ID   G3SPB4_LOXAF            Unreviewed;       302 AA.
AC   G3SPB4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Hydroxysteroid 17-beta dehydrogenase 7 {ECO:0000313|Ensembl:ENSLAFP00000001526.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001526.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000001526.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001526.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000001526.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001526.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3SPB4; -.
DR   STRING; 9785.ENSLAFP00000001526; -.
DR   Ensembl; ENSLAFT00000001825.3; ENSLAFP00000001526.3; ENSLAFG00000001825.3.
DR   eggNOG; KOG1478; Eukaryota.
DR   GeneTree; ENSGT00390000013340; -.
DR   HOGENOM; CLU_029944_2_0_1; -.
DR   InParanoid; G3SPB4; -.
DR   OMA; HFMLIRE; -.
DR   TreeFam; TF105433; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR44442; 3-KETO-STEROID REDUCTASE; 1.
DR   PANTHER; PTHR44442:SF1; 3-KETO-STEROID REDUCTASE_17-BETA-HYDROXYSTEROID DEHYDROGENASE 7; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   302 AA;  34127 MW;  76E569A848410CF1 CRC64;
     MRKVVLVTGA DSGIGLAFCK RLLAEDDELH LCLACREMCK AEPVRDDLLA SHPTAEVTIV
     EVDVSNLRSV FRASKELKQR FQRLDYVYLN AGILLNPRLK IKELFSGLFS RKMIHMFSTA
     EGLLTQDDNI TADGLQEVFE TNVFGHFILV QELEPLLCHP DSPSQLIWTS SCSALRSNFS
     LEDFQHSKGQ EPYSSSKYAT DLLSVALNRN FNQRGLYSSV VCPGAVMTNL TYRILPPFIW
     MLLLPVILLL RFFVNSFTMT PYNGAEVLLW LFQQKPESLN PLIKYHSATT GLGNNYINPQ
     KV
//