ID G3RW92_GORGO Unreviewed; 1701 AA.
AC G3RW92;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=TIAM Rac1 associated GEF 2 {ECO:0000313|Ensembl:ENSGGOP00000020075.2};
GN Name=TIAM2 {ECO:0000313|Ensembl:ENSGGOP00000020075.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000020075.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000020075.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000020075.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000020075.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030048584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030048585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018884934.1; XM_019029389.1.
DR Ensembl; ENSGGOT00000025450.2; ENSGGOP00000020075.2; ENSGGOG00000012161.3.
DR GeneTree; ENSGT00940000157012; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000012161; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProt.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF5; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR TIAM2; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 506..620
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 810..881
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 890..976
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1099..1293
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1500..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1568..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1592..1607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1701 AA; 190234 MW; B8ED3D0D1823208F CRC64;
MGNSDSQYTL QGSKNHSNTI TGAKQIPCSL KIRGIHTKEE KSLHGWGHGS SGAGYKSRSL
ARSCLSHFKS NQPYASRLGG PTCKVSRGVA YSTHRTNAPG KDFQGISAAF STENGFHSVG
HEPADNHVTS RDCNGHLLNC YGRNESIAST PLGEDRKSPR VLIKTLGKLD GCLRVEFHNG
GNPSKVPAED CSEPVQLLRY SPTLASETSP VPEARRESSA DSLPSHRPSP TDSRLRSSKG
SSLSSESSWY DSPWGNAGEL SEAEGSFLAP GMPDPSLHAS FPPGDAKKPF NQSSSLSSLR
ELYKDANLGS LSPSGIRLSD EYMGTHASLS NRVSFASDID VPSRVAHRDP VQYSSFTLPC
RKPKALVEDT AKKDSLKARM RRISDWTGSL SRKKRKLQEP RSKEGSDYFD SRSDGLNTDV
QGSSQASAFL WSGGSAQILS QRSESTHAIG SDPLRQNIYE NFMRELEMSR TNTENIETST
ETAESSSESL SSLEQLDLLF EKEQGVVRKA GWLFFKPLVT VQKERKLELV ARRKWKQYWV
TLKGCTLLFY ETYGKNSMDQ SSAPRCALFA EDSIVQSVPE HPKKENVFCL SNSFGDVYLF
QATSQTDLEN WVTAVHSACA SLFAKKHGKE DTLRLLKNQT KNLLQKIDMD SKMKKMAELQ
LSVVSDPKNR KAIENQIQQW EQNLEKFHMD LFRMRCYLAS LQGGELPNPK SLLAAASRPS
KLALGRLGIL SVSSFHALVC SRDDSALRKR TLSLTQRGRN KKGIFSSLKG LDTLARKGKE
KRPSITQVDE LLHIYGSTVD SVPRDNAWEI QTYVYFQDNH GVTVGIKPEH RVEDILTLAC
KMRQLEPSHY GLQLRKLVDD NVEYCIPAPY EYMQEQVYDE IEVFPLNVYD VQLTKTGSVC
DFGFAVTAQV DERQHLSRIF ISDVLPDGLA YGEGLRKGNE IMTLNGEAVS DLDLKQMEAL
FSEKSVGLTL IARPPDTKAT LCTSWSDSDL FSRDQKSLLP PPNQSQLLEE FLDNFKKNTA
NDFSNVPDIT TGLKRSQTDG TLDQVSHREK MEQTFRSAEQ ITALCRSFND SQANGMEGPR
ESQDPPPRPL ARHLSDADRL RKVIQELVDT EKSYVKDLSC LFELYLEPLQ NETFLTQDEM
ESLFGSLPEM LEFQKVFLET LEDGISASSD FNTLETPSQF RKLLFSLGGS FLYYADHFKL
YSGFCANHIK VQKVLERAKT DKAFKAFLDA RNPTKQHSST LESYLIKPVQ RVLKYPLLLK
ELVSLTDQES EEHYHLTEAL KAMEKVASHI NEMQKIYEDY GTVFDQLVAE QSGTEKEVTE
LSMGELLMHS TVSWLNPFLS LGKARKDLEL TVFVFKRAVI LVYKENCKLK KKLPSNSRPA
HNSTDLDPFK FRWLIPISAL QVRLGNPAGT ENNSIWELIH TKSEIEGRPE TIFQLCCSDS
ESKTNIVKVI RSILRENFRR HIKCELPLEK TCKDRLVPLK NRVPVSAKLA SSRSLKVLKN
SSSNEWTGET GKGTLLDSDE GSLSSGTQSS GCPTAEGRQD SKSTSPGKYP HPGLADFADN
LIKESDILSD EDDDHHRTVK QGSPTKDIEI QFQRLRISED PDVHPEAEQQ PGPESGEGQK
GGEQPKLVRG HFCPIKRKAN STKRDRGTLL KAQIRHQSLD SQSENATIDL NSVLEREFSV
QSLTSVVSEE CFYETESHGK S
//
