ID G3RL23_GORGO Unreviewed; 1124 AA.
AC G3RL23;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Rho GTPase activating protein 33 {ECO:0000313|Ensembl:ENSGGOP00000016457.3};
GN Name=ARHGAP33 {ECO:0000313|Ensembl:ENSGGOP00000016457.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016457.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000016457.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000016457.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000016457.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PX domain-containing GAP family.
CC {ECO:0000256|ARBA:ARBA00008795}.
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DR EMBL; CABD030113217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RL23; -.
DR Ensembl; ENSGGOT00000016922.3; ENSGGOP00000016457.3; ENSGGOG00000016856.3.
DR GeneTree; ENSGT00940000155110; -.
DR HOGENOM; CLU_009183_0_0_1; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000016856; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR CDD; cd11835; SH3_ARHGAP32_33; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF11; RHO GTPASE-ACTIVATING PROTEIN 33; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 184..246
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 313..508
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..734
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1046
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1072
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 120891 MW; AB0F74B755F11AC6 CRC64;
ARSTDSLDGP GEGSVQPLPT AGGPSVKGKP GKRLSAPRGP FPRLADCAHF HYENVDFGHI
QLLLSPDREG PSLSGENELV FGVQVTCQGR SWPVLRSYDD FRSLDAHLHR CIFDRRFSCL
PELPPPPEGA RAAQMLVPLL LQYLETLSGL VDSNLNCGPV LTWMELDNHG RRLLLSEEAS
LNIPAVAAAH VIKRYTAQAP DELSFEVGDI VSVIDMPPTE DRSWWRGKRG FQVGFFPSEC
VELFTERPGL GLKADADGPP CGIPAPQGIS SLTSAVPRPR GKLAGLLRTF MRSRPSRQRL
RQRGILRQRV FGCDLGEHLS NSGQDVPQVL RCCSEFIEAH GVVDGIYRLS GVSSNIQRLR
HEFDSERIPE LSGPAFLQDI HSVSSLCKLY FRELPNPLLT YQLYGKFSEA MSVPGEEERL
VRVHDVIQQL PPPHYRTLEY LLRHLARMAR HSANTSMHAR NLAIVWAPNL LRSMELESVG
MGGAAAFREV RVQSVVVEFL LTHVDVLFSD TFTSAGLDPA GRCLLPRPKS LAGSCPSTRL
LTLEEAQART QGRLGTPTEP TTPKAPASPA ERRKGERGEK QRKPGGSSWK TFFALGRGPS
VPRKKPLPWL GGTRAPPQPS GSRPDTVTLR SAKSEESLSS QASGAELLGA GGAPASATPT
PALSPGRSLR PHLIPLLLRG AEAPLTDACQ QEMCSKLWGA QGPLGPDMES PLPPPPLSLL
RPGGAPPPPP KNPARLMALA LAERAQQVAE QQSQQECGGT PPAPQSPFHR SLSLEVGGEP
LGTSGSGPPP NSLAHPGAWV PGPPPYLPRQ QSDGSLLRSQ RPMGTSRRGL RGPAQVSAQL
RAGGGGRDAP EAAAQSPCSV PSQVPTPGFF SPAPRECLPP FLGVPKPGLY PLGPPSFQPS
SPAPVWRSSL GPPAPLDRGE NLYYEIGASE GSPYSGPTRS WSPFRSMPPD RLNASYGMLG
QSPPLHRSPD FLLSYPPAPS CFPPDHLGYS APQHPARRPT PPEPLYVNLA LGPRGPSPAS
SSSSSPPAHP RSRSDPGPPV PRLPQKQRAP WGPRTPHRVP GPWGPPEPLL LYRAAPPAYG
RGGELHRGSL YRNGGQRGEG AGPPPPYPTP SWSLHSEGQT RSYC
//
