ID G3RGQ7_GORGO Unreviewed; 1050 AA.
AC G3RGQ7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Integrin subunit alpha 8 {ECO:0000313|Ensembl:ENSGGOP00000014812.3};
GN Name=ITGA8 {ECO:0000313|Ensembl:ENSGGOP00000014812.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000014812.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000014812.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000014812.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000014812.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; CABD030068163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030068170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RGQ7; -.
DR Ensembl; ENSGGOT00000015236.3; ENSGGOP00000014812.3; ENSGGOG00000015171.3.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000156737; -.
DR HOGENOM; CLU_004111_4_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000015171; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..1050
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014146543"
FT TRANSMEM 999..1021
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 44..105
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 122..183
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 188..240
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 303..368
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 369..427
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 431..494
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 479..635
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 637..759
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 779..988
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1050 AA; 116325 MW; 4735978EBC5EECA1 CRC64;
MSPGASRGPR GSQAPLIAPL CCAAAALGMM LWTPACQAFN LDVEKLTVYS GPKGSYFGYA
VDFHVPDAST ASVLVGAPKA NTSQPDIMEG GAVYYCPWPA EGSAQCRQIP FDTTNNRKIR
VNGTKEPIEF KSNQWFGATV KAHKGKVVAC APLYHWRTLK PTPEKDPVGT CYVAIQNFSA
YAEFSPCRNS NADPEGQGYC QAGFSLDFYK NGDLIVGGPG SFYWQGPASC FHSVNVLILI
TASVADIIAN YSFKDILRKL AGEKQTEVAP ASYDDSYLEL VAGIPRGAQN FGYVSIINST
DMTFIQNFTG EQMASYFGYT VVVSDVNSDG LDDVLVGAPL FMEREFESNP REVGQIYLYL
QVSSLLFRDP QILTGTETFG RFGSAMAHLG DLNQDGYNDV AIGVPFAGKD QRGKVLIYNG
NKDGLNTKPS QVLQGVWASH AIPSGFGFTL RGDSDIDRND YPDLIVGAFG TGKVAVYRAR
PVVTVDAQLL LHPMIINLEN KTCQVPDSMT SAACFSLRVC ASVTGQSIAN TIVLMAEVQL
DSLKQKGAIK RTLFLDNHQA HRIFPLVIKR QKSHQCQNFI VYLRDETEFR DKLSPINISL
NYSLDESTFK EGLGVKPVLN YYRENIVSEQ AHILVDCGED NLCVPDLKLS ARPDKHQVII
GDENHLMLII NARNEGEGAY EAELFVMIPE EADYVGIERN NKGFRPLSCE YKMENVTRMV
VCDLGNPMVS GTNYSLGLRF AVPRLEKTNM SINFDLQIRR LDLYMPISLT ALKRKEIHMS
HPPQIVLPIH NWEPEEEPHK EEEVGPLVEH IYELHNIGPS TISDTILEVG WPFSARDEFL
LYIFHIQTLG PLQCQTNPNI NPQDIKPAAS PEDTPELSAF LQNSTIPHLV RKRDVHVVEF
HRQSPAKILN CTNIECLQIS CAVGQLEGGE SAVLKVRSRL WAHTFLQRKN DPYALASLVS
FEVKKMPYKD QPAKLPEGSI AIKTSVIWAT PNVSFSIPLW VIILAILLGL LVLAILTLAL
WKCGFFDRAR PPQEDMTDRE QLTNDKTPEA
//