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Database: UniProt
Entry: G3SCI1_GORGO
LinkDB: G3SCI1_GORGO
Original site: G3SCI1_GORGO 
ID   G3SCI1_GORGO            Unreviewed;      1614 AA.
AC   G3SCI1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   SubName: Full=Sodium voltage-gated channel alpha subunit 9 {ECO:0000313|Ensembl:ENSGGOP00000025809};
GN   Name=SCN9A {ECO:0000313|Ensembl:ENSGGOP00000025809};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000025809, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000025809, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000025809}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGGOP00000025809}.
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DR   STRING; 9593.ENSGGOP00000025809; -.
DR   Ensembl; ENSGGOT00000028605; ENSGGOP00000025809; ENSGGOG00000025559.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G3SCI1; -.
DR   OMA; RQKCPPW; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001519; Chromosome 2b.
DR   Bgee; ENSGGOG00000025559; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    739    765       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    777    795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    815    836       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    857    885       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    947    970       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1195   1213       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1234   1250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1311   1337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1396   1416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1436   1459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1548   1570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1582   1602       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      128    403       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      486    696       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      747    975       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      984   1189       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1193   1468       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1517   1613       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1614 AA;  184419 MW;  7C5468D180E1900A CRC64;
     MAMLPPPGPQ SFVHFTKQSL ALIEQRIAER KSKEPKEEKK DDDEEAPKPS SDLEAGKQLP
     FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKTIFRF NATPALYMLS PFSPLRRISI
     KILVHSSTLF SMLIMCTILT NCIFMTMNNP ADWTKNVEYT FTGIYTFESL VKILARGFCV
     GEFTFLRDPW NWLDFVVIVF AYLTEFVNLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLKHKCFRN SLENNETLES IMNTLESEED
     FRKYFYYLEG SKDALLCGFS TDSGQCPEGY TCMKIGRNPD YGYTSFDTFS WAFLALFRLM
     TQDYWENLYQ QKLFIRGKTY FSFNTHTQWI SSEYQLYTVV SWIVLGYPRY CLGNSQKFHS
     GHDYMHHVVT LIVLTSWPNQ AIAAAAAEYT SIRRSRIMGL SESSSETSKL SSKSAKERRN
     RRKKKNQKKL SSGEEKGDAE KLSKSESEDS IRRKSFHLGV EGHRRAHEKR LSTPNQSPLS
     IRGSLFSARR SSRTSLFSFK GRGRDIGSET EFADDEHSIF GDNESRRGSL FVPHRPQERR
     SSNISQASRS PPMLPVNGKM HSAVDCNGVV SLVDGRSALM LPNGQLLPEV IIDKATSDDS
     GTINQIHKKR RCSSYLLSED MLNDPNLRQR AMSRASILTN TVEELEESRQ KCPPWWYRFA
     HKFLIWNCSP YWIKFKKCIY FIVMDPFVDL AITICIVLNT LFMAMEHHPM TEEFKNVLAI
     GNLVFTGIFA AEMVLKLIAM DPYEYFQVGW NIFDSLIVTL SLVELFLADV EGLSVLRSFR
     LLRVFKLAKS WPTLNMLIKI IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKECVCK
     INDDCTLPRW HMNDFFHSFL IVFRVLCGEW IETMWDCMEV AGQAMCLIVY MMVMVIGNLV
     VLNLFLALLL SSFSSDNLTA IEEDPDANNL QIAVTRIKKG INYVKQTLRE FILKAFSKKP
     KISREIRQAE DLNTKKENYI SNHTLAEMSK GHNFLKEKDK ISGFGSSVDK HLMEDSDGQS
     FIHNPSLTVT VPIAPGESDL ENMNTEELSS DSDSEYSKVR LNRSSSSECS TVDNPLPGEG
     EEAEAEPMNS DEPEACFTDG CVRRFSCCQV NIESGKGKIW WNIRKTCYKI VEHSWFESFI
     VLMILLSSGA LAFEDIYIER KKTIKIILEY ADKIFTYIFI LEMLLKWIAY GYKTYFTNAW
     CWLDFLIVDV SLVTLVANTL GYSDLGPIKS LRTLRALRPL RALSRFEGMR VVVNALIGAI
     PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY ECINTTDGSR FPASQVPNRS ECFALMNVSQ
     NVRWKNLKVN FDNVGLGYLS LLQVATFKGW TIIMYAAVDS VNVDKQPKYE YSLYMYIYFV
     VFIIFGSFFT LNLFIGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP
     RPGNKIQGCI FDLVTNQAFD ISIMVLICLN MVTMMVEKEG QSQHMTEVLY WINVVFIILF
     TGECVLKLIS LRHYYFTVGW NIFDFVVVII SIVVVVIFTN LAKYFRIVFL FRII
//
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