GenomeNet

Database: UniProt
Entry: G3RMI4_GORGO
LinkDB: G3RMI4_GORGO
Original site: G3RMI4_GORGO 
ID   G3RMI4_GORGO            Unreviewed;      4905 AA.
AC   G3RMI4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSGGOP00000016998};
GN   Name=RYR1 {ECO:0000313|Ensembl:ENSGGOP00000016998};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000016998, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000016998, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000016998}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000016998}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 9593.ENSGGOP00000016998; -.
DR   Ensembl; ENSGGOT00000029090; ENSGGOP00000016998; ENSGGOG00000015461.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3RMI4; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   Bgee; ENSGGOG00000015461; -.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0031674; C:I band; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030314; C:junctional membrane complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IEA:Ensembl.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4424   4444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4512   4535       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4660   4684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4705   4727       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4786   4809       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      335    392       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      581    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1209       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1357   1571       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4905 AA;  550591 MW;  A1D3FD796B21277E CRC64;
     MGDAEGEDEV QFLRTDDEVV LQCSATVLKE QLKLCLAAEG FGNRLCFLEP TSNAQNVPPD
     LAICCFVLEQ SLSVRALQEM LANTVEAGVE SSQGGGHRTL LYGHAILLRH AHSRMYLSCL
     TTSRSMTDKL AFDVGLQEDA TGEACWWTMH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSTASGELQV DASFMQTLWN MNPICSRCEE GFVTGGHVLR LFHGHMDECL TISPADSDDQ
     RRLVYYEGGA VCTHARSLWR LEPLRISWSG SHLRWGQPLR VRHVTTGRYL ALTEDQGLVV
     VDASKAHTKA TSFCFRISKE KLDVAPKRDV EGMGPPEIKY GESLCFVQHV ASGLWLTYAA
     PDPKALRLGV LKKKAMLHQE GHMDDALSLT RCQQEESQAA RMIHSTNGLY NQFIKSLDSF
     SGKPRGSGPP AGTALPIEGV ILSLQDLIIY FEPPSEDLQH EEKQSKLRSL RNRQSLFQEE
     GMLSMVLNCI DRLNVYTTAA HFAEFAGEEA AESWKEIVNL LYELLASLIR GNRSNCALFS
     TNLDWLVSKL DRLEASSGIL EVLYCVLIES PEVLNIIQEN HIKSIISLLD KHGRNHKVLD
     VLCSLCVCNG VAVRSNQDLI TENLLPGREL LLQTNLINYV TSIRPNIFVG RAEGTTQYSK
     WYFEVMVDEV TPFLTAQATH LRVGWALTEG YSPYPGGGEG WGGNGVGDDL YSYGFDGLHL
     WTGHVARPVT SPGQHLLAPE DVISCCLDLS VPSISFRING CPVQGVFESF NLDGLFFPVV
     SFSAGVKVRF LLGGRHGEFK FLPPPGYAPC HEAVLPRERL HLEPIKEYRR EGPRGPHLVG
     PSRCLSHTDF VPCPVDTVQI VLPPHLERIR EKLAENIHEL WALTRIEQGW TYGPVRDDNK
     RLHPCLVDFH SLPEPERNYN LQMSGETLKT GIVRQKQMGI SGERSERVLG TATLYQRYMM
     SNGYKPAPLD LSHVRLTPAQ TTLVDRLAEN GHNVWARDRV GQGWSYSAVQ DIPARRNPRL
     VPYRLLDEAT KRSNRDSLCQ AVRTLLGYGY NIEPPDQEPS EVENQSRCDR VRIFRAEKSY
     TVQSGRWYFE FEAVTTGEMR VGWARPELRP DVELGADELA YVFNGHRGQR WHLGSEPFGR
     PWQPGDVVGC MIDLTENTII FTLNGEVLMS DSGSETAFRE IEIGDAGFLP VCSLGPGQVG
     HLNLGQDVSS LRFFAICGLQ EGFEPFAINM QRPVTTWFSK GLPQFEPVPL EHPHYEVSRV
     DGTVDTPPCL RLTHRTWGSQ NSLVEMLFLR LSLPVQFHQH FRCTAGATPL APPGLQPPAE
     DEARAAEPDP DYENLRRSAG GWGEAENGKE GTAKEGAPGG TPQAGGEAQP ARAENEKDAT
     TEKNKKRGFL FKAKKVAMMT QPPATPTLPR LPHDVVPADN RDDPEIILNT TTYYYSVRVF
     AGQEPSCVWA GWVTPDYHQH DMSFDLSKVR VVTVTMGDEQ GNVHSSLKCS NCYMVWGGDF
     VSPGQQGRIS HTDLVIGCLV DLATGLMTFT ANGKESNTFF QVEPNTKLFP AVFVLPTHQN
     VIQFELGKQK NIMPLSAAMF QSERKNPAPQ CPPRLEMQML MPVSWSRMPN HFLQVETRRA
     GERLGWAVQC QEPLTMLIRL SLSVFHLCCR CMDILELSER LDLQRFHSHT LCLYRAVCAL
     GNNRVAHALC SHVDQAQLLH ALEDAHLPGP LRAGYYDLLI SIHLESACRS RRSMLSEYIV
     PLTPETRAIT LFPPGRSTEN GHPRHGLPGV GVTTSLRPPH HFSPPCFVAA LPAAGAAEAP
     ARLSPAIPLE ALRDKALRML GEAVRDGGQH ARDPVGGSVE FQFVPVLKLV STLLVMGIFG
     DEDVKQILKM IEPEVFTAEG EKEEGLEEGL LQMKLPESVK LQMCHLLEYF CDQELQHRVE
     SLAAFAERYV DKLQANQRSR YGLLIKAFSM TAAETARRTR EFRSPPQEQI NMLLQFKDGT
     DEEDCPLPEE IRQDLLDFHQ DLLAHCGIQL DGEEEEPEEE TTLGSRLMSL LEKVRLVKKK
     EEKPEEERSA EESKPRSLQE LVSHMVVRWA QEDFVQSPEL VRAMFSLLHR QYDGLGELLR
     ALPRAYTISP SSVEDTMSLL ECLGQIRSLL IVQMGPQEEN LMIQSIGNIM NNKVFYQHPN
     LMRALGMHET VMEVMVNVLG GGESKEIRFP KMVTSCCRFL CYFCRISRQN QRSMFDHLSY
     LLENSGIGLG MQGSTPLDVA AASVIDNNEL ALALQEQDLE KVVSYLAGCG LQSCPMLVAK
     GYPDIGWNPC GGERYLDFLR FAVFVNGESV EENANVVVRL LIRKPECFGP ALRGEGGSGL
     LAAIEEAIRI SEDPARDGPG IRRDRRREHF GEEPPEENRV HLGHAIMSFY AALIDLLGRC
     APEMHLIQAG KGEALRIRAI LRSLVPLEDL VGIISLPLQI PTLGKDGALV QPKMSASFVP
     DHKASMVLFL DRVYGIENQD FLLHVLDVGF LPDMRAAASL DTATFSTTEM ALALNRYLCL
     AVLPLITKCA PLFAGTEHRA IMVDSMLHTV YRLSRGRSLT KAQRDVIEDC LMSLCRYIRP
     SMLQHLLRRL VFDVPILNEF AKMPLKLLTN HYERCWKYYC LPTGWANFGV TSEEELHLTR
     KLFWGIFDSL AHKKYDPELY RMAMPCLCAI AGALPPDYVD ASYSSKAEKK ATVDAEGNFD
     PRPVETLNVI IPEKLDSFIN KFAEYTHEKW AFDKIQNNWS YGENIDEELK THPMLRPYKT
     FSEKDKEIYR WPIKESLKAM IAWEWTIEKA REGEEEKTEK KKTRKISQSA QTYDPREGYN
     PQPPDLSAVT LSRELQAMAE QLAENYHNTW GRKKKQELEA KGEGAHAGGT KEERRVEKGR
     ARGTEETVGP ASGLILLSTS PCRGLKDMEL DSSSIEKRFA FGFLQQLLRW MDISQEFIAH
     LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFTNHCLY FLSTPAKVLG SGGHASNKEK
     EMITSLFCKL AALVRHRVSL FGTDASAVVN CLHILARSLD ARTVMKSGPE IVKAGLRSFF
     ESASEDIEKM VENLRLGKVS QARTQVKGVG QNLTYTTVAL LPVLTTLFQH IAQHQFGDDV
     ILDDVQVSCY RTLCSIYSLG TTKNTYVEKL RPALGECLAR LAAAMPVAFL EPQLNEYNAC
     SVYTTKSPRE RAILGLPNSV EEMCPDIPVL ERLMADIGGL AESGARYTEM PHVIEITLPM
     LCSYLPRWWE RGPEAPPPAL PAGAPPPCTA VTSDHLNSLL GNILRIIVNN LGIDEASWMK
     RLAVFAQPIV SRARPELLQS HFIPTIGRLR KRAGKVVSEE EQLRLEAKAE AQEGELLVRD
     EFSVLCRDLY ALYPLLIRYV DNNRAQWLTE PNPSAEELFR MVGEIFIYWS KSHNFKREEQ
     NFVVQNEINN MSFLTADNKS KMAKAGDIQS GGSDQERTKK KRRGDRYSVQ TSLIVATLKK
     MLPIGLNMCA PTDQDLITLA KTRYALKDTD EEVREFLHNN LHLQGKVEGS PSLRWQMALY
     RGVPGREEDA DDPEKIVRRV QEVSAVLYYL DQTEHPYKSK KAVWHKLLSK QRRRAVVACF
     RMTPLYNLPT HRACNMFLES YKAAWIVTED HSFEDRMIDD LSTSRGRPST SRGIEMPAPD
     DPLHQLVLHF SRTALTEKSK LDEDYLYMAY ADIMAKSCHL EEGGENGEAE EEVEVSFEEK
     EMEKQRLLYQ QARLHTRGAA EMVLQMISAC KGETGAMVSS TLKLGISILN GGNAEVQQKM
     LDYLKDKKEV GFFQSIQALM QTCSVLDLNA FERQNKAEGL GMVNEDGTVI NRQNGEKVMA
     DDEFTQDLFR FLQLLCEGHN NDFQNYLRTQ TGNTTTINII ICTVDYLLRL QESISDFYWY
     YSGKDVIEEQ GKRNFSKAMS VAKQVFNSLT EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF
     AHMMMKLAQD SSQIELLKEL LDLQKDMVVM LLSLLEGNVV NGMIARQMVD MLVESSSNVE
     MILKFFDMFL KLKDIVGSEA FQDYVTDPRG LISKKDFQKA MDSQKQFSGP EIQFLLSCSE
     ADENEMINCE EFANRFQEPA RDIGFNVAVL LTNLSEHVPH DPRLHNFLEL AESILEYFRP
     YLGRIEIMGA SRRIERIYFE ISETNRAQWE MPQVKESKRQ FIFDVVNEGG EAEKMELFVS
     FCEDTIFEMQ IAAQISEPEG EPETDEDQGS GAAKTRPKKP RRNPPSGLPS HCGPGRPDPT
     SDEVHGEQPA GPGGDADGEG ASEGAGEAAE GAGDEEEAVH VAVTDGGPFR PEGAGGLGDM
     GDTTPAEPPT PEGSPILKRK LGVDGVEEEL PPEPEPEPEP ELEPEKADAE NGEKEEVPEP
     PPEPPKKQAP PSPPPKKEEA GGEFWGELEV QRVKFLNYLS RNFYTLRFLA LFLAFAINFI
     LLFYKVSDSP PGEDDMEGSA AGDVSGAGSG GGSGWGLGAG EEAEGDEDEN MVYYFLEEST
     GYMEPALRCL SLLHTLVAFL CIIGYNCLKV PLVIFKREKE LARKLEFDGL YITEQPEDDD
     VKGQWDRLVL NTPSFPSNYW DKFVKRKKKL AKRGGSHLPA GCLLTRNALI LHVLPKQSWH
     PTPRAQLTLS SGPYPPECSS CVPAFPLTPG PVCPQSFLYL GWYMVMSLLG HYNNFFFAAH
     LLDIAMGVKT LRTILSSVTH NGKQLVMTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP
     DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLEE HNLANYMFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
//
DBGET integrated database retrieval system