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Database: UniProt
Entry: G3SNI5_LOXAF
LinkDB: G3SNI5_LOXAF
Original site: G3SNI5_LOXAF 
ID   G3SNI5_LOXAF            Unreviewed;       440 AA.
AC   G3SNI5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=Myc proto-oncogene protein {ECO:0000256|ARBA:ARBA00013423, ECO:0000256|PIRNR:PIRNR001705};
GN   Name=MYC {ECO:0000313|Ensembl:ENSLAFP00000001181.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001181.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000001181.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001181.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000001181.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001181.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Transcription factor that binds DNA in a non-specific manner,
CC       yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.
CC       Activates the transcription of growth-related genes.
CC       {ECO:0000256|PIRNR:PIRNR001705}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000256|PIRNR:PIRNR001705}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
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DR   AlphaFoldDB; G3SNI5; -.
DR   STRING; 9785.ENSLAFP00000001181; -.
DR   Ensembl; ENSLAFT00000001411.3; ENSLAFP00000001181.3; ENSLAFG00000001410.3.
DR   eggNOG; KOG2483; Eukaryota.
DR   GeneTree; ENSGT00940000155285; -.
DR   HOGENOM; CLU_052560_0_0_1; -.
DR   InParanoid; G3SNI5; -.
DR   OMA; STRKDCP; -.
DR   TreeFam; TF106001; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0071943; C:Myc-Max complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0090571; C:RNA polymerase II transcription repressor complex; IEA:Ensembl.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0070888; F:E-box binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:1905761; F:SCF ubiquitin ligase complex binding; IEA:Ensembl.
DR   GO; GO:0001221; F:transcription coregulator binding; IEA:Ensembl.
DR   GO; GO:0140537; F:transcription regulator activator activity; IEA:Ensembl.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR   GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
DR   GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0006346; P:DNA methylation-dependent heterochromatin formation; IEA:Ensembl.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0051782; P:negative regulation of cell division; IEA:Ensembl.
DR   GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0045656; P:negative regulation of monocyte differentiation; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR   GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR   GO; GO:0032986; P:protein-DNA complex disassembly; IEA:Ensembl.
DR   GO; GO:0010564; P:regulation of cell cycle process; IEA:Ensembl.
DR   GO; GO:0032204; P:regulation of telomere maintenance; IEA:Ensembl.
DR   GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR   CDD; cd11458; bHLHzip_c-Myc; 1.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003327; Myc-LZ.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR   PANTHER; PTHR45851:SF1; MYC PROTO-ONCOGENE PROTEIN; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF02344; Myc-LZ; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR001705};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR001705};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          357..409
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   REGION          209..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          370..440
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        210..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..370
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  48641 MW;  3E983FCDCD830602 CRC64;
     QQAAAMPLNV SFANRNYDLD YDSVQPYFFD EEENFYQQQQ QSELQPPAPS EDIWKKFELL
     PTPPLSPSRR SGLCSPSYNL AFASFSPGGD DGGGGSFSTA DQLEMVTELL GGDMVNQSFI
     CDPDDENFIK NIIIQDCMWS GFSAAAKLVS EKLASYQAAR KDSGSPSPAR GHGGCSTSSL
     YLQDLSAAAS ECIDPSVVFP YPLNDGNSPK PCASPDSTAF SPSSDSLLSS AESSPLASPE
     PRALHEETPP TTSSDSEEEQ EDEEIDVVSV EKRQPPAKRS EAGSPPTGGH SKPPHSPLVL
     KRCHVSTHQH NYAAPPSTRK DYPATKRAKL DSGRVLKQIS NNRKCTSPRS SDTEENDKRR
     THNVLERQRR NELKRSFFAL RDQIPELENN EKAPKVVILK KATAYILSIQ AEEQKLISEK
     DLLRKRREQL KHKLEQLRNS
//
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