ID G3R2H8_GORGO Unreviewed; 371 AA.
AC G3R2H8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009431.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009431.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009431.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000009431.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030057237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030057238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030057239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R2H8; -.
DR Ensembl; ENSGGOT00000009695.3; ENSGGOP00000009431.3; ENSGGOG00000009657.3.
DR GeneTree; ENSGT00940000157357; -.
DR HOGENOM; CLU_029296_1_0_1; -.
DR Proteomes; UP000001519; Chromosome 8.
DR Bgee; ENSGGOG00000009657; Expressed in adult mammalian kidney and 4 other cell types or tissues.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR14388:SF5; SH2 DOMAIN-CONTAINING PROTEIN 4A; 1.
DR PANTHER; PTHR14388; T CELL-SPECIFIC ADAPTER PROTEIN TSAD; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 264..357
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 152..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 152..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..214
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 42841 MW; 54DE2AE36AF3A2BB CRC64;
MLKQILSEMY IDPDLLAELS EEQKQILFFK MREEQIRRWK EREAAMERKE SLPVKPRPKK
GKLIHVSSVD VLVEQLLYPC LLPTTRMLSP SSSSRNIQQM LADSINRMKA YAFHQKKESM
KKKQEEEINQ IEEERTKQIC KSWKEDSEWQ ASLRKSKAAD EKRRSLAKQA REDYKRLSLG
AQKGRGGERL QSPLRIPQKP KRPPLPPKPQ FLNPGAYPQK PLRNQGLVRT VSSSAQEDII
RWFKEEQLPL RAGYQKTSDT IAPWFHGILT LKKANELLLS TGMPGSFLIR VSERIKGYAL
SHLSEDGCKH FLIDASADAY SFLGVDQLQH ATLADLVEYH KEEPITSLGK ELLLYPCGQQ
DQLPDYLELF E
//
