ID G3R0D5_GORGO Unreviewed; 464 AA.
AC G3R0D5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DDX19B {ECO:0000313|Ensembl:ENSGGOP00000008620.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000008620.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000008620.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000008620.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000008620.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030101896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030101903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R0D5; -.
DR Ensembl; ENSGGOT00000008856.3; ENSGGOP00000008620.3; ENSGGOG00000036768.1.
DR eggNOG; KOG0332; Eukaryota.
DR GeneTree; ENSGT00940000154417; -.
DR HOGENOM; CLU_003041_1_0_1; -.
DR TreeFam; TF314957; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000036768; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 6.10.250.2170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF191; ATP-DEPENDENT RNA HELICASE DDX19B; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 77..105
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 110..280
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 291..459
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT MOTIF 77..105
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
SQ SEQUENCE 464 AA; 52267 MW; 68780D60517782E2 CRC64;
MATDSWALAV DEQEAAAESV SAVVKTSANA EKTDEEEKED RAAQSLLNKL IRSNLVDNTN
QVEVLQRDPN SPLYSVKSFE ELRLKPQLLQ GVYAMGFNRP SKIQENALPL MLAEPPQNLI
AQSQSGTGKT AAFVLAMLSQ VEPANKYPQC LCLSPTYELA LQTGKVIEQM GKFYPELKLA
YAVRGNKLER GQKISEQIVI GTPGTVLDWC SKLKFIDPKK IKVFVLDEAD VMIATQGHQD
QSIRIQRMLP RNCQMLLFSA TFEDSVWKFA QKVVPDPNVI KLKREEETLD TIKQYYVLCS
SRDEKFQALC NLYGAITIAQ AMIFCHTRKT ASWLAAELSK EGHQVALLSG EMMVEQRAAV
IERFREGKEK VLVTTNVCAR GIDVEQVSVV INFDLPVDKD RNPDNETYLH RIGRTGRFGK
RGLAVNMVDS KHSMNILNRI QEHFNKKIER LDTDDLDEIE KIAN
//
