ID G3RXH9_GORGO Unreviewed; 589 AA.
AC G3RXH9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Ankyrin repeat and sterile alpha motif domain containing 1A {ECO:0000313|Ensembl:ENSGGOP00000020515.2};
GN Name=ANKS1A {ECO:0000313|Ensembl:ENSGGOP00000020515.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000020515.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000020515.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000020515.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000020515.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030044426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RXH9; -.
DR Ensembl; ENSGGOT00000022119.2; ENSGGOP00000020515.2; ENSGGOG00000007973.3.
DR GeneTree; ENSGT00940000155806; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000007973; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd01274; PTB_Anks; 1.
DR CDD; cd09499; SAM_AIDA1AB-like_repeat1; 1.
DR CDD; cd09500; SAM_AIDA1AB-like_repeat2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041880; SAM_ANKS1_repeat1.
DR InterPro; IPR041882; SAM_ANKS1_repeat2.
DR PANTHER; PTHR24174:SF4; ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 1A; 1.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00454; SAM; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 25..88
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 96..155
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 295..382
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 182..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65494 MW; 59A987488DDB6B37 CRC64;
MSSIGEGIDF SQERQKISGS RTLEQSVGEW LESIGLQQYE SKLLLNGFDD VRFLGSNVME
EQDLRDIGIS DPQHRRKLLQ AARSLPKVKA LGYDGNSPPS VPSWLDSLGL QDYVHSFLSS
GYSSIDTVKN LWELELVNVL KVQLLGHRKR IIASLADRPY EEPPQKPPRF SQLRCQDLLS
QTSSPLSQND SCTGRSADLL LPPGDTGRRR HDSLHDSAAP SRAERFRIQE EHREAKLTLR
PPSLAAPYAP VQSWQHQPEK LIFESCGYEA NVSSLTGLRG TDRKSTEHMK KIPTIILSIT
YKGVKFIDAS NKNVIAEHEI RNISCAAQDP EDLCTFAYIT KDLQTSHHYC HVFSTVDVNL
TYEIILTLGQ AFEVAYQLAL QAQKSRATGA SAAEMIETKS SKPVPKPRVG VRKSTVPLPP
DSRCCYCHTC TTHRPSYLPL PSVSPGVKLE PPDMDQDAQS HASVSWVVDP KPDSKRSLST
NHTRLELVCC SQPENELVST ISGDKPKSFL EPLLFVMPTT AYNHNCPEWR SQKDGGCSTS
ECPHHLCLEK PGVLSLEMRE GRLSGLENRT GINLIQVSHR PNCPSLNSG
//
