ID G3RTI1_GORGO Unreviewed; 403 AA.
AC G3RTI1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=RalA binding protein 1 {ECO:0000313|Ensembl:ENSGGOP00000019106.2};
GN Name=RALBP1 {ECO:0000313|Ensembl:ENSGGOP00000019106.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019106.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000019106.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000019106.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000019106.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030107117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030107119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RTI1; -.
DR Ensembl; ENSGGOT00000032802.2; ENSGGOP00000019106.2; ENSGGOG00000023120.2.
DR GeneTree; ENSGT00940000154639; -.
DR Proteomes; UP000001519; Chromosome 18.
DR Bgee; ENSGGOG00000023120; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd04381; RhoGap_RalBP1; 1.
DR Gene3D; 1.20.58.90; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039767; RALBP1.
DR InterPro; IPR049041; RalBP1-like_Ral-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12783; RALA BINDING PROTEIN 1 RALBP1; 1.
DR PANTHER; PTHR12783:SF5; RALA-BINDING PROTEIN 1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF20924; RLIP76_Ral-bd; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1..179
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 348..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 47066 MW; 1D56C149C01E63D9 CRC64;
MMYDGIRLPA VFRECIDYVE KYGMKCEGIY RVSGIKSKVD ELKAAYDREE STNLEDYEPN
TVASLLKQYL RDLPENLLTK ELMPRFEEAC GRTTETEKVQ EFQRLLKELP ECNYLLISWL
IVHMDHVIAK ELETKMNIQN ISIVLSPTVQ ISNRVLYVFF THVQELFGNV VLKQVMKPLR
WSNMATMPTL PETQAGIKEE IRRQEFLLNC LHRDLQGGIK DLSKEERLWE VQRILTALKR
KLREAKRQEC ETKIAQEIAS LSKEDVSKEE MNENEEVINI LLAQENEILT EQEELLAMEQ
FLRRQIASEK EEIERLRNNH LNQAIHEERE AIIELRVQLR LLQMQRAKAE QQAQEDEEPE
WRGGAVQPPR DGVLEPKAAK EQPKAGKEPA KPSPSRDRKE TSI
//
