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Database: UniProt
Entry: G3S549_GORGO
LinkDB: G3S549_GORGO
Original site: G3S549_GORGO 
ID   G3S549_GORGO            Unreviewed;      2358 AA.
AC   G3S549;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 33.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSGGOP00000023204};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000023204, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000023204, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000023204}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000023204}.
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DR   Ensembl; ENSGGOT00000028080; ENSGGOP00000023204; ENSGGOG00000003386.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000001519; Chromosome 5.
DR   Bgee; ENSGGOG00000003386; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF256; PTHR10037:SF256; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    116    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    207    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    362    387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    725    743       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    776       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    846    865       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    922    945       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1258   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1296   1317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1329   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1393   1415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1495   1518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1593   1614       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1626   1649       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1727   1746       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1810   1832       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       73    398       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      724    950       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1256   1528       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1592   1842       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1527   1554       {ECO:0000256|SAM:Coils}.
FT   COILED     1831   1855       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2358 AA;  260441 MW;  FA4E0372F8EA3D53 CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSAEKD PGSADSEAEG LPYPALAPVV FFYLSQDSRP
     RSWCLRTVCN PYTWFERISM LVILLNCVTL GMFRPCEDIA CDSQRCRILH QAFDDFIFAF
     FAVEMVVKMV ALGIFGKKCY LGDTWNRLDF FIVIAGMLEY SLDLQNVSFS AVRTVRVLRP
     LRAINRVPSM RILVTLLLDT LPMLGNVLLL CFFVFFIFGI VGVQLWAGLL RNRCFLPENF
     SLPLSVDLER YYQTENEDES PFICSQPREN GMRSCRSVPT LRGEGGGGPP CGLDYEAYNS
     SSNTTCVNWN QYYTNCSAGE HNPFKGAINF DNIGYAWIAI FQVITLEGWV DIMYFVMDAH
     SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQRESQ LMREQRVRFL SNASTLASFS
     EPGSCYEELL KYLVYILRKA ARRLAQVSRA AGVRVGLLSS PAPLGGQETQ PSSSCSRSHR
     RLSVHHLLGN GTLRAPRASP EIQDRDANGS RRLMLPPPST PALSGAPPGG AESVHSFYHA
     DCHLEPVRCQ APPPRSPSEA SGRTVGSGKV YPTVHTSPPP ETLKEKALVE VAASSGPPTL
     TSLNIPPGPY SSMHKLLETQ STGACQSSCK ISSPCLKADS GACGPESCPY CARAGAGEVE
     LADREMPDSD SEAVYEFTQD AQHSDLRDPH SRRQRSLGPD AEPSSVLAFW RLICDTFRKI
     VDSKYFGRGI MIAILVNTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKLLVYGP
     FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFLP ALQRQLVVLM
     KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT LPDRKNFDSL LWAIVTVFQI
     LTQEDWNKVL YNGMASTSSW AALYFIALMT FGNYVLFNLL VAILVEGFQA EEISKREDAS
     GQLSCIQLPV DSQGGDANKS ESEPDFFSPS LDGDGDRKKC LALVSLGEHP ELRKSLLPPL
     IIHTAATPMS LPKSTSTGLG EALGPASRRT SSSGSAEPGA AHEMKSPPSA RSSPHSPWSA
     ASSWTSRRSS RNSLGRAPSL KRRSPSGERR SLLSGEGQES QDEEESSEEE RASPAGSDHR
     HRGSLEREAK SSFDLPDTLQ VPGLHRTASG RGSASEHQDC NGKSASGRLA RALQPDDPPL
     DGDDADDEGN LSKGERVRAW IRARLPACCL ERDSWSAYIF PPQSRFRLLC HRIITHKMFD
     HVVLVIIFLN CITIAMERPK IDPHSAERIF LTLSNYIFTA VFLAEMTVKV VALGWCFGEQ
     AYLRSSWNVL DGLLVLISVI DILVSMVSDS GTKILGMLRV LRLLRTLRPL RVISRAQGLK
     LVVETLMSSL KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF VCQGEDTRNI TNKSDCAEAS
     YRWVRHKYNF DNLGQALMSL FVLASKDGWV DIMYDGLDAV GVDQQPIMNH NPWMLLYFIS
     FLLIVAFFVL NMFVGVVVEN FHKCRQHQEE EEARRREEKR LRRLEKKRRN LMLDDVIASG
     SSASAASEAQ CKPYYSDYSR FRLLVHHLCT SHYLDLFITG VIGLNVVTMA MEHYQQPQIL
     DEALKICNYI FTVIFVLESV FKLVAFGFRR FFQDRWNQLD LAIVLLSIMG ITLEEIEVNA
     SLPINPTIIR IMRVLRIARV LKLLKMAVGM RALLDTVMQA LPQVGNLGLL FMLLFFIFAA
     LGVELFGDLE CDETHPCEGL GRHATFRNFG MAFLTLFRVS TGDNWNGIMK DTLRDCDQES
     TCYNTVISPI YFVSFVLTAQ FVLVNVVIAV LMKHLEESNK EAKEEAELEA ELELEMKTLS
     PQPHSPLGSP FLWPGVEGPD SPDSPKPGAL HPAAHARSAS HFSLEHPTDR QLFDTISLLI
     QGSLEWELKL MDELAGPGGQ PSAFPSAPSL GGSDPQIPLA EMEALSLTSE IVSEPSCSLA
     LTDDSLPDDM HTLLLSALES NMQPHPTELP GPDLLTVRKS GVSRTHSLPN DSYMCRHGST
     AEGPLGHRGW GLPKAQSGSV LSVHSQPADT SYILQLPKDA PHLLQPHSAP TWGTIPKLPP
     PGRSPLAQRP LRRQAAIRTD SLDVQGLGSR EDLLAEVSGP SPPLARAYSF WGQSSTQAQQ
     HSRSHSKISK HMTPPAPCPG PEPNWGKGPP ETRSSLELDT ELSWISGDLL PPGGQEEPPS
     PRDLKKCYSV EAQSCQRRPT SWLDEQRRHS IAVSCLDSGS QPHLGTDPSN LGGQPLGGPG
     SRPKKKLSPP SITIDPPESQ GPRPPPSPGI CLRRRAPSSD SKDPLASGPP DSMAASPSPK
     KDVLSLSGLS SDPADLDP
//
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