ID G3R8E9_GORGO Unreviewed; 879 AA.
AC G3R8E9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Solute carrier family 4 member 11 {ECO:0000313|Ensembl:ENSGGOP00000011656.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000011656.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000011656.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000011656.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000011656.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR EMBL; CABD030115311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030115312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3R8E9; -.
DR STRING; 9593.ENSGGOP00000011656; -.
DR Ensembl; ENSGGOT00000011993.3; ENSGGOP00000011656.3; ENSGGOG00000011941.3.
DR eggNOG; KOG1172; Eukaryota.
DR GeneTree; ENSGT00940000154894; -.
DR HOGENOM; CLU_002289_6_0_1; -.
DR InParanoid; G3R8E9; -.
DR OMA; AIFHWIV; -.
DR TreeFam; TF313630; -.
DR Proteomes; UP000001519; Chromosome 20.
DR Bgee; ENSGGOG00000011941; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046715; F:active borate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:0015252; F:proton channel activity; IEA:Ensembl.
DR GO; GO:0005272; F:sodium channel activity; IEA:Ensembl.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005372; F:water transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0071476; P:cellular hypotonic response; IEA:Ensembl.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:Ensembl.
DR GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR GO; GO:0050801; P:monoatomic ion homeostasis; IBA:GO_Central.
DR GO; GO:2000739; P:regulation of mesenchymal stem cell differentiation; IEA:Ensembl.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Ensembl.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 370..858
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 879 AA; 98733 MW; 67187ED97F13BC81 CRC64;
MGVYGPQDRS ESEKRDVQRD PPPWHRRREG ERPARARSLP LAAAGQGFLR KTWISEHENS
PTMSQNGYFE DSSYYKCDTD DTFEAREETL GDEAFDTANS SIVSGESIRF FVNVNLEMQA
TNSENEATSG GCVLLHTSRK YLKLKNFKEE IRAHRDLDGF LAQASIVLNE TATSLDNVLR
TMLRRFAQDP DNNEPNCNLD LLMAMLFTDA GAPMQGKVHL LSDTIQGVTA TVTGVRYQQS
WLCIICTMKA LQKRHVCISR LVRPQNWGEN SCEVRFVILV LAPPKMKSTK TAMEVARTFA
TMFSDIAFRQ KLLETRTEEE FKEALVHQRQ LLTVVSHGPV APRMKERSTV SLPAHRHPEP
PKCKDFVPFG KGIREDIARR FPLYPLDFTD GIIGKNKAVG KYITTTLFLY FACLLPTIAF
GSLNDENTDG AIDVQKTIAG QSIGGLLYAL FSGQPLVILL TTAPLALYIQ VIRVICDDYD
LDFNSFYAWT GLWNSFFLAL YAFFNLSLVM SLFKRSTEEI IALFISITFV LDAVKGMVKI
FWKYYYGHYL DDYHTKRTSS LVSLSGLGAS LNASLHTALN ASFLASPTEL PSATHSGQAT
AVLSLLIMLG TLWLGYTLYQ FKKSPYLHPC VREILSDCAL PIAVLAFSLI SSHGFREIEM
SKFRYNPSES PFTMAQIQSL SLRAISGAMG LGFLLSMLFF IEQNLVAALV NAPENRLVKG
TAYHWDLLLL AIINTGLSLF GLPWIHAAYP HSPLHVRALA LVEERVENGH IYDTIVNVKE
TRLTSLGASV LVGLSLLLLP VPLQWIPKPV LYGLFLYIAL TSLDGNQLVQ RVALLLKEQT
AYPPTHYIRR VPQRKIHYIL LPRIIEAKYL DVMDAEHRP
//
