ID G3SKS3_GORGO Unreviewed; 128 AA.
AC G3SKS3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=SH2 domain-containing protein 1A {ECO:0000256|ARBA:ARBA00013980, ECO:0000256|PIRNR:PIRNR037828};
GN Name=SH2D1A {ECO:0000313|Ensembl:ENSGGOP00000028716.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028716.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000028716.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000028716.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000028716.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cytoplasmic adapter regulating receptors of the signaling
CC lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244,
CC LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with
CC SH2D1B/EAT-2. {ECO:0000256|PIRNR:PIRNR037828}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR037828}.
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DR EMBL; CABD030128025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030128026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004064880.2; XM_004064832.2.
DR AlphaFoldDB; G3SKS3; -.
DR SMR; G3SKS3; -.
DR STRING; 9593.ENSGGOP00000028716; -.
DR Ensembl; ENSGGOT00000041064.2; ENSGGOP00000028716.1; ENSGGOG00000034950.2.
DR GeneID; 101136405; -.
DR KEGG; ggo:101136405; -.
DR CTD; 4068; -.
DR eggNOG; KOG0565; Eukaryota.
DR GeneTree; ENSGT00940000155920; -.
DR HOGENOM; CLU_125532_1_0_1; -.
DR InParanoid; G3SKS3; -.
DR OMA; CVLCNGY; -.
DR OrthoDB; 3891423at2759; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000001519; Chromosome X.
DR Bgee; ENSGGOG00000034950; Expressed in liver.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro.
DR GO; GO:0006968; P:cellular defense response; IEA:UniProtKB-UniRule.
DR GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR CDD; cd10400; SH2_SAP1a; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR017289; SH2_prot_1A.
DR InterPro; IPR035876; SH2D1A_SH2.
DR PANTHER; PTHR46051:SF1; IPPC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF037828; SH2_p1A; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130,
KW ECO:0000256|PIRNR:PIRNR037828}; Cytoplasm {ECO:0000256|PIRNR:PIRNR037828};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037828};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037828};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 6..102
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 106..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 128 AA; 14187 MW; 90234E7A6614EE3D CRC64;
MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE
TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED
PDVCLKAP
//
