ID G3R4M6_GORGO Unreviewed; 2462 AA.
AC G3R4M6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Maltase-glucoamylase 2 (putative) {ECO:0000313|Ensembl:ENSGGOP00000010233.3};
GN Name=MGAM2 {ECO:0000313|Ensembl:ENSGGOP00000010233.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010233.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010233.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010233.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010233.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR EMBL; CABD030055577; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030055578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030055579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000010233; -.
DR Ensembl; ENSGGOT00000010532.3; ENSGGOP00000010233.3; ENSGGOG00000010479.3.
DR eggNOG; KOG1065; Eukaryota.
DR GeneTree; ENSGT00940000163091; -.
DR HOGENOM; CLU_000631_3_0_1; -.
DR InParanoid; G3R4M6; -.
DR OMA; QFTTPHS; -.
DR TreeFam; TF314577; -.
DR Proteomes; UP000001519; Chromosome 7.
DR Bgee; ENSGGOG00000010479; Expressed in testis.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004558; F:alpha-1,4-glucosidase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 2.
DR CDD; cd14752; GH31_N; 2.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 4.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030458; Glyco_hydro_31_AS.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF168; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 2.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 2.
DR Pfam; PF00088; Trefoil; 1.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 2.
DR SUPFAM; SSF57492; Trefoil; 1.
DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 851..897
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
FT REGION 1763..1848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1987..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2462 AA; 271780 MW; 964D6F93FBE59287 CRC64;
MARKLSVLEV LLIIFCLIVV TIDILLLLLV LEETSDTSFT PECPEIPQSE RIDCTPDQEV
TEVREIRSLL VAYRVLLKRN EYVKWGKEAQ SWLTATSTSQ VQVILTPQLP DVCGKEKIAS
WQRKECFSVI LALLTPWPRL DTSIGPLQFA QQYLQLSFRL PSANVYGLGE HVHQQYRHNM
TWKTWPIFTR DATPTEGMIN LYGAHTFFLC LEDASGSSFG VFLMNSNAME VTLQPAPAIT
YRTIGGILDF YVFLGNTPEQ VVQEYLELVG RPFLPPYWSL GFQLSRRDYG DINKLKEVVS
RNRLAEIPYD VQYSDIDYMD GKKDFTVDEV AYSGLPDFVK ELHDNGQKYL IIMNPGISKN
SNYEPYNNGS LKRVWILGNN GFAVGEGYPG PTVFPDYTNP VCTEWWTDQV AKFHDHLEFD
GVWIEMNEVS SLLQASNNQC ESNNLNFPPF LPRVLDHLLF ARTLCMDTEF HGGLHYDIHS
LYGHSMARTT NLALETIFMN NRSFILSRST FAGSGKFAAH WLGDNAATWD DLRWSIPTIL
EFNLFGIPMV GANICGYNNN VTEELCRRWM QLGAFYPLPR NHNGPGFRDQ DPAAFGVDSL
LLKSSRHYLN IRYTLLPYLY TLFYRAHTRG ETVARPLVHE FYQDSATWDV HEQFLWGPGL
LITPVLYEGV DEVKAYIPDA IWYDYETGVA IPWRKQLVNM LLPGDKIGLH LRGGYIFPTQ
KPNTTTEASR RNSLGLMIAL DYKREAKGEL YWDDGVSKDA VTEKKYILYD FSVTSNHLQA
KIINNNYMDT DNLMFTDITI LGMDKQPANF IVLLNNVATS SPSVVYNAST KVVTITDLQG
LVLGQEFSIR WNLPVSDLEK FNCYPDNPTA SEESCRQRGC LWEDTSTPGV PTCYYDTIPN
YVASDIQYLN TSITADLSLL MAPESAAAAA SDSLSAKISF LHLNVIYHTA TMLQVKIYDP
TNKRYEVPVP LNTPPQPVGD PENRLYDVRI QNNPFGIQIQ RKNSSAVIWD SQLPGFTFND
MFLSISTRLP SQYIYGFGET EHTTFRRNMN WNTWGMFARD EPPAYKKNSY GVHPYYMALE
EDGSAHGVLL LNSNAMDVTL QPTPALTYRT TGGILDFYIV LGPTPELVTQ QYTELIGRPA
MIPYWALGFH LSRYGYQNDA EISSLYDAMV AAQVPYDVQH VDIDYMNRKL DFTLSANFQN
LSLLIEQMKK NGMRFILVLD PAISGNETQY LPFIRGQENN VFIKWPDTND IVWGKVWPDL
PNVIVDGSLD HETQVKLYRA YVAFPDFFRN STAAWWKKEI EELYANPREP EKSLKFDGLW
IDMNEPSNFV DGSVRGCSNE MLNNPPYMPY LESRDKGLSS KTLCMESQQI LPDSSPVEHY
NVHNLYGWSQ TRPTYEAVQE VTGQRGVIIT RSTFPSSGRW GGHRLGNNTA AWDQLGKSII
GMMEFSLFGI PYTGADICGF FGDAEYEMCV RWMQLGAFYP FSRNHNNIGT RRQDPVAWNS
TFEMLSRKVL ETRYTLLPYL YTLMHKAHVE GSTVVRPLLH EFTDDRTTWD IDHQFMLGPA
ILISPVLETS TFEISAYFPR ARWYDYSTGT SSTSTGQRKI LKAPLDHINL HVRGGYILPW
QEPAMNTHSS RQNFMGLIVA LDDNGTAEGQ VFWDDGQSID TYENGNYFLA NFIAAQNILQ
IQTIHNKYLS DSNPLKVGYI RIWGVNTYVT QVSFTYDNQQ FMETNFKSEP YNQILTIQLT
DRTINLEKLT EVTWIDGGPV LPTPTKTSTI PMSSHPSPST TNATSSETIT SSASANTTTG
TTDTVPITTT SFPSTTSVTT NTTVPDTTSP FPTSTTNAST NATVPITTTP FPTSTIGVTT
NATVPNTTAP FPTNTTTAST NATVPITTTC FATSTIGVTT NATVPDTTAP FPTNTTTAST
NATIPITTTP FATSTIGVTT STTVPDTTAP FPTSTTSAST NATPVPITTT LFATSAIGVT
TGTTVPDTTA PFPTSTTGAS TSATVPITTT PSPTNTADAN TSNTVPNTTM PSPTSSTTVS
TIATIPISVT PSLTSTADAT ISTTVLIATT SSLTGTTDVS TSTTINNIST LVQTNTTNAS
TSTNVANITA TSHTGTDDTV PNNTVPVTAI PSLANTGVDT TSNSFSIMTT SFSESTNAMN
TAVIMATTSP TSTDVASTNN DASMTNFLLA TMSAGNTTSN SISITTTSFA NSVPFVTTPS
PSTDATTTSN NTIPGMTTYY QTSPTIPTHT LTSIPSSITS ILSVFPTSNT FTTDKITNFT
TPTNANTIIF NTLDTKSTMV IDATVTTTST KDNTMSPDTT VTSIDKFTTH ITQFATPHSA
TTTTLALSHT SLAPTNLSNL GTMDITDADN SSSVTGNTTH ISVSNLTTAS DTITATGLDS
QTPHMVTNSV ATYLPITATS ATTDITNITK YALNTTTPDS TVHISATAPT YIANAINATQ
VP
//
