ID G3RH65_GORGO Unreviewed; 2530 AA.
AC G3RH65;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=Zinc finger FYVE domain-containing protein 26 {ECO:0000256|ARBA:ARBA00014373};
GN Name=ZFYVE26 {ECO:0000313|Ensembl:ENSGGOP00000014981.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000014981.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000014981.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000014981.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000014981.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphatidylinositol 3-phosphate-binding protein required for
CC the abcission step in cytokinesis: recruited to the midbody during
CC cytokinesis and acts as a regulator of abcission. May also be required
CC for efficient homologous recombination DNA double-strand break repair.
CC {ECO:0000256|ARBA:ARBA00025209}.
CC -!- SUBUNIT: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with
CC TTC19 and KIF13A. {ECO:0000256|ARBA:ARBA00025962}.
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DR EMBL; CABD030092949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030092950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9593.ENSGGOP00000014981; -.
DR Ensembl; ENSGGOT00000015409.3; ENSGGOP00000014981.3; ENSGGOG00000015342.3.
DR eggNOG; KOG1811; Eukaryota.
DR GeneTree; ENSGT00920000149143; -.
DR HOGENOM; CLU_228199_0_0_1; -.
DR InParanoid; G3RH65; -.
DR OMA; DWATMAV; -.
DR TreeFam; TF324517; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000015342; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:1905037; P:autophagosome organization; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR CDD; cd15724; FYVE_ZFY26; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1803..1863
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 594..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1866..1885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2530 AA; 283286 MW; 51B89815B3DC97DB CRC64;
MNHPFGKEEA ASQKQLFGFF CECLRRGEWE LAQACVPQLQ EGQGDIPKRV EDILQALVVC
PNLLRCGQDI NPQRVAWVWL LVLEKWLARE KKLLPFVFRR KLEFLLLSED LQGDIPENIL
EELYETLTQG AVGHVPDGNP RRESWTPRLS SEAVSVLWDL LRQSPQPAQA LLELLLGEDD
GTGLCHWPLQ NALVDLIRKA LRALQGPDSV PPGVVDAIYG ALRTLRCPAE PLGVELRLLC
EELLEACRTE GSPLREERLL SCLLHKASRG LLSLYGHTYA EKVTEKPPRA TASGKVSPDH
LDPERAMLAL FSNPNPAEAW KVAYFYCLSN NKHFLEQILV TALTLLKEED FPNLGCLLDR
EFRPLSCLLV LLGWTHCQSL ESAKRLLQTL HRTQGPGCDE LLRDACDGLW AHLEVLEWCI
QQSSNPIPKR DLLYHLHGGD SHSVLYTLHH LTNLPALREE DVLKLLQKVP AKDPQQEPDA
VDAPVPEHLS QCQNLTLYQG FCAMKYAIYA LCVNSHQHSQ CQDCKDSLSE DLASATEPAN
DSLSSPGAAN LFSTYLARCQ QYLCSIPDSL CLELLENIFS LLLITSADLH PEPHLPEDYA
EDDDIEGKSP SGLRSPSESP QHIAHPERKS ERGSLGVPKT LAYTMPSHVK AEPKDSYPGP
HRHSFLDLKH FTSGISGFLA DEFTIGAFLR LLQEQLDEIS SRSPPEKPKQ ESQSCSGSRD
GLQSRLHRLS KVVSEAQWRH KVVTSNHRSG ERRVELVGPE GGEGERSQEY GREGSNPSLE
STSSELSTST SEGSLSAMSG RNELHSRLHP HPQSSLIPMM FSPPESLLAS CILRGNFAEA
HQVLFTFNLK SSPSSGELMF MERYQEVIQE LAQVEHKIEN QNSDAGSSTI RRTGSGRSTL
QAIGSAAAAG MVFYSISDVT DKLLNTSGDP IPMLQEDFWI STALVEPTAP LREVLEDLSP
PAMAAFDLAC SQCQLWKTCK QLLETAERRL NSSLERRGRR IDHVLLNADG IRGFPVVLQQ
ISKSLNYLLM SASQTKSESV EEKGGGPPRC SITELLQMCW PSLTEDCVAS HTTLSQQLDQ
VLQSLREALE LPEPRTPPLS SLVEQAAQKA PEAEAHPVQI QTQLLQKNLG KQTPSGSRQM
DYLGTFFSYC STLAAVLLQS LSSEPDHVEV KVGNPFVLLQ QSSSQLVSHL LFERQVPPER
LAALLAQENL SLSVPQVIVS CCCEPLALCS SRQSQQTSSL LTRLGTLAQL HASHCLDDLP
LSTPSSPRTT ENPILERKPY SSPRDSSLPA LTSSALTFLK SRSKLLATVA CLGASPRLKV
SKPSLSWKEL RGRREVPLAA EQVARECERL LEQFPLFEAF LLATWEPLRG SLQQGQSLAV
NLCGWASLST VLLGLHSPIA LDVLSEAFEE SLVARDWSRA LQLTEVYGRD VDDLSSIKDA
VLSCAVACDK EGWQYLFPVK DASLRSRLAL QFVDRWPLES CLEILAYCIS DTAVQEGLKC
ELQRKLAELQ VYQKILGLQS PPVWCDWQTL RSCCVEDPST VMNMILEAQE YELCEEWGCL
YPIPREHLIS LHQKHLLHLL ERRDHDKALQ LLRRIPDPTM CLEVTEQSLD QHTSLATSHF
LANYLTTHFY GQLTAVRHRE IQALYVGSKI LLTLPEQHRA SYSHLSSNPL FMLEQLLMNM
KVDWATVAVQ TLQQLLVGQE IGFTMDEVDS LLSRYAEKAL DLPYPQREKR SDSMIHLQEI
VHQAADPETL PRSPSAEFSP AAPPGISSIH SPSLRERSFP PTQPTQEFVP PATPPARHQW
VPDETESICM VCCREHFTMF NRRHHCRRCG RLVCSSCSTK KMVVEGCREN PARVCDQCYS
YCNKDVPEEP SEKPEALDSS KSESPPYSFV VRVPKADEVE WILDLKEEEN ELVRSEFYYE
QAPSASLCIA ILNLHRDSIA CGHQLIEHCC RLSKGLTNPE VDAGLLTDIM KQLLFSAKMM
FVKAGQSQDL ALCDSYISKV DVLNILVAAA YRHVPSLDQI LQPAAVTRLR NQLLEAEYYQ
LGVEVSTKTG LDTTGAWHAW GMACLKAGNL TAAREKFSRC LKLPFDLNQL NHGSRLVQDV
VEYLESTVRP LVSLQDDDYF ATLRELEATL RTQSLSLAVI PEGKIMNNTY YQECLFYLHN
YSTNLAIISF YVRHSCLREA LLHLLNKESP PEVFIEGIFQ PSYKSGKLHT LENLLESIDP
TLESWGKYLI AACQHLQKKN YYHILYELQQ FMKDQVRAAM TCIRFFSHKA KSYTELGEKL
SWLLKAKDHL KIYLQETSRS SGRKKTTFFR KKMTAADVSR HMNTLQLQME VTRFLHRCES
AGTSQITTLP LPTLFGNNHM KMDVACKVML GGKNVEDGFG IAFRVLQDFQ LDAAMTYCRA
ARQLVEKEKY SEIQQLLKCV SESGMAAKSD GDTILLNCLE AFKRIPPQEL EGLIQAIHND
DNKVRAYLIC CKLRSAYLIA VKQEHSRATA LVQQVQQAAK SSGDAVVQDI CAQWLLTSHP
QGAHGSGSRK
//
