ID G3RXC1_GORGO Unreviewed; 598 AA.
AC G3RXC1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000020457.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000020457.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000020457.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000020457.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR EMBL; CABD030083632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030083633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030083634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RXC1; -.
DR STRING; 9593.ENSGGOP00000020457; -.
DR Ensembl; ENSGGOT00000033616.2; ENSGGOP00000020457.2; ENSGGOG00000037614.1.
DR eggNOG; ENOG502QV5K; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_017264_0_1_1; -.
DR InParanoid; G3RXC1; -.
DR OMA; CAHANEN; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000037614; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0042470; C:melanosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0032438; P:melanosome organization; IBA:GO_Central.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..229
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 240..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 63445 MW; 4BA83024A207713D CRC64;
LYKIHFKKIS QVWWYAPVVP ATPGAEEGGS LEPRRLRLQL AMITPLYSRS QVWGGQPVYP
QETDDACIFP DGGPCPSGPW SQKRSFVYVW KTWGQYWQVL GGPVSGLSIG TGRAMLGTHT
MEVTVYHRRG SRSYVPLAHS SSAFTITDQV PFSVSVSQLR ALDGGNKHFL RNQPLTFALQ
LHDPSGYLAE ADLSYTWDFG DSSGTLISRA LVVTHTYLEP GPVTAQVVLQ AAIPLTSCGS
SPVPGTTDGH RPTAEAPNTT AGQVPTTEVV GTTPGQAPTA EPSGTTSVQV PTTEVISTAP
VQMPTAESTG TTPEKVPVSE VMGTTLAEMS TPEATGMTPA EVSIVVPSGT TAAQVTTTEW
VETTARELPI PEPEGPDASS IMSTESITGS LGPLLDGTAT LRLVKRQVPL DCVLYRYGSF
SITLDIVQGI ESAEILQAVP SSEGDAFELT VSCQGGLPKE ACMEISSPGC QPPAQQLCQP
VLPSPACQLV LHQILKGGSG TYCLNVSLAD ANSLAVVSTQ LIMPGQEAGL GQAPLIVGIL
LVLTAVVLAS LIYRRRLMKQ DLSIPQLPHS SSHWLRLPRI FCSCPIGENS PLLSGQQV
//
