ID G3RGQ5_GORGO Unreviewed; 304 AA.
AC G3RGQ5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Solute carrier family 25 member 34 {ECO:0000256|ARBA:ARBA00040911};
GN Name=SLC25A34 {ECO:0000313|Ensembl:ENSGGOP00000014810.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000014810.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000014810.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000014810.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000014810.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative antiporter that exchanges dicarboxylates and sulfur
CC oxoanions across the inner membrane of mitochondria.
CC {ECO:0000256|ARBA:ARBA00037259}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) +
CC sulfate(in); Xref=Rhea:RHEA:76595, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:28965; Evidence={ECO:0000256|ARBA:ARBA00035937};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; CABD030001146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004024771.1; XM_004024722.2.
DR AlphaFoldDB; G3RGQ5; -.
DR Ensembl; ENSGGOT00000015233.3; ENSGGOP00000014810.3; ENSGGOG00000015182.3.
DR GeneID; 101131509; -.
DR KEGG; ggo:101131509; -.
DR CTD; 284723; -.
DR eggNOG; KOG0755; Eukaryota.
DR GeneTree; ENSGT00940000160016; -.
DR HOGENOM; CLU_015166_14_3_1; -.
DR InParanoid; G3RGQ5; -.
DR OMA; KANCEDH; -.
DR OrthoDB; 167716at2759; -.
DR TreeFam; TF324506; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000015182; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45928; RE38146P; 1.
DR PANTHER; PTHR45928:SF3; SOLUTE CARRIER FAMILY 25 MEMBER 34; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 4..97
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 101..194
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 204..295
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 304 AA; 32316 MW; 3111942262BDFBDA CRC64;
METVPPAVDL VLGASACCLA CVFTNPLEVV KTRLQLQGEL QARGTYPRPY RGFIASVAAV
ARADGLWGLQ KGLAAGLLYQ GLMNGIRFYC YSLACQAGLT QQPGGTVVAG AVAGALGAFV
GSPAYLIKTQ LQAQTVAAMA VGHQHNHQTV LGALETIWRQ QGLLGLWQGV GGAVPRVMVG
SAAQLATFAS AKAWVQKQQW LPEDSWLVAL AGGMISSIAV VVVMTPFDVV STRLYNQPVD
RAGRGQLYGG LTDCMVKIWQ QEGPLALYKG LGPAYLRLGP HTILSMLFWD ELRKLAGRAQ
HQGT
//
