ID G3RCN2_GORGO Unreviewed; 381 AA.
AC G3RCN2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=KRR1 small subunit processome component {ECO:0000256|PIRNR:PIRNR006515};
DE AltName: Full=KRR-R motif-containing protein 1 {ECO:0000256|PIRNR:PIRNR006515};
GN Name=KRR1 {ECO:0000313|Ensembl:ENSGGOP00000013265.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000013265.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000013265.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000013265.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000013265.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar
CC processing of pre-18S ribosomal RNA and ribosome assembly.
CC {ECO:0000256|PIRNR:PIRNR006515}.
CC -!- SUBUNIT: Component of the ribosomal small subunit (SSU) processome.
CC {ECO:0000256|PIRNR:PIRNR006515}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR006515}.
CC -!- SIMILARITY: Belongs to the KRR1 family. {ECO:0000256|ARBA:ARBA00009344,
CC ECO:0000256|PIRNR:PIRNR006515}.
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DR EMBL; CABD030085504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018894600.1; XM_019039055.1.
DR AlphaFoldDB; G3RCN2; -.
DR STRING; 9593.ENSGGOP00000013265; -.
DR Ensembl; ENSGGOT00000013646.3; ENSGGOP00000013265.3; ENSGGOG00000013596.3.
DR GeneID; 101154395; -.
DR KEGG; ggo:101154395; -.
DR CTD; 11103; -.
DR eggNOG; KOG2874; Eukaryota.
DR GeneTree; ENSGT00390000018775; -.
DR HOGENOM; CLU_040185_0_0_1; -.
DR InParanoid; G3RCN2; -.
DR OMA; HKKEKFV; -.
DR OrthoDB; 5477881at2759; -.
DR TreeFam; TF105745; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000013596; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd22393; KH-I_KRR1_rpt1; 1.
DR CDD; cd22394; KH-I_KRR1_rpt2; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR041174; KRR1-like_KH1.
DR InterPro; IPR048550; KRR1-like_KH1_euk.
DR InterPro; IPR048548; KRR1-like_KH2.
DR InterPro; IPR048549; KRR1-like_KH2_euk.
DR InterPro; IPR024166; rRNA_assembly_KRR1.
DR PANTHER; PTHR12581; HIV-1 REV BINDING PROTEIN 2, 3; 1.
DR PANTHER; PTHR12581:SF0; KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG; 1.
DR Pfam; PF17903; KH_8; 1.
DR Pfam; PF21800; KRR1-like_KH2; 1.
DR PIRSF; PIRSF006515; KRR1; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR006515};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|PIRNR:PIRNR006515};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|PIRNR:PIRNR006515};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR006515};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552,
KW ECO:0000256|PIRNR:PIRNR006515}.
FT DOMAIN 139..211
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 381 AA; 43653 MW; A2242FCC2239DCE2 CRC64;
MASPSLERPE KGAGKSEFRN QKPKPENQDE SELLTVPDGW KEPAFSKEDN PRGLLEESSF
ATLFPKYREA YLKECWPLVQ KALNEHHVNA TLDLIEGSMT VCTTKKTFDP YIIIRARDLI
KLLARSVSFE QAVRILQDDV ACDIIKIGSL VRNKERFVKR RQRLIGPKGS TLKALELLTN
CYIMVQGNTV SAIGPFSGLK EVRKVVLDTM KNIHPIYNIK SLMIKRELAK DSELRSQSWE
RFLPQFKHKN VNKRKEPKKK TVKKEYTPFP PPQPESQIDK ELASGEYFLK ANQKKRQKME
AIKAKQAEAI SKRQEERNKA FIPPKEKPTV KPKEASTETK IDVASIKEKV KKAKNKKLGA
LTAEEIALKM EADEKKKKKK K
//
