ID   G3SLD3_LOXAF            Unreviewed;       686 AA.
AC   G3SLD3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=FCH and double SH3 domains 2 {ECO:0000313|Ensembl:ENSLAFP00000000214.3};
GN   Name=FCHSD2 {ECO:0000313|Ensembl:ENSLAFP00000000214.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000214.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000000214.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000214.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000000214.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000214.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3SLD3; -.
DR   Ensembl; ENSLAFT00000000260.3; ENSLAFP00000000214.3; ENSLAFG00000000261.3.
DR   GeneTree; ENSGT00510000046732; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   CDD; cd11894; SH3_FCHSD2_2; 1.
DR   CDD; cd11761; SH3_FCHSD_1; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR035556; FCHSD2_SH3_2.
DR   InterPro; IPR035460; FCHSD_SH3_1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15735:SF11; F-BAR AND DOUBLE SH3 DOMAINS PROTEIN 2; 1.
DR   PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..228
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          415..476
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          513..575
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          249..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..686
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          303..337
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        613..650
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  77853 MW;  842C92993D811B89 CRC64;
     QGIQKLASQY LKRDWPGVKA DDRNDYRSMY PVWKSFLEGT MQVAQSRISI CENYKNFISE
     PARTVRSLKE QQLKRCVDQL TKIQTELQET VKDLAKGKKK YFETEQMAHA VREKADIEAK
     SKLSLFQSRI SLQKASVKLK ARRSECNSKA THARNDYLLT LAAANAHQDR YYQTDLVNIM
     KALDGNVYDH LKDYLIAFSR TELETCQAVQ NTFQFLLETS SKVIRDYNLQ LFLQENAVFH
     KPQPFQFQPC DSDTSRQLES ETGTTEEHSL NKEARKWATR VAREHKNIVY QQRVLDELEC
     HGVAGSEQSR AELEQKIDEA RENIRKAEII KLKAEARLDL LKQIGVSVDT WLKSAMNQVM
     EELENERWAR LPAVTNNGTL HSLNADAEKE EGEEFEDNMD VFDDSSSSPS GTLRNYPLTC
     KVVYSYKASQ PDELTIEEHE VLEVIEDGDM EDWVKARNKV GQVGYVPEKY LQFPTSNSLL
     SMLQSLAALD SRSHTSSNST EAELVSGSLN GDASVCFVKA LYDYEGQTDD ELSFPEGAII
     RILNKENQAD DGFWEGEFSG RIGVFPSVLV EELSASENGD TPWIRDTQLP SLPKPHSSLP
     ALPLYDQPPS SPYLSPDKRS SQYFPRSPSA NENSFPSESP GFSQVPRHTP ETSYGKLRPV
     RAAPPPPTQN HRRPAEKIED VEITLV
//