ID G3SPF9_LOXAF Unreviewed; 432 AA.
AC G3SPF9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091};
GN Name=CNNM3 {ECO:0000313|Ensembl:ENSLAFP00000001585.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001585.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001585.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001585.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001585.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001585.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}.
CC -!- SIMILARITY: Belongs to the ACDP family.
CC {ECO:0000256|RuleBase:RU369091}.
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DR STRING; 9785.ENSLAFP00000001585; -.
DR Ensembl; ENSLAFT00000001895.2; ENSLAFP00000001585.2; ENSLAFG00000001896.2.
DR eggNOG; KOG2118; Eukaryota.
DR GeneTree; ENSGT00940000161102; -.
DR InParanoid; G3SPF9; -.
DR OMA; QPARHDL; -.
DR TreeFam; TF101012; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR045095; ACDP.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR PANTHER; PTHR12064:SF27; METAL TRANSPORTER CNNM3; 1.
DR Pfam; PF00571; CBS; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 112..178
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 325..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48568 MW; C926F4959F81E2E8 CRC64;
XLLELAARPG RLRERVLELA RGGGDPYSDL SKGVLRCRTV EDVLTPLEDC FMLDASAVLD
FGVLASIMQS GHTRIPVYEE ERSNIVDMLY LKDLAFVDPE DCTPLSTITR FYNHPLHFVF
NDTKLDAVLE EFKRGKSHLA IVQKVNNEGE GDPFYEVLGL VTLEDVIEEI IKSEILDESE
DYRDTKVRRK PASLSAPIRR KEEFSLFKVS DDEYKVKISP QLLLATQRFL SREVDVFSPR
ISEKVLLHLL KHPSVNQEVR FDASDRLAAD HYLYQRSQPV DYFILILQGR VEVEIGKEGL
KFENGAFTYY GVSALTAPSS VHQSPVSSLQ LSRRDPQPEP ADGTRSSTYC PDYTVRALSD
LQFIKVTRLQ YLNALLATRA QNMPQSPENE DLQVVPGSQT RLLSDRTAPA AGSHHSRPGL
PAEESPGRNP GV
//
