GenomeNet

Database: UniProt
Entry: G3R0B9_GORGO
LinkDB: G3R0B9_GORGO
Original site: G3R0B9_GORGO 
ID   G3R0B9_GORGO            Unreviewed;       744 AA.
AC   G3R0B9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSGGOP00000008602};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008602, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000008602, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000008602}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000008602}.
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DR   STRING; 9593.ENSGGOP00000008602; -.
DR   Ensembl; ENSGGOT00000008837; ENSGGOP00000008602; ENSGGOG00000008794.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3R0B9; -.
DR   OMA; FILRANH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001519; Chromosome 7.
DR   Bgee; ENSGGOG00000008794; -.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Ensembl.
DR   GO; GO:0007588; P:excretion; IEA:Ensembl.
DR   GO; GO:0001503; P:ossification; IEA:Ensembl.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    337    361       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    381    400       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    479    500       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    506    530       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    705    730       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       27     61       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   744 AA;  85142 MW;  D4DDAA2AF5A26AD8 CRC64;
     FLEDEMQNEI VVQLLEKSPL TPLPREMITL ETVLEKLEGE LQEANQNQQA LKQSFLELTE
     LKYLLKKTQD FFETETSLAD DFFTEDTSGL LELKAVPAYM TGKLGFIAGV INRERMASFE
     RLLWRICRGN VYLKFSEMDA PLEDPVTKEE IQKNIFIIFY QGEQLRQKIK KICDGFRATV
     YPCPEPAVER REMLESVNVR LEDLITVITQ TESHRQRLLQ EAAANWHSWL IKVQKMKAVY
     HILNMCNIDV TQQCVIAEIW FPVADATRIK RALEQGMELS GSSMAPIMTT VQSKTAPPTF
     NRTNKFTAGF QNIVDAYGVG SYREINPAPY TIITFPFLFA VMFGDCGHGT VMLLAALWMI
     LNERRLLSQK TDNEIWNTFF HGRYLILLMG IFSIYTGLIY NDCFSKSLNI FGSSWSVQPM
     FRNGTWNTHV MEANLYLQLD PAIPGVYFGN PYPFGIDPIW NLASNKLTFL NSYKMKMSVI
     LGIVQMVFGV ILSLFNHIYF RRTLNIILQF IPEMIFILCL FGYLVFMIIF KWCCFDVHVS
     QHAPSILIHF INMFLFNYSD SSNAPLYKHQ QEVQSFFVVM ALISVPWMLL IKPFILRASH
     RKSQLQASRI QEDATENIEG DSSSPSSRSG QRTSADTHGA LDDHGEEFNF GDVFVHQAIH
     TIEYCLGCIS NTASYLRLWA LSLAHAQLSE VLWTMVMNSG LQTRGWGGIV GVFIIFAVFA
     VLTVAILLIM EGLSAFLHAL RLHW
//
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