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Database: UniProt
Entry: G3RWY1_GORGO
LinkDB: G3RWY1_GORGO
Original site: G3RWY1_GORGO 
ID   G3RWY1_GORGO            Unreviewed;      4566 AA.
AC   G3RWY1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 64.
DE   SubName: Full=Apolipoprotein B {ECO:0000313|Ensembl:ENSGGOP00000020316.2};
GN   Name=APOB {ECO:0000313|Ensembl:ENSGGOP00000020316.2};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000020316.2, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000020316.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000020316.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000020316.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lipid
CC       droplet {ECO:0000256|ARBA:ARBA00004502}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00557}.
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DR   EMBL; CABD030014007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9593.ENSGGOP00000020316; -.
DR   Ensembl; ENSGGOT00000028773.2; ENSGGOP00000020316.2; ENSGGOG00000005179.3.
DR   eggNOG; KOG4338; Eukaryota.
DR   GeneTree; ENSGT00590000083139; -.
DR   HOGENOM; CLU_000127_0_0_1; -.
DR   InParanoid; G3RWY1; -.
DR   OMA; FTCAYEN; -.
DR   TreeFam; TF331316; -.
DR   Proteomes; UP000001519; Chromosome 2A.
DR   Bgee; ENSGGOG00000005179; Expressed in liver and 2 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:Ensembl.
DR   GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl.
DR   GO; GO:0034362; C:low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0034359; C:mature chylomicron; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR   GO; GO:0120020; F:cholesterol transfer activity; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR   GO; GO:0035473; F:lipase binding; IEA:Ensembl.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IBA:GO_Central.
DR   GO; GO:0005543; F:phospholipid binding; IEA:Ensembl.
DR   GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR   GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0042632; P:cholesterol homeostasis; IBA:GO_Central.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR   GO; GO:0030301; P:cholesterol transport; IBA:GO_Central.
DR   GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR   GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0042158; P:lipoprotein biosynthetic process; IEA:Ensembl.
DR   GO; GO:0042159; P:lipoprotein catabolic process; IEA:Ensembl.
DR   GO; GO:0042953; P:lipoprotein transport; IBA:GO_Central.
DR   GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Ensembl.
DR   GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR   GO; GO:0010886; P:positive regulation of cholesterol storage; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0045540; P:regulation of cholesterol biosynthetic process; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   GO; GO:0019433; P:triglyceride catabolic process; IEA:Ensembl.
DR   GO; GO:0006642; P:triglyceride mobilization; IBA:GO_Central.
DR   Gene3D; 2.20.80.10; Lipovitellin-phosvitin complex, chain A, domain 4; 1.
DR   Gene3D; 2.20.50.20; Lipovitellin. Chain A, domain 3; 1.
DR   Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR   InterPro; IPR022176; ApoB100_C.
DR   InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR   InterPro; IPR009454; Lipid_transpt_open_b-sht.
DR   InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR   InterPro; IPR015816; Vitellinogen_b-sht_N.
DR   InterPro; IPR015255; Vitellinogen_open_b-sht.
DR   InterPro; IPR015817; Vitellinogen_open_b-sht_sub1.
DR   InterPro; IPR001747; Vitellogenin_N.
DR   PANTHER; PTHR13769; APOLIPOPROTEIN B; 1.
DR   PANTHER; PTHR13769:SF1; APOLIPOPROTEIN B-100; 1.
DR   Pfam; PF12491; ApoB100_C; 1.
DR   Pfam; PF06448; DUF1081; 1.
DR   Pfam; PF09172; Vit_open_b-sht; 1.
DR   Pfam; PF01347; Vitellogenin_N; 1.
DR   SMART; SM01169; DUF1943; 1.
DR   SMART; SM00638; LPD_N; 1.
DR   SUPFAM; SSF48431; Lipovitellin-phosvitin complex, superhelical domain; 1.
DR   PROSITE; PS51211; VITELLOGENIN; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00557};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..4566
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014125872"
FT   DOMAIN          49..675
FT                   /note="Vitellogenin"
FT                   /evidence="ECO:0000259|PROSITE:PS51211"
FT   COILED          4363..4390
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   DISULFID        189..215
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00557"
SQ   SEQUENCE   4566 AA;  516048 MW;  B9E5F139CDF03AF8 CRC64;
     MGPPRSALLA LLALPALLLL LAGARAGECS YFCYVADVFL PTLGDATRFK HLRKYTYNYE
     AESSSGVPGT ADSRSATRIN CKVELEVPQP CSFILKTSQC TLKEVYGFNP EGKALLKKTK
     NSEEFAAAMS RYELKLAIPE GKRVFLYPEK DEPTYILNIK RGIISALLVP PETEEAEQVL
     FLDTVYGNCS THFTVKTRKS NVATEISTER DLGQCDRFKP IRTGISPLAL IKGMTRPLST
     LISSSQSCQY TLDAKRKHVA EAICKEQHLF LPFSYKNKYG MVAQVTQTLK LEDTPKINSR
     FFGEGTKKMG LAFESTKSTS PPKQAEAVLK TLQELKKLTI SEQNTQRANL FNKLVTELRG
     LSDEAVTSLL PQLIEVSSPI TLQALVQCGQ PQCSTHILQW LKRVHANPLL IDVVTYLVAL
     IPEPSAQQLR EIFNMARDQR SRATLYALSH AVNNYHKTNP TGTQELLDIA NYLMEQIQDD
     CTGDEDYTYL ILRVIGNMGQ TMEQLTPELK SSILKCVQST KPSLMIQKAA IQALRKMEPK
     DKDQEVLLQT FLGDASPGDK RLAAYLMLMR SPSQADINKI VQLLPWEQNE QVKNFVASHI
     ANILNSEELD IQDLKKLVKE ALKESQLPTV MDFRKFSRNY QLYKSVSLPS LDPASAKIEG
     NLIFDPNNYL PKESMLKTTL TAFGFASADL IEIGLEGKGF EPTLEALFGK QGFFPDSVNK
     ALYWVNGQVP DGVSKVLVDH FGYTKDDKRE QDMVNGMMLS VEKLIKDLKS KEVPEARAYL
     RILGEELGFA RLHDLQLLGK LLLMGARTLQ GIPQMIGEVI RKGSKNDFFL HYIFMENAFE
     LPTGAGLQLQ ISSSGVIAPG AKAGVKLEVA NMQAELVAKP SVSVEFVTNM GIIIPDFARS
     GVQMNTNFFH ESGLEAHVAL KAGQLKFIIP SPKRPVKLLS GGNTLHLVST TKTEVIPPLI
     ENRQSWSVCK QVFPGLNYCT SGAYSNASST DSASYYPLTG DSRLELELRP TGEIEQYSVS
     ATYELQREDR ALVDTLKFVT QAEGAKQTEA TMTFKYNRQS MTLSSEVQIP DFDVDLGTIL
     RVNDESTEGK TSYRLTLDIQ NKKITEVALM GHLSCDTKEE RKIKGVISIP RLQAEARSEI
     LAHWSPAKLL LQMDSSATAY GSTVSKRVAW HYDEEKIELE WNTGTNVDTK KMTSNFPVDL
     SDYPKSLHMY ANRLLDHSVP QTDMTFRHVG SKLIVAMSSW LQKASGSLPY TQTLQDHLNS
     LKEFNLQNMG LPDFHIPENL FLKSDGRVKY TLNKNSLKIE IPLPFGGKSS RDLKMLETVR
     TPALHFKSVG FHLPSREFQV PTFTIPKLYQ LQVPLLGVLD LSTNVYSNLY NWSASYSGGN
     TSTDHFSLRA RYHMKADSVV DLLSYNVQGS GETTYDHKNT FTLSCDGSLR HKFLDSNIKF
     SHVEKLGNNP VSKGLLIFDA SSSWGPQMSA SVHLDSKKKQ HLFVKEVKID GQFRVSSFYA
     KGTYGLSCQR DPNTGRLNGE SNLRFNSSYL QGTNQITGRY EDGTLSLTST SDLQSGIIKN
     TASLKYENYE LTLKSDTNGK YKNFATSNKM DMTFSKQNAL LRSEYQADYE SLRFFSLLSG
     SLNSHGLELN ADILGTDKIN SGAHKATLRI GQDGISTSAT TNLKYSLLVL ENELNAELGL
     SGASMKLTTN GRFKEHNAKF SLDGKAALTE LSLGSAYQAM ILGVDSKNIF NFKISQEGLK
     LSNDMMGSYA EMKFDHTNNL NIAGLTLDFS SKLDNIYSSD KFYKQTVNLQ LQPYSLVTTL
     NSDLKYNALD LTNNGKLRLE PLKLHVAGNL KGAYQNNEIK HIYAISSAAL SASYKADTVA
     KVQGVEFSHR LNTDIAGLAS AIDMSTNYNS DSLHFSNVFR SVMAPFTMTI DAHTNGNGKL
     ALWGEHTGQL YSKFLLKAEP LAFTFSHDYK GSTNHHLVSR KSISAALEHK VSALLTPAEQ
     TGTWKLKTQF NNNEYSQDLD AYNTKDKIGV ELTGRTLADL TLLDSPIKVP LLLSEPINII
     DALEMRDAIE KPQEFTIVAF VKYDKNQDVH SINLPFFETL QEYFERNRQT IIVVLENVQR
     DLKHINIDQF VRKYRAALGK LPQQANDYLN SFNWERQVSR AKEKLTALTK KYRITENDIQ
     IALDDAKINF NEKLSQLQTY MIQFDQYIKD NYDLHDLKIA IANIIDEIIE KLKSLDEHYH
     IRVNLVKTIH DLHLFIENIH FNKSGSSTAS WIQNVDTKYQ IRIQIQEKLQ QLKRHIQNID
     IQHLAGKLKQ HVEAIDVTVL LDQSGTTISF ERINDVLEHV KHFVINLIGD FEVAEKINAF
     RAKVHELIER YEVDQQIQVL MDKLVELAHQ YKLKETIQKL SNVLQKVKIK DYFEKLVGFI
     DDAVKKLNEL SFKTFIEDVN KFLDMLIKKL KSFDYHQFVD ETNDKIREVT QRLNGEIQAL
     ELPQKAEALK LFLEETKATV EVYLESLQDT KITLIINWLQ EALSSASLAH MKAKFRETLE
     DTRDRMYQMD IQQELQRYLS LVGQVYSTLV TYISDWWTLA AKNLTDFAEQ YSIQDWAKRV
     KALVEQGFTV PEIKTILGTM PAFEVSLQAL QKATFQTPDF IVPLTDLRIP SVQIHFKDLK
     NIKIPSRFST PEFTILNTFH IPSFTIDFVE MKVKIIRTID QMLNSELQWP VPDVYLRDLK
     VEDIPLARIT LPDFHLPEIA IPEFIIPTLN LNDFQVPDLH IPEFQLPHIS HTIEVPTFGK
     LYSILKIQSP LFTLDANADI RNGTTSANEA GIAASITAKG ESKLEVLNFD FQANAQLSNP
     KINPLALKES VKFSSKYLRT EHGSEMLFFG NAIEGKSSTV ASLHTEKNTL ELSNGVIVKI
     NNQLTLDSNT KYFHKLNIPK LDFSSQADLR NEIKTLLEAG HIAWTSSGKG SWKWACPRFS
     DEGTHESQIS FTIEGPLTSF GLSNKINSKH LRVSQNLVYE SGSLNFSKLE IQSQVDSQHV
     GHSVLTAKGT ALFGEGKAEF TGRHDAHLNG KVIGTLKNSL FFSAQPFEIT ASTNNEGNLK
     VSFPLRLTGK IDFLNNYALF LSPSAQQASW QVSARFNQYK YNQNFSAGNN ENIMEAHVGI
     NGEANLDFLN IPLTIPEMHL PYTIITTPPL KDFSLWEKTG LKEFLKTTKQ SFDLSVKAQY
     KKNKHRHSIT NPLAVLYEFT SQSIKPFDRH FEKNRNNALD FVTKSYNETK IKFDKYKAEK
     SHDELPRTFQ IPGYTVPVVN VEVSPFTIEM SAFGYVFPKA VSMPSFTILG SDIRVPSYTL
     ILPSLELPVL HVPRNLKLSL PDFKELYTIS HIFIPAMGNI TYDFSFKSSV ITLNTNAELF
     NQSDIVAHLL SSSSSVIDAL QYKLEGTTRL TRKRGLKLAT ALSLSNKFVE GSHNSTVSLT
     TKYMEASVAT TAKAQIPILR MNFKQELNGN TKAKPTVSSS MEFKYDFNSS MLYSTAKGAV
     DHKLSLESLT SYFSIESSTK GDVKGSVLSR EYSGTIASEA NTYLNSKSTR SSVKLQGTSK
     IDDIWNLEVK ENFAGEATLQ RIYSLWEHST KNHLQLEGLF FTNGEHTSKA TLELSPWEMS
     ALVQVHASQP SSFHDFPHLG QEVALNANTK NQKIRWKNEV RIHSGSFQSH VELSNDQEKA
     HLDIAGSLEG HLRFLKNIIL PVYDKSLWDF LKLDVTTSIG RRQRLRVSTA FVYTKNPNGY
     SFSIPVKVLA DKFIIPGLKL NDLNSVLVMP TFHVPFTDLQ VPSYKLDFRE IKIYKKLRTS
     SFALNLPTLP EVKFPEVDVL TKYSQSEDSL IPFFEITVPE SQLTVSQFTL PKSVSDGIAA
     LDLNAVANKI ADFELPTIIM PEQTIEIPSI KFSVPAGIVI PSFQALTAHF EVDSPLYNAT
     WSASLKNKAD CVETVLDSTC SSTVQFLEYE LNVVGTHKIE DGMLASKTKG TFAHRDFSAE
     YEEDGKYEGL QEWEGKAYLN IKSPAFTDLH LRYQKDKKGI STSAASPAIG TVGMDMDEDD
     DFSKWNFYYS PQSSPDKKLT IFKTELRVRE SDEEIQIKVN WEEEAASGLL TSLKDNVPKA
     TGALYDYVNK YHWEHTGLTL REASSKLRRN LQNNAEWVYQ GAIRQIDDID VRFQKAASGT
     TGTYQEWKDK AQNLYQELLT QEGQANFQGL KDKVFDGLVR VTQEFHMKVK HLIDSLIDFL
     NFPRFQFPGK PGIYTREELC TMFIREVGTV LSQVYSKVHN GSEILFSYFQ DLVITLPFEL
     RKHKLIEVIS MYRELLKDLS KEAQEVFKAI QSLKTTEVLR NLQELLQFIF QLIEDNIKQL
     KEMKFTYLIN YIQDEINTIF NDYIPYVFKL LKENLCLNLH KFNEFIQNEL QEASQELQQI
     HQYIMALREE YFDPSIVGWT VKYYELEEKI VSLIKNLLVS LKDFHSEYIV SASDFTSQLS
     SQVEQFLHRN ILEYLSILTD PDGKGKEKIA ELSATAQEII KSQAIATKKI ISDYHQQFRY
     KLQDFSDQLS DYYEKFIAES KRLIDLSIQN YHTFLIYIKE LLKKLQSTTV MNPYMKLAPG
     ELTIIL
//
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