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Database: UniProt
Entry: G3S178_GORGO
LinkDB: G3S178_GORGO
Original site: G3S178_GORGO 
ID   G3S178_GORGO            Unreviewed;      1980 AA.
AC   G3S178;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 41.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1F {ECO:0000313|Ensembl:ENSGGOP00000021823};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000021823, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000021823, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000021823}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000021823}.
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DR   STRING; 9593.ENSGGOP00000021823; -.
DR   Ensembl; ENSGGOT00000034163; ENSGGOP00000021823; ENSGGOG00000000907.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G3S178; -.
DR   OMA; LNQTECR; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001519; Chromosome X.
DR   Bgee; ENSGGOG00000000907; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF234; PTHR10037:SF234; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     96    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    237    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    531    549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    564    582       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    660    679       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    729    751       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    868    886       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    906    926       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    938    964       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1013       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1109   1136       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1187   1208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1220   1239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1322   1340       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1437       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1571   1605       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   1980 AA;  220679 MW;  77BE66731CDDD16F CRC64;
     MSESEGGKDT TPEPSPANGA GPGPEWGLCP GPPAVEGESS GASGLGTPKR RNQHSKHKTV
     AVASAQRSPR ALFCLTLANP LRRSCISIVE WKPFDILILL TIFANCVALG VYIPFPEDDS
     NTANHNLEQV EYVFLVIFTV ETVLKIVAYG LVLHPSAYIR NGWNLLDFII VVVGLFSVLL
     EQGPGRPGDA PHTGGKPGGF DVKALRAFRV LRPLRLVSGV PSLHIVLNSI MKALVPLLHI
     ALLVLFVIII YAIIGLELFL GRMHKTCYFL GSDMEAEEDP SPCASSGSGR ACTLNQTECR
     GRWPGPNGGI TNFDNFFFAM LTVFQCITME GWTDVLYWMQ DAMGYELPWV YFVSLVIFGS
     FFVLNLVLGV LSGWEFSKER EKAKARGDFQ KQREKQQMEE DLRGYLDWIT QAEELDMEDP
     SADGNLGSMA EEGRAGHRPQ LAELTNRRRG RLRWFSHSTR STHSTSSHAS LPASDTGSMT
     ETQGDEDEEE GALASCTRCL NKIMKTRVCR RLRRANRVLR ARCRRAVKSN ACYWAVLLLV
     FLNTLTIASE HHGQPVWLTQ IQEYANKVLL CLFTVEMLLK LYGLGPSAYV SSFFNRFDCF
     VVCGGILETT LVEVGAMQPL GISVLRCVRL LRIFKVTRHW ASLSNLVASL LNSMKSIASL
     LLLLFLFIII FSLLGMQLFG GKFNFDQTHT KRSTFDTFPQ ALLTVFQILT GEDWNVVMYD
     GIMAYGGPFF PGMLVCIYFI ILFICGNYIL LNVFLAIAVD NLASGDAGTA KDKGGENSGD
     QNFPQVPGVE KEEEEGARRE GAGKLGMWSA TFGNIEVKEG KGAGGVELLQ EVVPKEKVVP
     IPEGSAFFCL SQTNPLRKGC HTLIHHHVFT NLILVFIILS SVSLAAEDPI RAHSFRNHIL
     GYFDYAFTSI FTVEILLKMT VFGAFLHRGS FCRSWFNMLD LLVVSVSLIS FGIHSSAISV
     VKILRVLRVL RPLRAINRAK GLKHVVQCVF VAIRTIGNIM IVTTLLQFMF ACIGVQLFKG
     KFYTCTDEAK HTPQECKGSF LVYPDGDVSR PLVRERLWVN SDFNFDNVLS AMMALFTVST
     FEGWPALLYK AIDAYAEDHG PIYNYRVEIS VFFIVYIIII AFFMMNIFVG FVIITFRAQG
     EQEYQNCELD KNQRQCVEYA LKAQPLRRYI PKNPHQYRVW ATVNSAAFEY LMFLLILLNT
     VALAMQHYEQ TAPFNYAMDI LNMVFTGLFT IEMVLKIIAF KPKHYFTDAW NTFDALIVVG
     SIVDIAVTEV NNGGHLGESS EDSSRISITF FRLFRVMRLV KLLSKGEGIR TLLWTFIKSF
     QALPYVALLI AMIFFIYAVI GMQMFGKVAL QDGTQINRNN NFQTFPQAVL LLFRCATGEA
     WQEIMLASLP GNRCDPESDF GPGEEFTCGS NFAIAYFISF FMLCAFLIIN LFVAVIMDNF
     DYLTRDWSIL GPHHLDEFKR IWSEYDPGAK GRIKHLDVVA LLRRIQPPLG FGKLCPHRVA
     CKRLVAMNMP LNSDGTVTFN ATLFALVRTS LKIKTEGNLE QANQELRIVI KKIWKRMKQK
     LLDEVIPPPD EEEVTVGKFY ATFLIQDYFR KFRRRKEKGL LGNEAAPSTS SALQAGLRSL
     QDLGPEMRQA LTCDLETNKE LDCKILRQSP ESSPREAPSA IEKYLATVVS QPSTRQGSRI
     SVSLPVGDRL PDSLSFGPSD DDRGTPTSSQ PSVPQAGSNT HRRGSGALIF TIPEEGNSQP
     KGTKGQNKQD EDKEVPDRLS YLDEQAGTPP CSVLLPPHRA QRYMDGHLVP RRRLLPPTPA
     GRKPSFTIQC LQRQGSCEDL PIPGTYHRGR NSGPNRAQGS WATPPQRGRL LYAPLLLVEE
     GAAGEGYLGR SSGPLRTFTC LHLPGTHSDP SHGKRGSADS LVEAVLISEG LGLFARDPRF
     VALAKQEIAD ACRLTLDEMD NAASDLLAQG TSSLYSDEES ILSRFDEEDL GDEMACVHNL
//
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