GenomeNet

Database: UniProt
Entry: G3RA81_GORGO
LinkDB: G3RA81_GORGO
Original site: G3RA81_GORGO 
ID   G3RA81_GORGO            Unreviewed;      4421 AA.
AC   G3RA81;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSGGOP00000012340};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSGGOP00000012340};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012340, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000012340, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000012340}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000012340}.
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DR   Ensembl; ENSGGOT00000012697; ENSGGOP00000012340; ENSGGOG00000012582.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   Bgee; ENSGGOG00000012582; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3734   3753       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3954   3974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4028   4047       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4164   4185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4222   4243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4298   4321       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       19     74       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       81    126       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      134    189       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      195    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      260    317       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      463    673       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      861   1060       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3477   3512       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3866   3899       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4421 AA;  503141 MW;  C6E911E7048F0473 CRC64;
     QVDVEKWKFM MKTAQGGGHR TLLYGHAILL RHSYSGMYLC CLSTSRSSTD KLAFDVGLQE
     DTTGEACWWT IHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSYGNGSL HVDAAFQQTL
     WSVAPISSGS EAAQGYLIGG DVLRLLHGHM DECLTVPSGE HGEEQRRTVH YEGGAVSVHA
     RSLWRLETLR VAWSGSHIRW GQPFRLRHVT TGKYLSLMED KNLLLMDKEK ADVKSTAFTF
     RSSKEKLDVG VRKEVDGMGT SEIKYGDSVC YIQHVDTGLW LTYQSVDVKS VRMGSIQRKA
     IMHHEGHMDD GISLSRSQHE ESRTARVIRS TVFLFNRFIR GLDALSKKAK ASTVDLPIES
     VSLSLQDLIG YFHPPDEHLE HEDKQNRLRA LKNRQNLFQE EGMINLVLEC IDRLHVYSSA
     AHFADVAGRE AGESWKSILN SLYELLAALI RGNRKNCAQF SGSLDWLISR LERLEASSGI
     LEVLHCVLVE SPEALNIIKE GHIKSIISLL DKHGRNHKMR PNIFLGVSEG SAQYKKWYYE
     LMVDHTEPFV TAEATHLRVG WASTEGYSPY PGGGEEWGGN GVGDDLFSYG FDGLHLWSGC
     IARTVSSPNQ HLLRTDDVIS CCLDLSAPSI SFRINGQPVQ GMFENFNIDG LFFPVVSFSA
     GIKVRFLLGG RHGEFKFLPP PGYAPCYEAV LPKEKLKVEH SREYKQERTY TRDLLGPTVS
     LTQAAFTPIP VDTSQIVLPP HLERIREKLA ENIHELWVMN KIELGWQYGP VRDDNKRQHP
     CLVEFSKLPE QERNYNLQMS LETLNYQLTS GYKPAPMDLS FIKLTPSQEA MVDKLAENAH
     NVWARDRIRQ GWTYGIQQDV KNRRNPRLVP YTLLDDRTKK SNKDSLREAV RTLLGYGYNL
     EAPDQDHAAR AEVCSGTGER FRIFRAEKTY AVKAGRWYFE FETVTAGDMR VGWSRPGCQP
     DQELGSDERA FAFDGFKAQR WHQGNEHYGR SWQAGDVVGC MVDMNEHTMM FTLNGEILLD
     DSGSELAFKD FDVGDYYYSV RIFPGQEPAN VWVGWITSDF HQYDTGFDLD RVRTVTVTLG
     DEKGKVHESI KRSNCYMVCA GESMSPGQGR NNNGLEIGCV VDAASGLLTF IANGKELSTY
     YQVEPSTKLF PAVFAQATSP NVFQFELGRI KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF
     LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD ILELTEQEEL
     LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRA GYYDLLIDIH
     LSSYATARLM MNNEYIVPMT EETKSITLFP DENKKHGLPG IGLSTSLRPR MQFSSPSFVS
     ISNECYQYSP EFPLDILKSK TIQMLTEAVK EGSLHARDPV GGTTEFLFVP LIKLFYTLLI
     MGIFHNEDLK HILQLIEPSV FKEAATPEEE SDTLEKELSV DDAKLQGAGE EEAKGGKRPK
     EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA
     LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH EDLMTHCGIE
     LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQAEKPVES DSKKSSTLQQ LISETMVRWA
     QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTING VSVEDTINLL ASLGQIRSLL
     SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP
     KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN
     NELALALREP DLEKVVRYLA GCGLQSCQML VSKGYPDIGW NPVEGERYLD FLRFAVFCNG
     ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA IKIAEDPSRD GPSPNSGSSK
     TLDTEEEEDD TIHMGNAIMT FYSALIDLLG RCAPEMHLIH AGKGEAIRIR SILRSLIPLG
     DLVGVISIAF QMPTIAKDGN VVEPDMSAGF CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV
     GFLPDLRAAA SLDTAALSAT DMALALNRYL CTAVLPLLTR CAPLFAGTEH HASLIDSLLH
     TVYRLSKGCS LTKAQRDSIE VCLLSICGQL RPSMMQHLLR RLVFDVPLLN EHAKMPLKLL
     TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD ALSQKKYEQE LFKLALPCLS
     AVAGALPPDY MESNYVSMME KQSSMDSEGN FNPQPVDTSN ITIPEKLEYF INKYAEHSHD
     KWSMDKLANG WIYGEIYSDS SKVQPLMKPY KLLSEKEKEI YRWPIKESLK TMLAWGWRIE
     RTREGDSMAL YNRTRRISQT SQVSVDAAHG YSPRAIDMSN VTLSRDLHAM AEMMAENYHN
     IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK EKAKDREKAQ DILKFLQING YAVSRGFKDL
     ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI LEFDGGSRGK GEHFPYEQEI KFFAKVVLPL
     IDQYFKNHRL YFLSAASRPL CSGGHASNKE KEMVTSLFCK LGVLVRHRIS LFGNDATSIV
     NCLHILGQTL DARTVMKTGL ESVKSALRAF LDNAAEDLEK TMENLKQGQF THTRNQPKGV
     TQIINYTTVA LLPMLSSLFE HIGQHQFGED LILEDVQVSC YRILTSLYAL GTSKSIYVER
     QRSALGECLA AFAGAFPVAF LETHLDKHNI YSIYNTKSSR ERAVFSQPII NKVKPQLLKT
     HFLPLMEKLK KKAATVVSEE DHLKAEARGD MSEAELLILD EFTTLARDLY AFYPLLIRFV
     DYNRAKWLKE PNPEAEELFR MVAEVFIYWS KSHNFKREEQ NFVVQNEINN MSFLITDTKS
     KMSKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG LNICAPGDQE LIALAKNRFS
     LKDTEDEVRD IIRSNIHLQG KVGRRHYCLV EHPQRSKKAV WHKLLSKQRK RAVVACFRMA
     PLYNLPRHRA VNLFLQGYEK SWIETEEHYF EDKLIEDLAK PGAEPPEEDE GTKRVDPLHQ
     LILLFSRTAL TEKCKLEEDF LYMAYADIMA KSCHDEEDDD GEEEVKSFEE KEMEKQKLLY
     QQARLHDRGA AEMVLQTISA SKGETGPMVA ATLKLGIAIL NGGNSTVQQK MLDYLKEKKD
     VGFFQSLAGL MQSCSVLDLN AFERQNKAEG LGMVTEEGSG EKVLQDDEFT CDLFRFLQLL
     CEGHNSDFQN YLRTQTGNNT TVNIIISTVD YLLRVQESIS DFYWYYSGKD VIDEQGQRNF
     SKAIQVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM KLSQDSSQIE
     LLKELMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SNNVEMILKF FDMFLKLKDL
     TSSDTFKEYD PDGKGVISKR DFHKAMESHK HYTQSETEFL LSCAETDENE TLDYEEFVKR
     FHEPAKDIGF NVAVLLTNLS EHMPNDTRLQ TFLELAESVL NYFQPFLGRI EIMGSAKRIE
     RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNEGGEKEKM ELFVNFCEDT IFEMQLAAQI
     SESDLNERSA NKEESEKERP EEQGPRMAFF SILTVKSALF ALRYNILTLM RMLSLKSLKK
     QMKKVKKMTV KDMVTAFFSS YWSIFMTLLH FVASVFRGFF RIICSLLLGG SLVEGAKKIK
     VAELLANMPD PTQDEVRGDG EEGERKPLEA ALPSEDLTDL KELTEESDLL SDIFGLDLKR
     EGGQYKLIPH NPNAGLSDLM SNPVPMPEVQ EKFQEQKAKE EEKEEKEETK SEPEKAEGED
     GEKEEKAKED KGKQKLRQLH THRYGEPEVP ESAFWKKIIA YQQKLLNYFA RNFYNMRMLA
     LFVAFAINFI LLFYKVSTSS VVEGKELPTR SSSENAKVTS LDSSSHRIIA VHYVLEESSG
     YMEPTLRILA ILHTVISFFC IIGYYCLKVP LVIFKREKEV ARKLEFDGLY ITEQPSEDDI
     KGQWDRLVIN TQSFPNNYWD KFVKRKVMDK YGEFYGRDRI SELLGMDKAA LDFSDAREKK
     KPKKDSSLSA VLNSIDVKYQ MWKLGVVFTD NSFLYLAWYM TMSVLGHYNN FFFAAHLLDI
     AMGFKTLRTI LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDGDTPDMKC
     DDMLTCYMFH MYVGVRAGGG IGDEIEDPAG DEYEIYRIIF DITFFFFVIV ILLAIIQGLI
     IDAFGELRDQ QEQVKEDMET KCFICGIGND YFDTVPHGFE THTLQEHNLA NYLFFLMYLI
     NKDETEHTGQ ESYVWKMYQE RCWEFFPAGD CFRKQYEDQL N
//
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