ID G3SM13_LOXAF Unreviewed; 766 AA.
AC G3SM13;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=TBC1 domain family member 2 {ECO:0000313|Ensembl:ENSLAFP00000000503.3};
GN Name=TBC1D2 {ECO:0000313|Ensembl:ENSLAFP00000000503.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000503.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000503.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000503.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000503.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000503.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3SM13; -.
DR STRING; 9785.ENSLAFP00000000503; -.
DR Ensembl; ENSLAFT00000000598.3; ENSLAFP00000000503.3; ENSLAFG00000000598.3.
DR eggNOG; KOG2058; Eukaryota.
DR GeneTree; ENSGT00940000159937; -.
DR HOGENOM; CLU_011278_0_0_1; -.
DR InParanoid; G3SM13; -.
DR OMA; KTICNSR; -.
DR TreeFam; TF317336; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR CDD; cd01265; PH_TBC1D2A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR PANTHER; PTHR47219:SF16; TBC1 DOMAIN FAMILY MEMBER 2B; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 44..141
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 609..766
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 311..399
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 426..460
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..270
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 85919 MW; DBD735B2098A5669 CRC64;
MEGSQENTLE SGSSVPGPEE SARAPEVLPS EVSESCARPL ETTPKKLCGY LSKFGGKGPI
RGWKSRWFFY DERKCHLYYS RTAQDANPLD SIDLSSAVFD CKADAEEGTF EIKTPSRVIT
LKAATKQVML YWLQQLQMKR WEFHNSLPAP PAAPDAALAG NVPALRLKLE PEEAELEEFL
CPVKTPPGLV GMAAALQPGP PIPSALQNIS LKHLGTEIQN TMYNIRGNKQ AQGISQGPPG
EDSPQSRGPQ REEQPSPPDP STPGKEPADS PKPVPKSSLT ASLIQKAKRH NNTFPLFPEG
LTRNRTSQEK VVALEQQILM LTKDLKSQKE LVKILHKALE AAQQEKRASS AYLMAAGDED
RLELVRHKVR QIAELSSQVE ALEQERVSLA QTLVDKNQAK EQIICKLCEK VTQDFMNPPS
YSPVPLDAAD RDCLSQQEKM EQLKDDMEAY RTQNRFLNSE IHQVTKIWRK VAEKEKALLM
KCAYLQAKNC QVESKYLAGL RRLQEIMGDE ASKCSELLKQ LIQEALQWEA DEAVADGVRL
SPISEYDEYG FLTVPDYEVE DLKLLAKIQV LEVRSHHLLA HEEQPLRERW AALGELVPSA
ELKQLLRAGI PQEHRPRVWR WLVHLRVQHL QVPGHYQKLL SRGQTCEHPA ARQIELDLNR
TFPNNKHFTC PTSSFPDKLR RVLLAFSWQN PTIGYCQGLN RLAAIALLIL DEEESAFWCL
VAIVETILPA DYYSKTLTAS QHFRPPSSTL QLLPAPALPS PTILAG
//
