ID G3SLG2_LOXAF Unreviewed; 1512 AA.
AC G3SLG2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=Rap guanine nucleotide exchange factor 2 {ECO:0000256|ARBA:ARBA00016709};
DE AltName: Full=Cyclic nucleotide ras GEF {ECO:0000256|ARBA:ARBA00031545};
DE AltName: Full=Neural RAP guanine nucleotide exchange protein {ECO:0000256|ARBA:ARBA00032021};
DE AltName: Full=PDZ domain-containing guanine nucleotide exchange factor 1 {ECO:0000256|ARBA:ARBA00030673};
DE AltName: Full=RA-GEF-1 {ECO:0000256|ARBA:ARBA00029925};
DE AltName: Full=Ras/Rap1-associating GEF-1 {ECO:0000256|ARBA:ARBA00031980};
GN Name=RAPGEF2 {ECO:0000313|Ensembl:ENSLAFP00000000251.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000251.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000251.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000251.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000251.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000251.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, perinuclear
CC region {ECO:0000256|ARBA:ARBA00004556}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Late endosome
CC {ECO:0000256|ARBA:ARBA00004603}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR STRING; 9785.ENSLAFP00000000251; -.
DR Ensembl; ENSLAFT00000000302.3; ENSLAFP00000000251.3; ENSLAFG00000000302.3.
DR eggNOG; KOG3542; Eukaryota.
DR GeneTree; ENSGT00940000156418; -.
DR HOGENOM; CLU_002782_0_1_1; -.
DR InParanoid; G3SLG2; -.
DR OMA; SSHMDQM; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45161:SF2; CYCLIC NUCLEOTIDE RAS GEF; 1.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 149..249
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 281..394
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 399..469
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 620..706
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 731..958
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 84..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1016..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1512 AA; 168544 MW; BA94C215AB7FB2D8 CRC64;
LRGIFYLEKE AFSTQEMAFL VRCYANCLQP WSSKLPADFT KLHLADSLHP QVTHVSASHS
GCSITSDSGS SSLSDIYQAT ESEAGDMDLS GLPETAVDSE DDDDEEDIER ASDPLMSRDI
VRDCLEKDPI DRTDDDIEQL LEFMHQLPAF ANMTMSVRRE LCAVMVFAVV ERAGTIVLND
GEELDSWSVI LNGSVEVTYP DGKAEILCMG NSFGVSPTMD KEYMKGVMKT KVDDCQFVCI
AQQDYCRILN QVEKNMQKVE EEGEIVMVKE HRELDRTGTR KGHIVIKGTS ERLTMHLVEE
HSVVDPTFIE DFLLTYRTFL SSPMEVGKKL LEWFNDPSLR DKVTRVVLLW VNNHFNDFEG
DPAMTRFLEE FENNLEREKM GGHLRLLNIA CAAKAKRRLM TLTKPSREAP LPFLLLGGSE
KGFGIFVDSV DSGSRATEAG LKRGDQILEV NGQNFENIQL SKAMEILRNN THLSITVKTN
LFVFKELLTR LSEEKRNGAP HLPKIGDIKK ASRYSIPDLA VDVEQVIGLE KVNKKSKANT
VGGRNKLKKI LDKTRISILP QKPYNDIGIG QSQDDSIVGL RQTKHIPTAL PVSGTLSSSN
PDLLQSHHRI LDFSTTPDLP DQVLRVFKAD QQSRYIMISK DTTAKEVVVQ AIREFAVTTT
PDQYSLCEVS VTPEGVIKQR RLPDQLSKLA DRIQLSGRYY LKNNMETETL CSDEDAQELL
RESQISLLQL STVEVATQLS MRNFELFRNI EPTEYIDDLF KLKSKTSCAN LKTFEEVINQ
ETFWVASEIL RETNQLKRMK IIKHFIKIAL HCRECKNFNS MFAIISGLNL APVARLRTTW
EKLPNKYEKL FQDLQDLFDP SRNMAKYRNV LNSQNLQPPI IPLFPVIKKD LTFLHEGNDS
KVDGLVNFEK LRMIAKEIRH VGRMASVNMD PALMFRTRKK KWRSLGSLSQ GSTNAAVLDV
AQTGGHKKRV RRSSFLNAKK LYEDAQMARK VKQYLSNLEL EMDEDSLQTL SLQCEPATNT
LPKNPGDKKP VKSETSPVAP RAGSQQKAQP QPPSQQQPLP HKISQGLQVP AVSLYPSRKK
VPVKDLPPFG INSPQALKKI LSLSEEGSLE RHKKPAEDTV SNASSQLSSP PASPQSSPRK
GCTLAPSGTV DNFSDSGHSE ISSRSSIVSN SSFDSVPVSL HDERHQRHSV SIVETSLGVG
RLERRAVMEP DQYSLGSYAA VSESRGLYAT ATGISSPSTE ELSQDQGDRA SLDAADSGRG
SWTSCSSGSH DNIQTIQHQR SWETLPFGHT HFDYSGDPPG LWASSSHMDQ IMFSDHSTKY
NRQNQSRESL EQAQSRASWA SSTGYWGEDS EGDTGTIKRR GGKDVSVEAE SSSLAPVPTE
EAKPAPVPAH IAAPSSTAKG LIARKEGRYR EPPPTPPGYI GIPITDFPEG HSHPARKPPD
YTVALQRSRM VARSSEVPGP SPVQQPHGHP ASSRPVNKPQ WHKPNESDPR LAPYQSQGFS
AEEDEDEQVS AV
//