ID G3SMY2_LOXAF Unreviewed; 207 AA.
AC G3SMY2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Serotonin N-acetyltransferase {ECO:0000256|ARBA:ARBA00039398};
DE EC=2.3.1.87 {ECO:0000256|ARBA:ARBA00039114};
DE AltName: Full=Aralkylamine N-acetyltransferase {ECO:0000256|ARBA:ARBA00042928};
GN Name=AANAT {ECO:0000313|Ensembl:ENSLAFP00000000912.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000912.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000912.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000912.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000912.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000912.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Controls the night/day rhythm of melatonin production in the
CC pineal gland. Catalyzes the N-acetylation of serotonin into N-
CC acetylserotonin, the penultimate step in the synthesis of melatonin.
CC {ECO:0000256|ARBA:ARBA00037098}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine
CC + CoA + H(+); Xref=Rhea:RHEA:20497, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:55469, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:77827; EC=2.3.1.87;
CC Evidence={ECO:0000256|ARBA:ARBA00036561};
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000256|ARBA:ARBA00037926}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. AANAT subfamily.
CC {ECO:0000256|ARBA:ARBA00038182}.
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DR RefSeq; XP_010595231.1; XM_010596929.1.
DR AlphaFoldDB; G3SMY2; -.
DR STRING; 9785.ENSLAFP00000000912; -.
DR Ensembl; ENSLAFT00000001085.2; ENSLAFP00000000912.2; ENSLAFG00000001085.2.
DR GeneID; 100667906; -.
DR KEGG; lav:100667906; -.
DR CTD; 15; -.
DR eggNOG; KOG4144; Eukaryota.
DR GeneTree; ENSGT00390000015579; -.
DR HOGENOM; CLU_061829_3_1_1; -.
DR InParanoid; G3SMY2; -.
DR OMA; HFLNLCP; -.
DR OrthoDB; 1327238at2759; -.
DR TreeFam; TF331622; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0004059; F:aralkylamine N-acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0004060; F:arylamine N-acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR10908; SEROTONIN N-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10908:SF0; SEROTONIN N-ACETYLTRANSFERASE; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Melatonin biosynthesis {ECO:0000256|ARBA:ARBA00043260};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 35..196
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
SQ SEQUENCE 207 AA; 23466 MW; 00059464B22AB495 CRC64;
MSTQSVHALK LATLWLPPEV PDSPSRQRRH TLPASEFRCL SPEDATSVFE VEREAFISVS
GLCPLYLDEI RHFLIMCPEL SLGWFEEGRL VAFIIGSLWD EERLTQESLT LHRPGGRTAH
LHVLAVNHNF RQQGKGSVLL WRYLQHLGRQ PALCRVVLMC EDPLVPFYEK FGFRAVGPCA
VTVVSLAFIE LQCSLRGHAF LRRNSGC
//
