ID G3R4S4_GORGO Unreviewed; 735 AA.
AC G3R4S4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Synapse defective Rho GTPase homolog 1 {ECO:0000313|Ensembl:ENSGGOP00000010285.2};
GN Name=SYDE1 {ECO:0000313|Ensembl:ENSGGOP00000010285.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000010285.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000010285.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000010285.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000010285.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030112014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004060240.1; XM_004060192.2.
DR AlphaFoldDB; G3R4S4; -.
DR STRING; 9593.ENSGGOP00000010285; -.
DR Ensembl; ENSGGOT00000010589.3; ENSGGOP00000010285.2; ENSGGOG00000010548.3.
DR GeneID; 101148302; -.
DR KEGG; ggo:101148302; -.
DR CTD; 85360; -.
DR eggNOG; KOG1452; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_005764_1_1_1; -.
DR InParanoid; G3R4S4; -.
DR OMA; FLQLDHT; -.
DR OrthoDB; 2905108at2759; -.
DR TreeFam; TF323458; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000010548; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0097060; C:synaptic membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:1901165; P:positive regulation of trophoblast cell migration; IEA:Ensembl.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF2; RHO GTPASE-ACTIVATING PROTEIN SYDE1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 398..604
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..695
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 79815 MW; 51611169E5668A81 CRC64;
MAEPLLRKTF SRLRGREKLP RKKSDAKERG RPAQRPEPSP PEPEPQAPEG SQAGAEGPSS
PEASRSPARG AYLQSLEPSS RRWVLGGAKP AEDTSLGPGV PGSGEPTGEI WYNPIPEEDP
RPPAPEPPGP QPGSAESEGL APQGAAPASP PTKASRTKSP GPARRLSIKM KKLPELRRRL
SLRGPRAGRE RERAAPAGSV ISRYHLDSSV GGPGPAAGPG GTRSPRAGYL SDGDSPERPA
GPPSPTSFLP YEVGPTARAP PAALWGRLSL HLYGLGGLRP APGATPRDLC CLLQVDGEAR
ARTGPLRGGP DFLRLDHTFH LELEAARLLR ALVLAWDPGV RRHRPCAQGT VLLPTVFRGC
QAQQLAVRLE PQGLLYAKLT LSEQQEAPAT AEPRVFGLPL PLLVERERPP GQVPLIIQKC
VGQIERRGLR VVGLYRLCGS AAVKKELRDA FERDSAAVCL SEDLYPDINV ITGILKDYLR
ELPTPLITQP LYKVVLEAMA RDPPNRVPPT TEGTRGLLSC LPDVERATLT LLLDHLRLVS
SFHAYNRMTP QNLAVCFGPV LLPARQAPTR PRARSSGPGL ASAVDFKHHI EVLHYLLQSW
PDPRLPRQSP DVAPYLRPKR QPPLHLPLAD PEVVTRPRGR GGPESPPSNR YAGDWSVCGR
DFLPCGRDFL SGPDYDHVTG SDSEDEDEEV GEPRVTGDFE DDFDAPFNPH LNLKDFDALI
LDLERELSKQ INVCL
//
