ID G3RSE7_GORGO Unreviewed; 648 AA.
AC G3RSE7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=TNF receptor superfamily member 21 {ECO:0000313|Ensembl:ENSGGOP00000018722.2};
GN Name=TNFRSF21 {ECO:0000313|Ensembl:ENSGGOP00000018722.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018722.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018722.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018722.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018722.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; CABD030044908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RSE7; -.
DR Ensembl; ENSGGOT00000022904.2; ENSGGOP00000018722.2; ENSGGOG00000013477.3.
DR eggNOG; ENOG502QVMX; Eukaryota.
DR GeneTree; ENSGT00940000156212; -.
DR TreeFam; TF331157; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000013477; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08778; Death_TNFRSF21; 1.
DR CDD; cd10583; TNFRSF21; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022330; TNFR_21.
DR InterPro; IPR034037; TNFRSF21_death.
DR InterPro; IPR034034; TNFRSF21_N.
DR PANTHER; PTHR46921; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR PANTHER; PTHR46921:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01971; TNFACTORR21.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..648
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014154909"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 83..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 83..124
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 408..491
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 232..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 84..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 106..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 648 AA; 71392 MW; 3C3574DB56C838EB CRC64;
LAFQSSGITG MSHCARLVFL TNVTWLGFLS TTTAQPEQKA SNLIGTYRHV DRATGQVLTC
DKCPAGTYVS EHCTNTSLRV CSSCPVGTFT RHENGIEKCH DCSQPCPWPM IEKLPCAALT
DRECTCPPGM FQSNATCAPH TVCPVGWGVR KKGTETEDVR CKQCARGTFS DVPSSVMKCK
AYTDCLSQNL VVIKPGTKET DNVCGTLPSF SSSTSPSPGT AIFSRPEHME THEVPSSTYV
PKGMNSTESN SSASVRPKVL SSIQEGTVPD NTSSARGKED VNKTLPNLQV VNHQQGPHHR
HILKLLPSME ATGGEKSSTP IKGPKRGHPR QNLHKHFDIN EHLPWMIVLF LLLVLVVIVV
CSIRKSSRTL KKGPRQDPSA IVEKAGLKKS MTPTQNREKW IYYCNGHGID ILKLVAAQVG
SQWKDIYQFL CNASEREVAA FSNGYTADHE RAYAALQHWT IRGPEASLAQ LISALRQHRR
NDVVEKIRGL MEDTTQLETD KLALPMSPSP LSPSPIPSPN AKLENSALLT VEPSPQDKNK
GFFVDESEPL LRCDSTSSGS SALSRNGSFI TKEKKDTVLR QVRLDPCDLQ PIFDDMLHFL
NPEELRVIEE IPQAEDKLDR LFEIIGVKSQ EASQTLLDSV YSHLPDLL
//
