ID G3RA88_GORGO Unreviewed; 1093 AA.
AC G3RA88;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 7 {ECO:0000313|Ensembl:ENSGGOP00000012351.3};
GN Name=KCNH7 {ECO:0000313|Ensembl:ENSGGOP00000012351.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000012351.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000012351.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000012351.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000012351.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABD030016697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030016704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RA88; -.
DR Ensembl; ENSGGOT00000012708.3; ENSGGOP00000012351.3; ENSGGOG00000012648.3.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000155518; -.
DR HOGENOM; CLU_005746_2_0_1; -.
DR OMA; MRTSHPV; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000012648; Expressed in frontal cortex and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF466; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 642..742
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 91..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 925..952
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 782..812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1093 AA; 123255 MW; BC6AAB52B2087CBE CRC64;
STFICNTHII PVKNQEGVAM MFIINFEYVT DNENAATPER VNPILPIKTV NRKFFGFKFP
GLRVLTYRKQ SLPQEDPDVV VIDSSKHSDD SVAMKHFKSP TKESCSPSEA DDTKALIQPS
KCSPLVNISG PLDHSSPKRQ WDRLYPDMLQ SSSQLSHSRS RESLCSIRRA SSVHDIEGFG
VHPKNIFRDR HASEDNGRNV KGPFNHIKSS LLGSTSDSNL NKYSTINKIP QLTLNFSEAK
TEKKNSSPPS SDKTIIAPKV KDRTHNVTEK VTQVLSLGAD VLPEYKLQTP RINKFTILHY
SPFKAVWDWL ILLLVIYTAI FTPYSAAFLL NDREEQKRRE CGYSCSPLNV VDLIVDIMFI
IDILINFRTT YVNQNEEVVS DPAKIAIHYF KGWFLIDMVA AIPFDLLIFG SGSDETTTLI
GLLKTARLLR LVRVARKLDR YSEYGAAVLM LLMCIFALIA HWLACIWYAI GNVERPYLTD
KIGWLDSLGQ QIGKRYNDSD SSSGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF
SICVMLIGSL MYASIFGNVS AIIQRLYSGT ARYHMQMLRV KEFIRFHQIP NPLRQRLEEY
FQHAWTYTNG IDMNMVLKGF PECLQADICL HLNQTLLQNC KAFRGASKGC LRALAMKFKT
THAPPGDTLV HCGDVLTALY FLSRGSIEIL KDDIVVAILG KNDIFGEMVH LYAKPGKSNA
DVRALTYCDL HKIQREDLLE VLDMYPEFSD HFLTNLELTF NLRHESAKAD LLRSQSMNDS
EGDNCKLRRR KLSFESEGEK ENSTNDPEDS ADTIRHYQSS KRHFEEKKSR SSSFISSIDD
EQKPLFSGIV DSSPGIGKAS GLDFEETVPT SGRVHIDKRS HSCKDITDMR SWERENAHPQ
PEDSSPSALQ RAAWGISETE SDLTYGEVEQ RLDLLQEQLN RLESQMTTDI QTILQLLQKQ
TTVVPPAYSM VTAGAEYQRP IIQLMRTSQP EASIKTDRSF SPSSQCPEFL DLEKSKLKSK
ESLSSGVHLN TASEDNLTSL LKQDSDLSLE LHLRQRKTYI HPIRHPSLPD SSLSTVGIVG
LHRHVSDPGL PGK
//
