ID G3SCD0_GORGO Unreviewed; 388 AA.
AC G3SCD0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cytochrome P450 family 2 subfamily C member 8 {ECO:0000313|Ensembl:ENSGGOP00000025757.2};
GN Name=CYP2C8 {ECO:0000313|Ensembl:ENSGGOP00000025757.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000025757.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000025757.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000025757.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000025757.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CABD030075474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030075475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030075476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030075477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3SCD0; -.
DR Ensembl; ENSGGOT00000025699.2; ENSGGOP00000025757.2; ENSGGOG00000000522.3.
DR eggNOG; KOG0156; Eukaryota.
DR GeneTree; ENSGT00940000163696; -.
DR HOGENOM; CLU_001570_22_3_1; -.
DR TreeFam; TF352043; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000000522; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20665; CYP2C-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300:SF317; CYTOCHROME P450 2C8; 1.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
SQ SEQUENCE 388 AA; 44316 MW; 25408220FD4DE53E CRC64;
MFLQPIAKGI VSSNGKRWKE IRRFSLTTLR NFGMGKRSIE DRVQEEAHCL VEELRKTKAS
PCDPTFILGC APCNVICSVV FQKRFDYKDQ NFLTLMKRFN ENFRILNSPW IQVCNNFPLL
IDCFPGTHNK VLKNVALTQS YIREKVKEHQ ASLDVNNPRD FIDCFLIKME QEKDNQKSEF
NIENLVGTVA DLFVAGTETT STTLRYGLLL LLKHPEVTAK VQEEIDHVIG RHRSPCMQDR
SHMPYTDAVV HEIQRYSDLV PTGVPHAVTT DTKFRNYLIP KGTTIMALLT SVLHDDKEFP
NPNIFDPGHF LDKNGNFKKS DYFMPFSAGK RICAGEGLAR MELFLFLTTI LQNFNLKSVD
DLKNLNTTAV TKGIVSLPPS YQICFIPV
//
