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Database: UniProt
Entry: G3SLG2_LOXAF
LinkDB: G3SLG2_LOXAF
Original site: G3SLG2_LOXAF 
ID   G3SLG2_LOXAF            Unreviewed;      1512 AA.
AC   G3SLG2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00016709};
DE   AltName: Full=Cyclic nucleotide ras GEF {ECO:0000256|ARBA:ARBA00031545};
DE   AltName: Full=Neural RAP guanine nucleotide exchange protein {ECO:0000256|ARBA:ARBA00032021};
DE   AltName: Full=PDZ domain-containing guanine nucleotide exchange factor 1 {ECO:0000256|ARBA:ARBA00030673};
DE   AltName: Full=RA-GEF-1 {ECO:0000256|ARBA:ARBA00029925};
DE   AltName: Full=Ras/Rap1-associating GEF-1 {ECO:0000256|ARBA:ARBA00031980};
GN   Name=RAPGEF2 {ECO:0000313|Ensembl:ENSLAFP00000000251.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000251.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000000251.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000251.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000000251.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000251.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC       Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear
CC       region {ECO:0000256|ARBA:ARBA00004556}. Endosome
CC       {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC       {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC       {ECO:0000256|ARBA:ARBA00010829}.
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DR   STRING; 9785.ENSLAFP00000000251; -.
DR   Ensembl; ENSLAFT00000000302.3; ENSLAFP00000000251.3; ENSLAFG00000000302.3.
DR   eggNOG; KOG3542; Eukaryota.
DR   GeneTree; ENSGT00940000156418; -.
DR   HOGENOM; CLU_002782_0_1_1; -.
DR   InParanoid; G3SLG2; -.
DR   OMA; SSHMDQM; -.
DR   TreeFam; TF313184; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd01785; RA_PDZ-GEF1; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45161:SF2; CYCLIC NUCLEOTIDE RAS GEF; 1.
DR   PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          149..249
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          281..394
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          399..469
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          620..706
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          731..958
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          84..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1016..1061
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1106..1173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1232..1270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1318..1512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..110
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1038..1061
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1119..1173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1318..1349
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1352..1366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1512 AA;  168544 MW;  BA94C215AB7FB2D8 CRC64;
     LRGIFYLEKE AFSTQEMAFL VRCYANCLQP WSSKLPADFT KLHLADSLHP QVTHVSASHS
     GCSITSDSGS SSLSDIYQAT ESEAGDMDLS GLPETAVDSE DDDDEEDIER ASDPLMSRDI
     VRDCLEKDPI DRTDDDIEQL LEFMHQLPAF ANMTMSVRRE LCAVMVFAVV ERAGTIVLND
     GEELDSWSVI LNGSVEVTYP DGKAEILCMG NSFGVSPTMD KEYMKGVMKT KVDDCQFVCI
     AQQDYCRILN QVEKNMQKVE EEGEIVMVKE HRELDRTGTR KGHIVIKGTS ERLTMHLVEE
     HSVVDPTFIE DFLLTYRTFL SSPMEVGKKL LEWFNDPSLR DKVTRVVLLW VNNHFNDFEG
     DPAMTRFLEE FENNLEREKM GGHLRLLNIA CAAKAKRRLM TLTKPSREAP LPFLLLGGSE
     KGFGIFVDSV DSGSRATEAG LKRGDQILEV NGQNFENIQL SKAMEILRNN THLSITVKTN
     LFVFKELLTR LSEEKRNGAP HLPKIGDIKK ASRYSIPDLA VDVEQVIGLE KVNKKSKANT
     VGGRNKLKKI LDKTRISILP QKPYNDIGIG QSQDDSIVGL RQTKHIPTAL PVSGTLSSSN
     PDLLQSHHRI LDFSTTPDLP DQVLRVFKAD QQSRYIMISK DTTAKEVVVQ AIREFAVTTT
     PDQYSLCEVS VTPEGVIKQR RLPDQLSKLA DRIQLSGRYY LKNNMETETL CSDEDAQELL
     RESQISLLQL STVEVATQLS MRNFELFRNI EPTEYIDDLF KLKSKTSCAN LKTFEEVINQ
     ETFWVASEIL RETNQLKRMK IIKHFIKIAL HCRECKNFNS MFAIISGLNL APVARLRTTW
     EKLPNKYEKL FQDLQDLFDP SRNMAKYRNV LNSQNLQPPI IPLFPVIKKD LTFLHEGNDS
     KVDGLVNFEK LRMIAKEIRH VGRMASVNMD PALMFRTRKK KWRSLGSLSQ GSTNAAVLDV
     AQTGGHKKRV RRSSFLNAKK LYEDAQMARK VKQYLSNLEL EMDEDSLQTL SLQCEPATNT
     LPKNPGDKKP VKSETSPVAP RAGSQQKAQP QPPSQQQPLP HKISQGLQVP AVSLYPSRKK
     VPVKDLPPFG INSPQALKKI LSLSEEGSLE RHKKPAEDTV SNASSQLSSP PASPQSSPRK
     GCTLAPSGTV DNFSDSGHSE ISSRSSIVSN SSFDSVPVSL HDERHQRHSV SIVETSLGVG
     RLERRAVMEP DQYSLGSYAA VSESRGLYAT ATGISSPSTE ELSQDQGDRA SLDAADSGRG
     SWTSCSSGSH DNIQTIQHQR SWETLPFGHT HFDYSGDPPG LWASSSHMDQ IMFSDHSTKY
     NRQNQSRESL EQAQSRASWA SSTGYWGEDS EGDTGTIKRR GGKDVSVEAE SSSLAPVPTE
     EAKPAPVPAH IAAPSSTAKG LIARKEGRYR EPPPTPPGYI GIPITDFPEG HSHPARKPPD
     YTVALQRSRM VARSSEVPGP SPVQQPHGHP ASSRPVNKPQ WHKPNESDPR LAPYQSQGFS
     AEEDEDEQVS AV
//
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