GenomeNet

Database: UniProt
Entry: G3RTX5_GORGO
LinkDB: G3RTX5_GORGO
Original site: G3RTX5_GORGO 
ID   G3RTX5_GORGO            Unreviewed;       689 AA.
AC   G3RTX5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   25-APR-2018, entry version 35.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSGGOP00000019252};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019252, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000019252, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000019252}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CABD030037818; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9593.ENSGGOP00000019252; -.
DR   Ensembl; ENSGGOT00000024301; ENSGGOP00000019252; ENSGGOG00000010819.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3RTX5; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001519; Chromosome 5.
DR   Bgee; ENSGGOG00000010819; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    362    386       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    407    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    500    519       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    593    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    622    645       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   689 AA;  79044 MW;  84859875CF62F42F CRC64;
     LNPDVNVFQR KFVNEVRRCE EMDRKLRFVE KEIRKANIPI MDTGENPEVP FPRDMIDLEA
     NFEKIENELK EINTNQEALK RNFLELTELK FILRKTQQFF DEMADPDLLE ESSSLLEPSE
     MGRGAPLRLG FVAGVINRER IPTFERMLWR VCRGNVFLRQ AEIENPLEDP VTGDYVHKSV
     FIIFFQGDQL KNRVKKICEG FRASLYPCPE TPQERKEMAS GVNTRIDDLQ MVLNQTEDHR
     QRVLQAAAKN IRVWFIKVRK MKAIYHTLNL CNIDVTQKCL IAEVWCPVTD LDSIQFALRR
     GTEHSGSTVP SILNRMQTNQ TPPTYNKTNK FTYGFQNIVD AYGIGTYREI NPAPYTIITF
     PFLFAVMFGD FGHGILMTLF AVWMVLRESR ILSQKNENEM FSTVFSGRYI ILLMGVFSMY
     TGLIYNDCFS KSLNIFGSSW SVRPMFTYNW TEETLRGNPV LQLNPALPGV FGGPYPFGID
     PIWNIATNKL TFLNSFKMKM SVILGIIHML FGVSLSLFNH GTLNFGGIRV GNGPTEEDAE
     IIQHDQLSTH SEDADEPTED EVFDFGDTMV HQAIHTIEYC LGCISNTASY LRLWALSLAH
     AQLSEVLWTM VIHIGLSVKS LAGGLVLFFF FTAFATLTVA ILLIMEGLSA FLHALRLHWV
     EFQNKFYSGT GFKFLPFSFE HIREGKFEE
//
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