ID G3R2R1_GORGO Unreviewed; 375 AA.
AC G3R2R1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=C-type lectin domain family 18 member A {ECO:0008006|Google:ProtNLM};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000009522.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000009522.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000009522.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000009522.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CABD030102118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R2R1; -.
DR Ensembl; ENSGGOT00000009788.3; ENSGGOP00000009522.2; ENSGGOG00000024401.2.
DR GeneTree; ENSGT00900000141128; -.
DR HOGENOM; CLU_039012_0_0_1; -.
DR InParanoid; G3R2R1; -.
DR OMA; PANYNEH; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000024401; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 3.40.33.10; CAP; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR22801:SF61; C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER F ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR22801; LITHOSTATHINE; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF55797; PR-1-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..375
FT /note="C-type lectin domain family 18 member A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003451679"
FT DOMAIN 148..181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 226..362
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 375 AA; 41774 MW; A79E08887C74B173 CRC64;
MLHPETSPGW GHLLAVLLAL LGTTWAEVWP PQLQEQAPMA GALNRKESFL LLSLHNRLRS
WVQPPAADMR RLLVWATSSQ LGCGRHLCSA GQAAIEAFVC AYSPGGNWEV NGKTIVPYKK
GAWCSLCTAS VSGCFKAWDH AGGLCEVPRN PCRMSCQNHG RLNISTCHCH CPPGYTGRYC
QVRCSLQCVH GRFREEECSC VCDIGYGGAQ CATKVHFPFH TCDLRIDGDC FMVSSEADTY
YRARMKCQRK GGVLAQIKSQ KVQDILAFYL GRLETTNEVI DSDFETTNFW IGLTYKTAKD
SFRWATGEHQ AFTSFGFGQP DNHGLVWLSA AMGFGNCVEL QASAAFNWND QRCKTRNRYI
CQFAQEHISR WGPGS
//
