSHLQ QSLMSHSGQP KLSAQPMGSL QQLQQQQQLQ
QQQQLQQQQQ QQLQQQQQLQ QQQLQQQQQQ QQLQQQQQQQ LQQQQQQQQQ LQQQQQQLQQ
QQQQQQQLQQ QQQQLQQQQQ QQQQQMGLLN QSRTLLSPQQ QQQQQVALGP GMPAKPLQHF
SSPGALGPTL LLTGKEQNTV DPAVSSEATE GPSTHQGGPL AIGTTPESMA TEPGEVKPSL
SGDSQLLLVQ PQPQPQPSSL QLQPPLRLPG QQQQQVSLLH TAGGGSHGQL GSGSSSEASS
VPHLLAQPSV SLGDQPGPMT QNLLGPQQPM LERPMQNNTG PPQPPKPGPV LQSGQGLPGV
GIMPTVGQLR AQLQGVLAKN PQLRHLSPQQ QQQLQALLMQ RQLQQSQAVR QTPPYQEPGT
QTSPIQGPLG CQPQLGGFPG PQTGPLQELG AGPRPQGPPR LPAPPGALST GPVLGPVHPT
PPPSSPQEPK RPSQLPSPSS QLPTEAQLPP THPGTPKPQG PTLELPPGRV SPAAAQLADT
LFSKGLGPWD PPDNLAETQK PEQSSLVPGH LDQVNGQVVP EASQLSIKQE PREEPCALGV
QSVKREANGE PIGAPGTSNH LLLAGPRSEA GHLLLQKLLR AKNVQLSTGR GSEGLRAEIN
GHIDSKLAGL EQKLQGTPSN KEDAAARKPL TPKPKRVQKA SDRLVSSRKK LRKEDGVRAS
EALLKQIGGT LSPSCPAITA NFSLFAPFGS GCPVNGQSQL RGAFGSGALP TGPDYYSQLL
TKNNLSNPPT PPSSLPPTPP PSVQQKMVNG VTPSEELGEH PKDAASARDS ERALRDTSEV
KSLDLLAALP TPPHNQTEDV RMESDEDSDS PDSIVPASSP ESILGEEAPR FPHLGSGRWE
QEDRALSPVI PLIPRASIPV FPDTKPYGAL DLEVPGKLPA TTWEKGKGSE VSVMLTVSAA
AAKNLNGVMV AVAELLSMKI PNSYEVLFPE SPARAGTEPK KGEAEGPGGK EKGLGGKSPD
TGPDWLKQFD AVLPGYTLKS QLDILSLLKQ ESPAPEPPTQ HSYTYNVSNL DVRQLSAPPP
EEPSPPPSPL APSPASPPTE PLVELPAEPL AEPPVPSPLP LASSPESARP KPRARPPEEG
EDSRPPRLKK WKGVRWKRLR LLLTIQKGSG RQEDEREVAE FMEQLGTALR PDKVPRDMRR
CCFCHEEGDG ATDGPARLLN LDLDLWVHLN CALWSTEVYE TQGGALMNVE VALHRGLLTK
CSLCQRTGAT SSCNRMRCPN VYHFACAIRA KCMFFKDKTM LCPMHKIKGP CEQELSSFAV
FRRVYIERDE VKQIASIIQR GERLHMFRVG GLVFHAIGQL LPHQMADFHS ATALYPVGYE
ATRIYWSLRT NNRRCCYRCS IGENNGRPEF VIKVIEQGLE DLVFTDASPQ AVWNRIIEPV
AAMRKEADML RLFPEYLKGE ELFGLTVHAV LRIAESLPGV ESCQNYLFRY GRHPLMELPL
MINPTGCARS EPKILTHYKR PHTLNSTSMS KAYQSTFTGE TNTPYSKQFV HSKSSQYRRL
RTEWKNNVYL ARSRIQGLGL YAAKDLEKHT MVIEYIGTII RNEVANRREK IYEEQNRGIY
MFRINNEHVI DATLTGGPAR YINHSCAPNC VAEVVTFDKE DKIIIISSRR IPKGEELTYD
YQFDFEDDQH KIPCHCGAWN CRKWMN
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